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• W1972804889 abstract "The platelet-derived growth factor (PDGF) system is crucial for blood vessel stability. In the present study, we evaluated whether PDGFs play a critical intraovarian survival role in gonadotropin-dependent folliculogenesis. We examined the effect of intrabursal administration of a selective platelet-derived growth factor receptor (PDGFR) inhibitor (AG1295) on follicular development, proliferation, apoptosis and blood vessel formation and stability in ovaries from rats treated with equine chorionic gonadotropin (eCG). The percentages of preantral follicles (PAFs) and early antral follicles (EAFs) were lower in AG1295-treated ovaries than in control ovaries (p < 0.01-0.05). The percentage of atretic follicles (AtrFs) increased in AG1295-treated ovaries compared to control (p < 0.05). The ovarian weight and estradiol concentrations were lower in AG1295-treated ovaries than in the control group (p < 0.01 and p < 0.05, respectively), whereas progesterone concentrations did not change. AG1295 decreased the proliferation index in EAFs (p < 0.05) and increased the percentage of nuclei positive for cleaved caspase-3 and apoptotic DNA fragmentation (p < 0.01-0.05). AG1295 increased the expression of Bax (p < 0.05) without changes in the expression of Bcl-2 protein. AG1295-treated ovaries increased the cleavage of caspase-8 (p < 0.05) and decreased AKT and BAD phosphorylation compared with control ovaries (p < 0.05). AG1295 caused a decrease not only in the endothelial cell area but also in the area of pericytes and vascular smooth muscle cells (VSMCs) in the ovary (p < 0.05). Our findings suggest that the local inhibition of PDGFs causes an increase in ovarian apoptosis through an imbalance in the ratio of antiapoptotic to proapoptotic proteins, thus leading a larger number of follicles to atresia. PDGFs could exert their mechanism of action through an autocrine/paracrine effect on granulosa and theca cells mediated by PDGFRs. In conclusion, these data clearly indicate that the PDGF system is necessary for follicular development induced by gonadotropins." @default.
• W1972804889 created "2016-06-24" @default.
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• W1972804889 date "2015-09-01" @default.
• W1972804889 modified "2023-10-05" @default.
• W1972804889 title "Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats" @default.
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• W1972804889 cites W1971411560 @default.
• W1972804889 cites W1973418567 @default.
• W1972804889 cites W1974308772 @default.
• W1972804889 cites W1975084628 @default.
• W1972804889 cites W1978288244 @default.
• W1972804889 cites W1988452851 @default.
• W1972804889 cites W1998090562 @default.
• W1972804889 cites W1999012962 @default.
• W1972804889 cites W2000250544 @default.
• W1972804889 cites W2004405131 @default.
• W1972804889 cites W2004462474 @default.
• W1972804889 cites W2005901552 @default.
• W1972804889 cites W2011323789 @default.
• W1972804889 cites W2013052118 @default.
• W1972804889 cites W2013986489 @default.
• W1972804889 cites W2023653988 @default.
• W1972804889 cites W2025128734 @default.
• W1972804889 cites W2033441741 @default.
• W1972804889 cites W2037624725 @default.
• W1972804889 cites W2044876775 @default.
• W1972804889 cites W2047930097 @default.
• W1972804889 cites W2058839845 @default.
• W1972804889 cites W2059454385 @default.
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• W1972804889 cites W2069129513 @default.
• W1972804889 cites W2070466664 @default.
• W1972804889 cites W2075578609 @default.
• W1972804889 cites W2076960363 @default.
• W1972804889 cites W2084072360 @default.
• W1972804889 cites W2085707821 @default.
• W1972804889 cites W2091803043 @default.
• W1972804889 cites W2092301750 @default.
• W1972804889 cites W2093096968 @default.
• W1972804889 cites W2097270150 @default.
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• W1972804889 cites W2106168906 @default.
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• W1972804889 cites W2121547206 @default.
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• W1972804889 cites W2133004016 @default.
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• W1972804889 cites W2135214297 @default.
• W1972804889 cites W2136331365 @default.
• W1972804889 cites W2137918853 @default.
• W1972804889 cites W2140998974 @default.
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• W1972804889 cites W2147114673 @default.
• W1972804889 cites W2149442576 @default.
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• W1972804889 doi "https://doi.org/10.1016/j.mce.2015.04.021" @default.
• W1972804889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25937181" @default.
• W1972804889 hasPublicationYear "2015" @default.
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