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- W1972887923 abstract "Hippocampal ATP levels fell after both epileptogenic and non-epileptogenic fornical stimulation, and after perfusion with moderately high K+ concentrations. The effect of the latter was antagonized by Mg2+, which suggests it is secondary to synaptic stimulation. Higher K+ perfusing concentrations, such as are known to induce seizures, caused no change in hippocampal ATP. These results indicate that the relation between hippocampal ATP levels andthe genesis of seizures is not a specific one, but rather that ATP levels may fall simply as a consequence of enhanced electrical activity. Only after 25 min of epileptogenic stimulation was an increase of hippocam pal ATPase activity (both ouabain-sensitive and ouabain-insensitive) detected, which does not mean that the variations of ATP levels observed with shorter times of epilepsy, or with non-epileptogenic stimulation, may not be attributed to an increase of this enzymic activity, undetectable by this method of measurement." @default.
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- W1972887923 date "1973-07-01" @default.
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- W1972887923 title "Epilepsy and adenosinetriphosphate (ATP): Effect of electrical stimulation and high potassium perfusion on hippocampal ATP contents" @default.
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- W1972887923 doi "https://doi.org/10.1016/0006-8993(73)90146-7" @default.
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