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- W1972802340 abstract "The unusual activity of some D-ring-seco estrogens led us to prepare several seco steroids related to dehydroepiandrosterone (DHEA) and to test for their ability to mimic thyroid hormone and 7-oxo-DHEA (1) as inducers of thermogenic enzymes in rats’ livers. Only one, 3β-acetoxy-17a-oxa-androst-5-ene-7,17-dione (17), was capable of inducing both mitochondrial glycerophosphate dehydrogenase and malic enzyme. The closely related 3β-hydroxy-17a-oxa-androsta-5,15-diene-7,17-diones (both 14α and 14β, 14 and 15) induce the formation of malic enzyme but not of glycerophosphate dehydrogenase. The 3β-propionyl ester of the above 14α steroid was not active, presumably because it was not deacylated in vivo. The 16,17 dicarboxylic acid (9) produced by opening the D-ring also induced the formation of malic enzyme but not of glycerophosphate dehydrogenase. 3β-Acetoxyandrost-5-ene-7,16,17-trione, an intermediate in the synthesis of D-ring seco compounds enhanced the formation of both enzymes. Twelve other D-ring seco compounds were not active. Seco androstanes oxygenated at position 7 and with expanded A or B rings were not active." @default.
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- W1972802340 date "1998-10-01" @default.
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- W1972802340 title "Ergosteroids III. syntheses and biological activity of seco-steroids related to dehydroepiandrosterone" @default.
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- W1972802340 doi "https://doi.org/10.1016/s0039-128x(98)00066-x" @default.
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