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- W1972861640 abstract "The multiplicity of heavy-chain variable-region (V H ) genes in mouse and human DNA has been estimated using a mouse heavy- (H) chain cDNA clone. We found about 10 hybridization components in mouse DNA and about 20 components in human DNA. Cross-hybridization studies of variable region (V) genes indicate that these components represent the numbers of genes within the V H subgroups of each of these species. The arrangement and rearrangement of the H-chain γ subclasses have been studied in order to assess possible mechanisms of the H-chain switch. Evidence has been found for rearrangement events involving the γ 2a and γ 2b constant-region (C H ) genes in DNA from cells making IgG2a and IgG2b respectively. In addition we found that cells making IgG2a lack detectable genes for γ 1 and γ 2b . Both sets of observations are discussed in relation to H-chain diversity and the switch." @default.
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- W1972861640 date "1980-03-01" @default.
- W1972861640 modified "2023-09-27" @default.
- W1972861640 title "The variability, arrangement, and rearrangement of immunoglobulin genes" @default.
- W1972861640 doi "https://doi.org/10.1139/o80-024" @default.
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