FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972888501> ?p ?o ?g. }

• W1972888501 endingPage "28356" @default.
• W1972888501 startingPage "28350" @default.
• W1972888501 abstract "The 5′-flanking region of the gene coding for the γchain of human fibrinogen was characterized for its promoter activity. Reporter gene studies using chloramphenicol acetyltransferase as the indicator along with mutations in the DNA showed that a TATA-like sequence (-20 to -23 base pairs (bp)), a CAAT-like sequence (-54 to -57 bp), and an upstream stimulatory factor (USF) binding site (-66 to -77 bp) constitute a minimal promoter that mediates liver-specific expression of the gene. Electrophoretic gel mobility assays and antibody binding studies confirmed the interaction of USF with the binding site. An IL-6 responsive element with a sequence of CTGGAA located at -301 to -306 bp was shown to be a functional element in the IL-6 response. In contrast to the IL-6 responsive elements in the human α- and β-fibrinogen genes, the element in the gene for the γchain of human fibrinogen was unaffected by the presence or elevated levels of the β or δisoforms of the CCAAT/enhancer binding proteins. A negative element with sequence homology to several silencer elements was also identified in the region of -348 to -390 bp of the gene for the γchain of human fibrinogen. A comparison of the regulatory elements in the genes coding for all three chains in fibrinogen is also presented. The 5′-flanking region of the gene coding for the γchain of human fibrinogen was characterized for its promoter activity. Reporter gene studies using chloramphenicol acetyltransferase as the indicator along with mutations in the DNA showed that a TATA-like sequence (-20 to -23 base pairs (bp)), a CAAT-like sequence (-54 to -57 bp), and an upstream stimulatory factor (USF) binding site (-66 to -77 bp) constitute a minimal promoter that mediates liver-specific expression of the gene. Electrophoretic gel mobility assays and antibody binding studies confirmed the interaction of USF with the binding site. An IL-6 responsive element with a sequence of CTGGAA located at -301 to -306 bp was shown to be a functional element in the IL-6 response. In contrast to the IL-6 responsive elements in the human α- and β-fibrinogen genes, the element in the gene for the γchain of human fibrinogen was unaffected by the presence or elevated levels of the β or δisoforms of the CCAAT/enhancer binding proteins. A negative element with sequence homology to several silencer elements was also identified in the region of -348 to -390 bp of the gene for the γchain of human fibrinogen. A comparison of the regulatory elements in the genes coding for all three chains in fibrinogen is also presented." @default.
• W1972888501 created "2016-06-24" @default.
• W1972888501 creator A5003682380 @default.
• W1972888501 creator A5016382932 @default.
• W1972888501 creator A5065358447 @default.
• W1972888501 creator A5070437574 @default.
• W1972888501 creator A5083948389 @default.
• W1972888501 creator A5088738825 @default.
• W1972888501 date "1995-11-01" @default.
• W1972888501 modified "2023-09-27" @default.
• W1972888501 title "Characterization of the 5′-Flanking Region of the Gene for the γChain of Human Fibrinogen" @default.
• W1972888501 cites W1505987379 @default.
• W1972888501 cites W1537742882 @default.
• W1972888501 cites W1556587647 @default.
• W1972888501 cites W1626681731 @default.
• W1972888501 cites W1965372133 @default.
• W1972888501 cites W1982726429 @default.
• W1972888501 cites W1983852090 @default.
• W1972888501 cites W1986586769 @default.
• W1972888501 cites W1990989603 @default.
• W1972888501 cites W1999131239 @default.
• W1972888501 cites W2027500234 @default.
• W1972888501 cites W2037540469 @default.
• W1972888501 cites W2040193953 @default.
• W1972888501 cites W2049672602 @default.
• W1972888501 cites W2053659427 @default.
• W1972888501 cites W2057007008 @default.
• W1972888501 cites W2062923310 @default.
• W1972888501 cites W2066447453 @default.
• W1972888501 cites W2088622701 @default.
• W1972888501 cites W2092608701 @default.
• W1972888501 cites W2110015271 @default.
• W1972888501 cites W2128746215 @default.
• W1972888501 cites W2138270253 @default.
• W1972888501 cites W2166801871 @default.
• W1972888501 cites W2170005346 @default.
• W1972888501 doi "https://doi.org/10.1074/jbc.270.47.28350" @default.
• W1972888501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7499336" @default.
• W1972888501 hasPublicationYear "1995" @default.
• W1972888501 type Work @default.
• W1972888501 sameAs 1972888501 @default.
• W1972888501 citedByCount "46" @default.
• W1972888501 countsByYear W19728885012012 @default.
• W1972888501 countsByYear W19728885012013 @default.
• W1972888501 countsByYear W19728885012014 @default.
• W1972888501 countsByYear W19728885012021 @default.
• W1972888501 crossrefType "journal-article" @default.
• W1972888501 hasAuthorship W1972888501A5003682380 @default.
• W1972888501 hasAuthorship W1972888501A5016382932 @default.
• W1972888501 hasAuthorship W1972888501A5065358447 @default.
• W1972888501 hasAuthorship W1972888501A5070437574 @default.
• W1972888501 hasAuthorship W1972888501A5083948389 @default.
• W1972888501 hasAuthorship W1972888501A5088738825 @default.
• W1972888501 hasBestOaLocation W19728885011 @default.
• W1972888501 hasConcept C101762097 @default.
• W1972888501 hasConcept C104317684 @default.
• W1972888501 hasConcept C111936080 @default.
• W1972888501 hasConcept C150194340 @default.
• W1972888501 hasConcept C153911025 @default.
• W1972888501 hasConcept C161733203 @default.
• W1972888501 hasConcept C165864922 @default.
• W1972888501 hasConcept C167625842 @default.
• W1972888501 hasConcept C186493320 @default.
• W1972888501 hasConcept C21592294 @default.
• W1972888501 hasConcept C2780730277 @default.
• W1972888501 hasConcept C54355233 @default.
• W1972888501 hasConcept C54985914 @default.
• W1972888501 hasConcept C65888428 @default.
• W1972888501 hasConcept C86803240 @default.
• W1972888501 hasConcept C91779695 @default.
• W1972888501 hasConceptScore W1972888501C101762097 @default.
• W1972888501 hasConceptScore W1972888501C104317684 @default.
• W1972888501 hasConceptScore W1972888501C111936080 @default.
• W1972888501 hasConceptScore W1972888501C150194340 @default.
• W1972888501 hasConceptScore W1972888501C153911025 @default.
• W1972888501 hasConceptScore W1972888501C161733203 @default.
• W1972888501 hasConceptScore W1972888501C165864922 @default.
• W1972888501 hasConceptScore W1972888501C167625842 @default.
• W1972888501 hasConceptScore W1972888501C186493320 @default.
• W1972888501 hasConceptScore W1972888501C21592294 @default.
• W1972888501 hasConceptScore W1972888501C2780730277 @default.
• W1972888501 hasConceptScore W1972888501C54355233 @default.
• W1972888501 hasConceptScore W1972888501C54985914 @default.
• W1972888501 hasConceptScore W1972888501C65888428 @default.
• W1972888501 hasConceptScore W1972888501C86803240 @default.
• W1972888501 hasConceptScore W1972888501C91779695 @default.
• W1972888501 hasIssue "47" @default.
• W1972888501 hasLocation W19728885011 @default.
• W1972888501 hasOpenAccess W1972888501 @default.
• W1972888501 hasPrimaryLocation W19728885011 @default.
• W1972888501 hasRelatedWork W1972681927 @default.
• W1972888501 hasRelatedWork W1995412965 @default.
• W1972888501 hasRelatedWork W2025674096 @default.
• W1972888501 hasRelatedWork W2045244603 @default.
• W1972888501 hasRelatedWork W2052472936 @default.
• W1972888501 hasRelatedWork W2073042226 @default.
• W1972888501 hasRelatedWork W2075818573 @default.
• W1972888501 hasRelatedWork W2113093767 @default.

• next