FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972873906> ?p ?o ?g. }

• W1972873906 endingPage "96" @default.
• W1972873906 startingPage "90" @default.
• W1972873906 abstract "Transient receptor potential ankyrin 1 (TRPA1) channel antagonists have suppressed mechanical hypersensitivity in peripheral neuropathy, while their effect on ongoing neuropathic pain is not yet known. Here, we assessed whether blocking the TRPA1 channel induces place-preference, an index for the relief of ongoing pain, in two experimental rat models of peripheral neuropathy. Diabetic neuropathy was induced by streptozotocin and spared nerve injury (SNI) model of neuropathy by ligation of two sciatic nerve branches. Conditioned place-preference (CPP) paradigm involved pairing of the drug treatment with one of the chambers of a CPP device once or four times, and the time spent in each chamber was recorded after conditioning sessions to reveal place-preference. The mechanical antihypersensitivity effect was assessed by the monofilament test immediately after the conditioning sessions. Intraperitoneally (30mg/kg; diabetic and SNI model) or intrathecally (10μg; diabetic model) administered Chembridge-5861528 (CHEM) was used as a selective TRPA1 channel antagonist. In diabetic and SNI models of neuropathy, CHEM failed to induce CPP at a dose that significantly attenuated mechanical hypersensitivity, independent of the route of drug administration or number of successive conditioning sessions. Intrathecal clonidine (an α2-adrenoceptor agonist; 10μg), in contrast, induced CPP in SNI but not control animals. The results indicate that ongoing pain, as revealed by CPP, is less sensitive to treatment by the TRPA1 channel antagonist than mechanical hypersensitivity in peripheral neuropathy." @default.
• W1972873906 created "2016-06-24" @default.
• W1972873906 creator A5005184266 @default.
• W1972873906 creator A5051314173 @default.
• W1972873906 creator A5051709752 @default.
• W1972873906 creator A5073685415 @default.
• W1972873906 creator A5075196242 @default.
• W1972873906 date "2013-03-01" @default.
• W1972873906 modified "2023-10-14" @default.
• W1972873906 title "Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy" @default.
• W1972873906 cites W1972216962 @default.
• W1972873906 cites W1974213802 @default.
• W1972873906 cites W1982324570 @default.
• W1972873906 cites W1982326881 @default.
• W1972873906 cites W1982661411 @default.
• W1972873906 cites W1983022687 @default.
• W1972873906 cites W1983037105 @default.
• W1972873906 cites W1983058725 @default.
• W1972873906 cites W1988588117 @default.
• W1972873906 cites W1988860455 @default.
• W1972873906 cites W1993231626 @default.
• W1972873906 cites W1995158095 @default.
• W1972873906 cites W1995723411 @default.
• W1972873906 cites W1996634599 @default.
• W1972873906 cites W1996723248 @default.
• W1972873906 cites W2012145735 @default.
• W1972873906 cites W2013940388 @default.
• W1972873906 cites W2031192054 @default.
• W1972873906 cites W2033570168 @default.
• W1972873906 cites W2033980432 @default.
• W1972873906 cites W2035257142 @default.
• W1972873906 cites W2047010161 @default.
• W1972873906 cites W2053037897 @default.
• W1972873906 cites W2054003118 @default.
• W1972873906 cites W2058500772 @default.
• W1972873906 cites W2069886558 @default.
• W1972873906 cites W2071531474 @default.
• W1972873906 cites W2074795582 @default.
• W1972873906 cites W2075575056 @default.
• W1972873906 cites W2077154875 @default.
• W1972873906 cites W2080998358 @default.
• W1972873906 cites W2087421621 @default.
• W1972873906 cites W2088867629 @default.
• W1972873906 cites W2090068017 @default.
• W1972873906 cites W2099970064 @default.
• W1972873906 cites W2120229762 @default.
• W1972873906 cites W2126238465 @default.
• W1972873906 cites W2130494624 @default.
• W1972873906 cites W2139686930 @default.
• W1972873906 cites W2145947130 @default.
• W1972873906 cites W2146975083 @default.
• W1972873906 cites W2164837602 @default.
• W1972873906 cites W2165281939 @default.
• W1972873906 cites W2288599350 @default.
• W1972873906 doi "https://doi.org/10.1016/j.pbb.2012.12.014" @default.
• W1972873906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23287802" @default.
• W1972873906 hasPublicationYear "2013" @default.
• W1972873906 type Work @default.
• W1972873906 sameAs 1972873906 @default.
• W1972873906 citedByCount "22" @default.
• W1972873906 countsByYear W19728739062013 @default.
• W1972873906 countsByYear W19728739062014 @default.
• W1972873906 countsByYear W19728739062015 @default.
• W1972873906 countsByYear W19728739062016 @default.
• W1972873906 countsByYear W19728739062017 @default.
• W1972873906 countsByYear W19728739062018 @default.
• W1972873906 countsByYear W19728739062020 @default.
• W1972873906 countsByYear W19728739062021 @default.
• W1972873906 countsByYear W19728739062022 @default.
• W1972873906 countsByYear W19728739062023 @default.
• W1972873906 crossrefType "journal-article" @default.
• W1972873906 hasAuthorship W1972873906A5005184266 @default.
• W1972873906 hasAuthorship W1972873906A5051314173 @default.
• W1972873906 hasAuthorship W1972873906A5051709752 @default.
• W1972873906 hasAuthorship W1972873906A5073685415 @default.
• W1972873906 hasAuthorship W1972873906A5075196242 @default.
• W1972873906 hasBestOaLocation W19728739062 @default.
• W1972873906 hasConcept C126322002 @default.
• W1972873906 hasConcept C134018914 @default.
• W1972873906 hasConcept C155164980 @default.
• W1972873906 hasConcept C16993767 @default.
• W1972873906 hasConcept C170493617 @default.
• W1972873906 hasConcept C185592680 @default.
• W1972873906 hasConcept C2775991916 @default.
• W1972873906 hasConcept C2776885963 @default.
• W1972873906 hasConcept C2777107010 @default.
• W1972873906 hasConcept C2777389121 @default.
• W1972873906 hasConcept C2778938600 @default.
• W1972873906 hasConcept C2779901536 @default.
• W1972873906 hasConcept C35124327 @default.
• W1972873906 hasConcept C42219234 @default.
• W1972873906 hasConcept C55493867 @default.
• W1972873906 hasConcept C555293320 @default.
• W1972873906 hasConcept C71924100 @default.
• W1972873906 hasConcept C90149880 @default.
• W1972873906 hasConcept C94412978 @default.
• W1972873906 hasConcept C98274493 @default.
• W1972873906 hasConceptScore W1972873906C126322002 @default.

• next