FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972809568> ?p ?o ?g. }

• W1972809568 endingPage "90" @default.
• W1972809568 startingPage "80" @default.
• W1972809568 abstract "Ewing sarcoma is a paradigm of solid tumour -bearing chromosomal translocations resulting in fusion proteins that act as deregulated transcription factors. Ewing sarcoma translocations fuse the EWS gene with an ETS transcription factor, mainly FLI1. Most of the EWS-FLI1 target genes still remain unknown and many have been identified in heterologous model systems.We have developed a stable RNA interference model knocking down EWS-FLI1 in the Ewing sarcoma cell line TC71. Gene expression analyses were performed to study the effect of RNA interference on the genetic signature of EWS-FLI1 and to identify genes that could contribute to tumourigenesis.EWS-FLI1 inhibition induced apoptosis, reduced cell migratory and tumourigenic capacities, and caused reduction in tumour growth. IGF-1 was downregulated and the IGF-1/IGF-1R signalling pathway was impaired. PBK/TOPK (T-LAK cell-originated protein kinase) expression was decreased because of EWS-FLI1 inhibition. We showed that TOPK is a new target gene of EWS-FLI1. TOPK inhibition prompted a decrease in the proliferation rate and a dramatic change in the cell's ability to grow in coalescence.This is the first report of TOPK activity in Ewing sarcoma and suggests a significant role of this MAPKK-like protein kinase in the Ewing sarcoma biology." @default.
• W1972809568 created "2016-06-24" @default.
• W1972809568 creator A5006108242 @default.
• W1972809568 creator A5012392244 @default.
• W1972809568 creator A5013489598 @default.
• W1972809568 creator A5013783918 @default.
• W1972809568 creator A5022969007 @default.
• W1972809568 creator A5027922544 @default.
• W1972809568 creator A5036256739 @default.
• W1972809568 creator A5037401124 @default.
• W1972809568 creator A5044250695 @default.
• W1972809568 creator A5052609273 @default.
• W1972809568 creator A5054566975 @default.
• W1972809568 creator A5077480042 @default.
• W1972809568 creator A5081841674 @default.
• W1972809568 creator A5082280101 @default.
• W1972809568 creator A5084687566 @default.
• W1972809568 creator A5085470464 @default.
• W1972809568 creator A5087611420 @default.
• W1972809568 date "2009-06-02" @default.
• W1972809568 modified "2023-10-07" @default.
• W1972809568 title "Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target" @default.
• W1972809568 cites W1981301410 @default.
• W1972809568 cites W1981906930 @default.
• W1972809568 cites W1986834606 @default.
• W1972809568 cites W1997220932 @default.
• W1972809568 cites W1999030960 @default.
• W1972809568 cites W2000646653 @default.
• W1972809568 cites W2009715632 @default.
• W1972809568 cites W2016721805 @default.
• W1972809568 cites W2023788598 @default.
• W1972809568 cites W2024423624 @default.
• W1972809568 cites W2034176492 @default.
• W1972809568 cites W2038783205 @default.
• W1972809568 cites W2049726073 @default.
• W1972809568 cites W2052387289 @default.
• W1972809568 cites W2055854406 @default.
• W1972809568 cites W2058759427 @default.
• W1972809568 cites W2069351898 @default.
• W1972809568 cites W2080563239 @default.
• W1972809568 cites W2087253247 @default.
• W1972809568 cites W2090915824 @default.
• W1972809568 cites W2093510891 @default.
• W1972809568 cites W2094805285 @default.
• W1972809568 cites W2096113686 @default.
• W1972809568 cites W2102802740 @default.
• W1972809568 cites W2103126498 @default.
• W1972809568 cites W2109456873 @default.
• W1972809568 cites W2115967766 @default.
• W1972809568 cites W2123248195 @default.
• W1972809568 cites W2123411826 @default.
• W1972809568 cites W2123477904 @default.
• W1972809568 cites W2135976466 @default.
• W1972809568 cites W2146431497 @default.
• W1972809568 cites W2151444534 @default.
• W1972809568 cites W2151526351 @default.
• W1972809568 cites W2161444433 @default.
• W1972809568 cites W2170407716 @default.
• W1972809568 cites W2324307412 @default.
• W1972809568 cites W2325098089 @default.
• W1972809568 cites W2419123429 @default.
• W1972809568 cites W4248440390 @default.
• W1972809568 doi "https://doi.org/10.1038/sj.bjc.6605104" @default.
• W1972809568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2694277" @default.
• W1972809568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19491900" @default.
• W1972809568 hasPublicationYear "2009" @default.
• W1972809568 type Work @default.
• W1972809568 sameAs 1972809568 @default.
• W1972809568 citedByCount "98" @default.
• W1972809568 countsByYear W19728095682012 @default.
• W1972809568 countsByYear W19728095682013 @default.
• W1972809568 countsByYear W19728095682014 @default.
• W1972809568 countsByYear W19728095682015 @default.
• W1972809568 countsByYear W19728095682016 @default.
• W1972809568 countsByYear W19728095682017 @default.
• W1972809568 countsByYear W19728095682018 @default.
• W1972809568 countsByYear W19728095682019 @default.
• W1972809568 countsByYear W19728095682020 @default.
• W1972809568 countsByYear W19728095682021 @default.
• W1972809568 countsByYear W19728095682022 @default.
• W1972809568 countsByYear W19728095682023 @default.
• W1972809568 crossrefType "journal-article" @default.
• W1972809568 hasAuthorship W1972809568A5006108242 @default.
• W1972809568 hasAuthorship W1972809568A5012392244 @default.
• W1972809568 hasAuthorship W1972809568A5013489598 @default.
• W1972809568 hasAuthorship W1972809568A5013783918 @default.
• W1972809568 hasAuthorship W1972809568A5022969007 @default.
• W1972809568 hasAuthorship W1972809568A5027922544 @default.
• W1972809568 hasAuthorship W1972809568A5036256739 @default.
• W1972809568 hasAuthorship W1972809568A5037401124 @default.
• W1972809568 hasAuthorship W1972809568A5044250695 @default.
• W1972809568 hasAuthorship W1972809568A5052609273 @default.
• W1972809568 hasAuthorship W1972809568A5054566975 @default.
• W1972809568 hasAuthorship W1972809568A5077480042 @default.
• W1972809568 hasAuthorship W1972809568A5081841674 @default.
• W1972809568 hasAuthorship W1972809568A5082280101 @default.
• W1972809568 hasAuthorship W1972809568A5084687566 @default.
• W1972809568 hasAuthorship W1972809568A5085470464 @default.

• next