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- W1972882904 abstract "Abstract Perycit in a daily dose of 3 g lowers the cholesterol and triglyceride concentration in patients with different types of hyperlipidemia. Increasing the Perycitl® dose up to 4.5 g causes a further decrease of the lipid levels. A comparison between Perycit® and pure nicotinic acid showed that Perycit® in doses up to 6 g is more effective in reducing elevated cholesterol levels. The reduction of the plasma triglyceride and cholesterol concentration is explained by a decrease of VLD triglyceride and cholesterol concentration. The cholesterol concentration also decreased in the LD fraction but increased in the HD fraction. The K2 of the i.v. fat tolerance was not significantly influenced by the Perycit® treatment in the material studied and changes of the triglyceride concentration were not related to changes in K2, suggesting that the mechanism of action of Perycit® on the plasma lipids differs at least partly from that of pure nicotinic acid. As with nicotinic acid, elevated levels of transaminase and alkaline phosphatases were observed with Perycit® but the increases were not related to the dose used or to the duration of the treatment. Perycit®, in contrast to pure nicotinic acid, did not elevate the uric acid concentration in plasma." @default.
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- W1972882904 date "1974-01-01" @default.
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- W1972882904 title "Clinical and metabolic effects of pentaerythritol tetranicotinate (perycit®) and a comparison with plain nicotinic acid" @default.
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- W1972882904 doi "https://doi.org/10.1016/0021-9150(74)90044-6" @default.
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