Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972836161> ?p ?o ?g. }
- W1972836161 endingPage "209" @default.
- W1972836161 startingPage "204" @default.
- W1972836161 abstract "Background A major outbreak of methicillin-resistant Staphylococcus aureus (MRSA) occurred in locations C and Z of our hospital and lasted for several years. It affected 1,230 patients and 153 personnel. Methods Outbreak management was installed according to the Dutch “search and destroy” policy. A rapid, high-throughput method for molecular screening of potential MRSA carriers was implemented. Outbreak isolates were retrospectively genotyped by pulsed field gel electrophoresis. Costs of molecular screening were compared with screening by culture. Results Genotyping results revealed 4 distinct epidemic MRSA clones. Three were present in hospital C. Because of a merger of hospitals, these clones spread to hospital Z. Another clone of MRSA affected other health care-related institutions in the region. Because of the implementation of strict containment measures of the “search and destroy” policy, the annual number of tests decreased from 100,000 to 18,000. The disposables and reagents used in polymerase chain reaction technology are more expensive than those of conventional methods. However, the clinical and economic benefits of fast results in regard to expenses of the hospital clearly outweigh the higher costs of screening. Conclusion The implementation of a rapid, high-throughput molecular screening system greatly contributed to the effectiveness of strict containment measures of the “search and destroy” policy. The major epidemic clones of MRSA in the outbreak were eradicated by this strategy. A major outbreak of methicillin-resistant Staphylococcus aureus (MRSA) occurred in locations C and Z of our hospital and lasted for several years. It affected 1,230 patients and 153 personnel. Outbreak management was installed according to the Dutch “search and destroy” policy. A rapid, high-throughput method for molecular screening of potential MRSA carriers was implemented. Outbreak isolates were retrospectively genotyped by pulsed field gel electrophoresis. Costs of molecular screening were compared with screening by culture. Genotyping results revealed 4 distinct epidemic MRSA clones. Three were present in hospital C. Because of a merger of hospitals, these clones spread to hospital Z. Another clone of MRSA affected other health care-related institutions in the region. Because of the implementation of strict containment measures of the “search and destroy” policy, the annual number of tests decreased from 100,000 to 18,000. The disposables and reagents used in polymerase chain reaction technology are more expensive than those of conventional methods. However, the clinical and economic benefits of fast results in regard to expenses of the hospital clearly outweigh the higher costs of screening. The implementation of a rapid, high-throughput molecular screening system greatly contributed to the effectiveness of strict containment measures of the “search and destroy” policy. The major epidemic clones of MRSA in the outbreak were eradicated by this strategy." @default.
- W1972836161 created "2016-06-24" @default.
- W1972836161 creator A5030463138 @default.
- W1972836161 creator A5032847435 @default.
- W1972836161 creator A5058072405 @default.
- W1972836161 creator A5067154221 @default.
- W1972836161 creator A5074940176 @default.
- W1972836161 date "2013-03-01" @default.
- W1972836161 modified "2023-09-25" @default.
- W1972836161 title "Review of a major epidemic of methicillin-resistant Staphylococcus aureus: The costs of screening and consequences of outbreak management" @default.
- W1972836161 cites W1899245726 @default.
- W1972836161 cites W1903874587 @default.
- W1972836161 cites W1964800392 @default.
- W1972836161 cites W2003680189 @default.
- W1972836161 cites W2005863651 @default.
- W1972836161 cites W2036708411 @default.
- W1972836161 cites W2083093742 @default.
- W1972836161 cites W2133972351 @default.
- W1972836161 cites W2138460783 @default.
- W1972836161 cites W2149884477 @default.
- W1972836161 cites W2154541930 @default.
- W1972836161 cites W2154820398 @default.
- W1972836161 cites W2159308620 @default.
- W1972836161 cites W2161593000 @default.
- W1972836161 cites W2165707097 @default.
- W1972836161 cites W2077851982 @default.
- W1972836161 doi "https://doi.org/10.1016/j.ajic.2012.02.033" @default.
- W1972836161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22921104" @default.
- W1972836161 hasPublicationYear "2013" @default.
- W1972836161 type Work @default.
- W1972836161 sameAs 1972836161 @default.
- W1972836161 citedByCount "23" @default.
- W1972836161 countsByYear W19728361612013 @default.
- W1972836161 countsByYear W19728361612014 @default.
- W1972836161 countsByYear W19728361612015 @default.
- W1972836161 countsByYear W19728361612016 @default.
- W1972836161 countsByYear W19728361612017 @default.
- W1972836161 countsByYear W19728361612018 @default.
- W1972836161 countsByYear W19728361612019 @default.
- W1972836161 countsByYear W19728361612020 @default.
- W1972836161 countsByYear W19728361612021 @default.
- W1972836161 countsByYear W19728361612023 @default.
- W1972836161 crossrefType "journal-article" @default.
- W1972836161 hasAuthorship W1972836161A5030463138 @default.
- W1972836161 hasAuthorship W1972836161A5032847435 @default.
- W1972836161 hasAuthorship W1972836161A5058072405 @default.
- W1972836161 hasAuthorship W1972836161A5067154221 @default.
- W1972836161 hasAuthorship W1972836161A5074940176 @default.
- W1972836161 hasBestOaLocation W19728361612 @default.
- W1972836161 hasConcept C104317684 @default.
- W1972836161 hasConcept C116675565 @default.
- W1972836161 hasConcept C135763542 @default.
- W1972836161 hasConcept C159047783 @default.
- W1972836161 hasConcept C166888038 @default.
- W1972836161 hasConcept C177713679 @default.
- W1972836161 hasConcept C194828623 @default.
- W1972836161 hasConcept C2775941552 @default.
- W1972836161 hasConcept C2777052132 @default.
- W1972836161 hasConcept C2779489039 @default.
- W1972836161 hasConcept C31467283 @default.
- W1972836161 hasConcept C523546767 @default.
- W1972836161 hasConcept C54355233 @default.
- W1972836161 hasConcept C55493867 @default.
- W1972836161 hasConcept C71924100 @default.
- W1972836161 hasConcept C86803240 @default.
- W1972836161 hasConcept C89423630 @default.
- W1972836161 hasConceptScore W1972836161C104317684 @default.
- W1972836161 hasConceptScore W1972836161C116675565 @default.
- W1972836161 hasConceptScore W1972836161C135763542 @default.
- W1972836161 hasConceptScore W1972836161C159047783 @default.
- W1972836161 hasConceptScore W1972836161C166888038 @default.
- W1972836161 hasConceptScore W1972836161C177713679 @default.
- W1972836161 hasConceptScore W1972836161C194828623 @default.
- W1972836161 hasConceptScore W1972836161C2775941552 @default.
- W1972836161 hasConceptScore W1972836161C2777052132 @default.
- W1972836161 hasConceptScore W1972836161C2779489039 @default.
- W1972836161 hasConceptScore W1972836161C31467283 @default.
- W1972836161 hasConceptScore W1972836161C523546767 @default.
- W1972836161 hasConceptScore W1972836161C54355233 @default.
- W1972836161 hasConceptScore W1972836161C55493867 @default.
- W1972836161 hasConceptScore W1972836161C71924100 @default.
- W1972836161 hasConceptScore W1972836161C86803240 @default.
- W1972836161 hasConceptScore W1972836161C89423630 @default.
- W1972836161 hasIssue "3" @default.
- W1972836161 hasLocation W19728361611 @default.
- W1972836161 hasLocation W19728361612 @default.
- W1972836161 hasLocation W19728361613 @default.
- W1972836161 hasLocation W19728361614 @default.
- W1972836161 hasOpenAccess W1972836161 @default.
- W1972836161 hasPrimaryLocation W19728361611 @default.
- W1972836161 hasRelatedWork W2034790723 @default.
- W1972836161 hasRelatedWork W2074470152 @default.
- W1972836161 hasRelatedWork W2093174378 @default.
- W1972836161 hasRelatedWork W2316535789 @default.
- W1972836161 hasRelatedWork W2320063702 @default.
- W1972836161 hasRelatedWork W2329207811 @default.
- W1972836161 hasRelatedWork W2343177434 @default.
- W1972836161 hasRelatedWork W2388326482 @default.