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- W1972846467 abstract "An analysis of the Na+-dependent accumulation of 14C-γABA by subcellular brain particles indicates that the isotope moves sequentially from the suspending medium into a rapidly equilibrating pool and then into a slowly equilibrating pool. The total γABA content of the rapidly equilibrating pool increases with increasing Na+ concentration. The larger the rapidly equilibrating pool the more rapidly isotope moves into and out of the slowly equilibrating pool. The total γABA content of the slowly equilibrating pool decreases as a function of time, and the rate of decrease is increased by increasing the size of the rapidly equilibrating pool. The above findings are interpreted as evidence for a carrier-mediated diffusion process in which Na+ is required to activate the binding of γABA to the carrier. The sig-nificance of the Na+ activation is discussed in terms of a model for active transport." @default.
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- W1972846467 date "1965-03-01" @default.
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- W1972846467 title "A carrier-mediated transfer model for the accumulation of 14C γ-aminobutyric acid by subcellular brain particles" @default.
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- W1972846467 doi "https://doi.org/10.1016/0006-2952(65)90192-9" @default.
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