FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972846585> ?p ?o ?g. }

• W1972846585 endingPage "1011" @default.
• W1972846585 startingPage "1004" @default.
• W1972846585 abstract "The oral administration of neomycin or niacin as single-drug therapy can significantly lower total and low-density lipoprotein cholesterol concentrations in patients with type II hyperlipoproteinemia. However, in the majority of patients treated with one of these drugs as sole therapy plasma lipid and lipoprotein concentrations do not normalize. The effect of combined neomycin (2 g/day) and niacin (3 g/day) treatment on the plasma lipoprotein concentrations was determined in 25 type II hyperlipoproteinemic patients in a double-blind, randomized, placebo-controlled, crossover clinical trial. Treatment with neomycin was well tolerated by all 25 study patients and significantly reduced total and low-density lipoprotein cholesterol concentrations by 23% and 29%, respectively (p less than .05). In contrast to the well-tolerated neomycin regimen, 11 patients (44%) were unable to continue niacin treatment because of adverse side effects. In the 14 patients treated with both neomycin and niacin, niacin further lowered the concentrations of total and low-density lipoprotein cholesterol by 18% and 25%, respectively, and increased high-density lipoprotein cholesterol by 32% (p less than .05) compared with that in the patients receiving neomycin plus niacin placebo. Compared with diet-only therapy, combined treatment with neomycin plus niacin reduced the total plasma cholesterol concentration by 36%, low-density lipoprotein cholesterol by 45%, and the low-density lipoprotein/high-density lipoprotein ratio by 46% and it increased plasma high-density lipoprotein concentrations by 24% (p less than .001). During the study, 80% of all the study patients and 92% of the patients who complied with the combined regimen normalized their total and low-density lipoprotein concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W1972846585 created "2016-06-24" @default.
• W1972846585 creator A5006190722 @default.
• W1972846585 creator A5007091958 @default.
• W1972846585 creator A5010676062 @default.
• W1972846585 creator A5025873792 @default.
• W1972846585 creator A5037957960 @default.
• W1972846585 creator A5048179516 @default.
• W1972846585 creator A5058839578 @default.
• W1972846585 creator A5071684579 @default.
• W1972846585 creator A5073109157 @default.
• W1972846585 creator A5086929283 @default.
• W1972846585 date "1984-12-01" @default.
• W1972846585 modified "2023-09-27" @default.
• W1972846585 title "Normalization of plasma lipoprotein concentrations in patients with type II hyperlipoproteinemia by combined use of neomycin and niacin." @default.
• W1972846585 cites W1860487341 @default.
• W1972846585 cites W1938834933 @default.
• W1972846585 cites W1959995806 @default.
• W1972846585 cites W1976085323 @default.
• W1972846585 cites W1985656528 @default.
• W1972846585 cites W1989432650 @default.
• W1972846585 cites W2024512089 @default.
• W1972846585 cites W2079653677 @default.
• W1972846585 cites W2098804789 @default.
• W1972846585 cites W2146030284 @default.
• W1972846585 cites W2321230622 @default.
• W1972846585 cites W2326510067 @default.
• W1972846585 cites W4248021162 @default.
• W1972846585 cites W4254363271 @default.
• W1972846585 doi "https://doi.org/10.1161/01.cir.70.6.1004" @default.
• W1972846585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6388897" @default.
• W1972846585 hasPublicationYear "1984" @default.
• W1972846585 type Work @default.
• W1972846585 sameAs 1972846585 @default.
• W1972846585 citedByCount "38" @default.
• W1972846585 countsByYear W19728465852014 @default.
• W1972846585 countsByYear W19728465852015 @default.
• W1972846585 countsByYear W19728465852017 @default.
• W1972846585 crossrefType "journal-article" @default.
• W1972846585 hasAuthorship W1972846585A5006190722 @default.
• W1972846585 hasAuthorship W1972846585A5007091958 @default.
• W1972846585 hasAuthorship W1972846585A5010676062 @default.
• W1972846585 hasAuthorship W1972846585A5025873792 @default.
• W1972846585 hasAuthorship W1972846585A5037957960 @default.
• W1972846585 hasAuthorship W1972846585A5048179516 @default.
• W1972846585 hasAuthorship W1972846585A5058839578 @default.
• W1972846585 hasAuthorship W1972846585A5071684579 @default.
• W1972846585 hasAuthorship W1972846585A5073109157 @default.
• W1972846585 hasAuthorship W1972846585A5086929283 @default.
• W1972846585 hasBestOaLocation W19728465851 @default.
• W1972846585 hasConcept C126322002 @default.
• W1972846585 hasConcept C134018914 @default.
• W1972846585 hasConcept C142724271 @default.
• W1972846585 hasConcept C185592680 @default.
• W1972846585 hasConcept C204787440 @default.
• W1972846585 hasConcept C27081682 @default.
• W1972846585 hasConcept C2778163477 @default.
• W1972846585 hasConcept C2779841869 @default.
• W1972846585 hasConcept C2780072125 @default.
• W1972846585 hasConcept C2780092750 @default.
• W1972846585 hasConcept C501593827 @default.
• W1972846585 hasConcept C55493867 @default.
• W1972846585 hasConcept C71924100 @default.
• W1972846585 hasConcept C87813604 @default.
• W1972846585 hasConcept C90924648 @default.
• W1972846585 hasConcept C98274493 @default.
• W1972846585 hasConceptScore W1972846585C126322002 @default.
• W1972846585 hasConceptScore W1972846585C134018914 @default.
• W1972846585 hasConceptScore W1972846585C142724271 @default.
• W1972846585 hasConceptScore W1972846585C185592680 @default.
• W1972846585 hasConceptScore W1972846585C204787440 @default.
• W1972846585 hasConceptScore W1972846585C27081682 @default.
• W1972846585 hasConceptScore W1972846585C2778163477 @default.
• W1972846585 hasConceptScore W1972846585C2779841869 @default.
• W1972846585 hasConceptScore W1972846585C2780072125 @default.
• W1972846585 hasConceptScore W1972846585C2780092750 @default.
• W1972846585 hasConceptScore W1972846585C501593827 @default.
• W1972846585 hasConceptScore W1972846585C55493867 @default.
• W1972846585 hasConceptScore W1972846585C71924100 @default.
• W1972846585 hasConceptScore W1972846585C87813604 @default.
• W1972846585 hasConceptScore W1972846585C90924648 @default.
• W1972846585 hasConceptScore W1972846585C98274493 @default.
• W1972846585 hasIssue "6" @default.
• W1972846585 hasLocation W19728465851 @default.
• W1972846585 hasLocation W19728465852 @default.
• W1972846585 hasOpenAccess W1972846585 @default.
• W1972846585 hasPrimaryLocation W19728465851 @default.
• W1972846585 hasRelatedWork W111424409 @default.
• W1972846585 hasRelatedWork W1975912945 @default.
• W1972846585 hasRelatedWork W1994838191 @default.
• W1972846585 hasRelatedWork W2012462997 @default.
• W1972846585 hasRelatedWork W2028375480 @default.
• W1972846585 hasRelatedWork W2033921535 @default.
• W1972846585 hasRelatedWork W2056152299 @default.
• W1972846585 hasRelatedWork W2091911513 @default.
• W1972846585 hasRelatedWork W2118738696 @default.
• W1972846585 hasRelatedWork W1981719731 @default.
• W1972846585 hasVolume "70" @default.

• next