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- W1972830524 abstract "Article1 July 1961Studies of the Pathogenesis of Human HypertensionThe Adrenal Cortex and Renal Pressor MechanismJACQUES GENEST, M.D., F.R.C.P., (C)F.A.C.P., P. BIRON, M.D., E. KOIW, PHYS. ENG., W. NOWACZYNSKI, D.SC., R. BOUCHER, PH.D., M. CHRÉTIEN, M.D.JACQUES GENEST, M.D., F.R.C.P., (C)F.A.C.P.Search for more papers by this author, P. BIRON, M.D.Search for more papers by this author, E. KOIW, PHYS. ENG.Search for more papers by this author, W. NOWACZYNSKI, D.SC.Search for more papers by this author, R. BOUCHER, PH.D.Search for more papers by this author, M. CHRÉTIEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-12 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the meeting of The American College of Physicians in Los Angeles in 1956 we reported our preliminary findings of a significantly greater urinary aldosterone excretion in patients with severe essential and malignant hypertension than in normal subjects. This study was based on a biological determination of a purified aldosterone fraction obtained after two successive chromatographic purifications of the crude, neutral extract of acidified urine (1). These studies of the relationship of adrenocortical hormones to hypertensive disease have been continued and, by using a more specific physicochemical method for the isolation and determination of urinary aldosterone, have been extended to...References1. GENESTLEMIEUXDAVIGNONKOIWNOWACZYNSKISTEYERMARK JGAEWP: Human arterial hypertension: a state of mild, chronic hyperaldosteronism? Science 123: 503, 1956. CrossrefMedlineGoogle Scholar2. GENESTKOIWNOWACZYNSKILEBOEUF JEWG: Further studies on urinary aldosterone in human arterial hypertension. Proc. Soc. Exp. Biol. Med. 97: 676, 1958. CrossrefMedlineGoogle Scholar3. GENESTKOIWNOWACZYNSKISANDOR JEWT: Study of a large urinary steroid spectrum in normal subjects and hypertensive patients. Acta Endocr. 35: 413, 1960. CrossrefMedlineGoogle Scholar4. GENESTKOIWBEAUREGARDNOWACZYNSKISANDORBROUILLETBOLTEVERDYMARC-AURÈLE JEPWTJEMJ: Electrolytes and corticosteroids study in a 15-year-old girl with primary aldosteronism and malignant hypertension. Metabolism 9: 624, 1960. MedlineGoogle Scholar5. NOWACZYNSKIKOIWGENEST WEJ: Chemical method for the determination of urinary aldosterone. Canad. J. Biochem. 35: 425, 1957. MedlineGoogle Scholar6. BONGIOVANNIEBERLEIN AMWR: Critical analysis of methods for measurements of pregnane-3α,17α,21α-triol in human urine. Anal. Chem. 30: 388, 1958. CrossrefGoogle Scholar7. NOWACZYNSKIKOIWGENEST WEJ: Method for determination of urinary 5β-pregnane-3α,17α,20α-triol and Δ5-pregnane-3β,17α,20α-triol. J. Clin. Endocr. 20: 1503, 1960. CrossrefGoogle Scholar8. VENNINGDYRENFURTHDOSSITORBECK EHIJBJC: Essential hypertension and aldosterone. Crculation 23: 168, 1961. CrossrefMedlineGoogle Scholar9. TRONCHETTIROMANELLI FR: Aldosterone e sindromi ipertensive. Folia Endocr. To be published. Google Scholar10. TRONCHETTIMUINOROMANELLI FGR: Aldosterone et maladies vasculaires hypertensives. Ann. Endocr. 18: 654, 1957. Google Scholar11. ROMANELLIBIANCALANAMAPERAZZI RDE: Relationship between aldosterone and primary hypertension. Presented at First International Congress of Endocrinology, Copenhagen, 1960. Google Scholar12. ROMANELLI R: Personal communication. Google Scholar13. 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TOBIAN L: Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiol. Rev. 40: 280, 1960. CrossrefMedlineGoogle Scholar20. ELLIOTTPEART DFWS: Amino-acid sequence in a hypertension. Nature 177: 527, 1956. CrossrefMedlineGoogle Scholar21. BOCKKRECKE KDHJ: Die wirkung von synthetischem hypertensin II auf die PAH-und inulin-clearance, die renale hamodynamik und die diurise bum menschen. Klin. Wschr. 36: pp. 69, 254, 808, 1958. CrossrefMedlineGoogle Scholar22. PEART WS: Hypertension and the kidney. II. Experimental basis of renal hypertension. Brit. Med. J. 1: 1421, 1959. CrossrefGoogle Scholar23. PEART WS: Possible relationship between salt metabolism and the angiotensin system, in Essential Hypertension: An International Symposium, Springer-Verlag, Heidelberg, 1960, p. 112. CrossrefGoogle Scholar24. PEARTBROWN WSJJ: Effect of angiotensin (hypertension or angiotonin) on urine flow and electrolyte excretion in hypertensive patients. Lancet 1: 28, 1961. CrossrefMedlineGoogle Scholar25. BIRONKOIWNOWACZYNSKIBROUILLETGENEST PEWJJ:The effects of intravenous infusions of valine-5-angiotensin II and other pressor agents on urinary electrolytes and corticosteriods including aldosterone. J. Clin. Invest. 40: 338, 1961. CrossrefMedlineGoogle Scholar26. GENEST J: Angiotensin, aldosterone and human arterial hypertension. Canad. Med. Ass. J. 84: 403, 1961. MedlineGoogle Scholar27. BROUILLETGENEST JJ: Effect of epinephrine and norepinephrine infusions on urinary aldosterone and 17-hydroxycorticosteroids. Proc. Canad. Fed. Biol. Soc., First Annual Meeting, Kingston, June, 1958. Google Scholar28. LIDDLEISLANDLANCEHARRIS GWDEMAP: Alterations of adrenal steroid patterns in man resulting from treatment with a chemical inhibitor of 11-β-hydroxylation. J. Clin. Endocr. 18: 906, 1958. CrossrefMedlineGoogle Scholar29. BOUCHERBIRONGENEST RPJ: Procedure for isolation and determination of human blood angiotensin. Canad. J. Biochem. 39: 581, 1961. Google Scholar30. BIRONCHRÉTIENBOUCHERGENEST PMRJ: Blood angiotensin in normal subjects and hypertensive patients. To be published. Google Scholar31. LARAGHULICKJANUSZEWICZDEMINGKELLYLIEBERMAN JSVQBWGS: Aldosterone secretion and primary and malignant hypertension. J. Clin. Invest. 39: 1091, 1960. CrossrefMedlineGoogle Scholar32. LARAGH JH: Aldosteronism and arterial hypertension. Med. Clin. N. Amer. 45: 321, 1961. CrossrefMedlineGoogle Scholar33. GENESTNOWACZYNSKIKOIWSANDOR JWET: Study of a large spectrum of adrenocortical hormones in urines of normal subjects and hypertensive patients. Circulation 20: 700, 1959. (Abstr.) Google Scholar34. TOBIAN L: Physiology of the juxtaglomerular cells. Ann. Intern. Med. 52: 395, 1960. LinkGoogle Scholar35. GENESTNOWACZYNSKIKOIWSANDORBIRON JWETP: Adrenocortical function in essential hypertension, in Essential Hypertention: An International Symposium, Springer-Verlag, Heidelberg, 1960, p. 126. CrossrefGoogle Scholar36. LARAGHANGERSKELLYLIEBERMAN JHMWGS: Hypotensive agents and pressor substances. J. A. M. A. 174: 234, 1960. CrossrefMedlineGoogle Scholar37. COTTIER P: Renale hadmodynamicks, wasser und elektrolytausscheidung bei hypertone. Helv. Med. Acta, Suppl. 39, 1960. Google Scholar38. DEANEMASSON HWGM: Adrenal cortical changes in rats with various types of experimental hypertension. J. Clin. Endocr. 11: 193, 1951. CrossrefGoogle Scholar39. HARTROFTNEWMARKPITCOCK PMLNJA: Relationship of renal juxtaglomerular cells to sodium chloride, adrenal cortex and hypertension, in Hypertension: The First Hahnemann Symposium on Hypertensive Disease, ed. by Moyer, J. H., W. B. Saunders Company, Philadelphia, 1959, p. 29. Google Scholar40. GROSS F: Adrenocortical function and renal pressor mechanisms in experimental hypertension, in Essential Hypertension: An International Symposium, Springer-Verlag, Heidelberg, 1960, p. 92. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montréal,Received for publication April 24, 1961.From the Clinical Research Department, Hôtel-Dieu de Montréal, 3840 Rue St-Urbain, Montréal 18, Canada.Presented at the Forty-second Annual Session of The American College of Physicians, May 8-12, 1961, Bal Harbour, Fla.This work was supported by grants of the Ministries of Health (Federal-Provincial Plan), the Medical Research Council of Canada, the Life Insurance Medical Research Fund of New York, and the Ciba Pharmaceutical Co., Montréal.Dr. Chrétien is a Research Fellow of the Medical Research Council, Ottawa, Canada.Requests for reprints should be addressed to Jacques Genest, M.D., Director, Clinical Research Dept., Hôtel-Dieu de Montréal, 3840 Rue St-Urbain, Montréal 18, Can. 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Many causes?Myocardial Actions of AngiotensinOn the integration of factors in essential hypertensionAntihypertensive AgentsThe epidemiology of essential hypertensionUntersuchungen �ber die Serum-AngiotensinaseHypertonie und AldosteronALDOSTERONE AND THE CIRCULATIONA Longitudinal Study of Blood PressureRenal and Adrenal Relationships in Refractory EdemaEFFECTS OF ANGIOTENSIN INFUSIONS ON URINARY EXCRETION OF COMPOUND III AND SUBSTANCES OTHER THAN ALDOSTERONETinea PedisNEW THOUGHTS ON HYPERTENSIONRENAL TUBULAR ACTIVITIESEFFECTS OF ANGIOTENSIN INFUSIONS ON URINARY EXCRETION OF COMPOUND III AND SUBSTANCES OTHER THAN ALDOSTERONE 1 July 1961Volume 55, Issue 1Page: 12-28KeywordsAldosteroneExcretionGratitudeHealth insuranceHormonesHypertensionPathogenesisResearch fundingUrine Issue Published: 1 July 1961 PDF downloadLoading ..." @default.
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