FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972807432> ?p ?o ?g. }

• W1972807432 endingPage "1186" @default.
• W1972807432 startingPage "1176" @default.
• W1972807432 abstract "The UvrA protein is the initial DNA damage-sensing protein in bacterial nucleotide excision repair and detects a wide variety of structurally unrelated lesions. After initial recognition of DNA damage, UvrA loads the UvrB protein onto the DNA. This protein then verifies the presence of a lesion, after which UvrA is released from the DNA. UvrA contains two ATPase domains, both belonging to the ABC ATPase superfamily. We have determined the activities of two mutants, in which a single domain was deactivated. Inactivation of either one ATPase domain in Escherichia coli UvrA results in a complete loss of ATPase activity, indicating that both domains function in a cooperative way. We could show that this ATPase activity is not required for the recognition of bulky lesions by UvrA, but it does promote the specific binding to the less distorting cyclobutane–pyrimidine dimer (CPD). The two ATPase mutants also show a difference in UvrB-loading, depending on the length of the DNA substrate. The ATPase domain I mutant was capable of loading UvrB on a lesion in a 50 bp fragment, but this loading was reduced on a longer substrate. For the ATPase domain II mutant the opposite was found: UvrB could not be loaded on a 50 bp substrate, but this loading was rescued when the length of the fragment was increased. This differential loading of UvrB by the two ATPase mutants could be related to different interactions between the UvrA and UvrB subunits." @default.
• W1972807432 created "2016-06-24" @default.
• W1972807432 creator A5011799227 @default.
• W1972807432 creator A5037692009 @default.
• W1972807432 creator A5069611848 @default.
• W1972807432 date "2010-11-01" @default.
• W1972807432 modified "2023-10-16" @default.
• W1972807432 title "Role of the two ATPase domains of Escherichia coli UvrA in binding non-bulky DNA lesions and interaction with UvrB" @default.
• W1972807432 cites W1518834999 @default.
• W1972807432 cites W1539476045 @default.
• W1972807432 cites W1540859569 @default.
• W1972807432 cites W1565070829 @default.
• W1972807432 cites W1657073639 @default.
• W1972807432 cites W1967105053 @default.
• W1972807432 cites W1968360469 @default.
• W1972807432 cites W1971793867 @default.
• W1972807432 cites W1976744814 @default.
• W1972807432 cites W1988508963 @default.
• W1972807432 cites W1991391441 @default.
• W1972807432 cites W2009091406 @default.
• W1972807432 cites W2020084384 @default.
• W1972807432 cites W2025790565 @default.
• W1972807432 cites W2027455713 @default.
• W1972807432 cites W2028326921 @default.
• W1972807432 cites W2045213554 @default.
• W1972807432 cites W2047688181 @default.
• W1972807432 cites W2055634974 @default.
• W1972807432 cites W2058690915 @default.
• W1972807432 cites W2060529952 @default.
• W1972807432 cites W2060583705 @default.
• W1972807432 cites W2082450857 @default.
• W1972807432 cites W2087742264 @default.
• W1972807432 cites W2089341557 @default.
• W1972807432 cites W2095350558 @default.
• W1972807432 cites W2096338604 @default.
• W1972807432 cites W2098599440 @default.
• W1972807432 cites W2103076122 @default.
• W1972807432 cites W2116573367 @default.
• W1972807432 cites W2127256267 @default.
• W1972807432 cites W2141989201 @default.
• W1972807432 cites W2144481268 @default.
• W1972807432 cites W2159453189 @default.
• W1972807432 cites W2162444849 @default.
• W1972807432 cites W2163888020 @default.
• W1972807432 cites W2172282157 @default.
• W1972807432 doi "https://doi.org/10.1016/j.dnarep.2010.08.008" @default.
• W1972807432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20864419" @default.
• W1972807432 hasPublicationYear "2010" @default.
• W1972807432 type Work @default.
• W1972807432 sameAs 1972807432 @default.
• W1972807432 citedByCount "20" @default.
• W1972807432 countsByYear W19728074322012 @default.
• W1972807432 countsByYear W19728074322013 @default.
• W1972807432 countsByYear W19728074322015 @default.
• W1972807432 countsByYear W19728074322016 @default.
• W1972807432 countsByYear W19728074322017 @default.
• W1972807432 countsByYear W19728074322018 @default.
• W1972807432 countsByYear W19728074322019 @default.
• W1972807432 countsByYear W19728074322020 @default.
• W1972807432 countsByYear W19728074322021 @default.
• W1972807432 crossrefType "journal-article" @default.
• W1972807432 hasAuthorship W1972807432A5011799227 @default.
• W1972807432 hasAuthorship W1972807432A5037692009 @default.
• W1972807432 hasAuthorship W1972807432A5069611848 @default.
• W1972807432 hasConcept C104317684 @default.
• W1972807432 hasConcept C104451858 @default.
• W1972807432 hasConcept C134935766 @default.
• W1972807432 hasConcept C143065580 @default.
• W1972807432 hasConcept C143425029 @default.
• W1972807432 hasConcept C153911025 @default.
• W1972807432 hasConcept C167975912 @default.
• W1972807432 hasConcept C181199279 @default.
• W1972807432 hasConcept C23265538 @default.
• W1972807432 hasConcept C547475151 @default.
• W1972807432 hasConcept C552990157 @default.
• W1972807432 hasConcept C55493867 @default.
• W1972807432 hasConcept C86803240 @default.
• W1972807432 hasConceptScore W1972807432C104317684 @default.
• W1972807432 hasConceptScore W1972807432C104451858 @default.
• W1972807432 hasConceptScore W1972807432C134935766 @default.
• W1972807432 hasConceptScore W1972807432C143065580 @default.
• W1972807432 hasConceptScore W1972807432C143425029 @default.
• W1972807432 hasConceptScore W1972807432C153911025 @default.
• W1972807432 hasConceptScore W1972807432C167975912 @default.
• W1972807432 hasConceptScore W1972807432C181199279 @default.
• W1972807432 hasConceptScore W1972807432C23265538 @default.
• W1972807432 hasConceptScore W1972807432C547475151 @default.
• W1972807432 hasConceptScore W1972807432C552990157 @default.
• W1972807432 hasConceptScore W1972807432C55493867 @default.
• W1972807432 hasConceptScore W1972807432C86803240 @default.
• W1972807432 hasIssue "11" @default.
• W1972807432 hasLocation W19728074321 @default.
• W1972807432 hasLocation W19728074322 @default.
• W1972807432 hasOpenAccess W1972807432 @default.
• W1972807432 hasPrimaryLocation W19728074321 @default.
• W1972807432 hasRelatedWork W1501527150 @default.
• W1972807432 hasRelatedWork W2043958353 @default.
• W1972807432 hasRelatedWork W2102411358 @default.

• next