FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972898308> ?p ?o ?g. }

• W1972898308 endingPage "F843" @default.
• W1972898308 startingPage "F833" @default.
• W1972898308 abstract "The kidney adjusts K + excretion to match intake in part by regulation of the activity of apical K + secretory channels, including renal outer medullary K + (ROMK)-like K + channels, in the cortical collecting duct (CCD). ANG II inhibits ROMK channels via the ANG II type 1 receptor (AT 1 R) during dietary K + restriction. Because AT 1 Rs and ANG II type 2 receptors (AT 2 Rs) generally function in an antagonistic manner, we sought to characterize the regulation of ROMK channels by the AT 2 R. Patch-clamp experiments revealed that ANG II increased ROMK channel activity in CCDs isolated from high-K + (HK)-fed but not normal K + (NK)-fed rats. This response was blocked by PD-123319, an AT 2 R antagonist, but not by losartan, an AT 1 R antagonist, and was mimicked by the AT 2 R agonist CGP-42112. Nitric oxide (NO) synthase is present in CCD cells that express ROMK channels. Blockade of NO synthase with N-nitro-l-arginine methyl ester and free NO with 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt completely abolished ANG II-stimulated ROMK channel activity. NO enhances the synthesis of cGMP, which inhibits phosphodiesterases (PDEs) that normally degrade cAMP; cAMP increases ROMK channel activity. Pretreatment of CCDs with IBMX, a broad-spectrum PDE inhibitor, or cilostamide, a PDE3 inhibitor, abolished the stimulatory effect of ANG II on ROMK channels. Furthermore, PKA inhibitor peptide, but not an activator of the exchange protein directly activated by cAMP (Epac), also prevented the stimulatory effect of ANG II. We conclude that ANG II acts at the AT 2 R to stimulate ROMK channel activity in CCDs from HK-fed rats, a response opposite to that mediated by the AT 1 R in dietary K + -restricted animals, via a NO/cGMP pathway linked to a cAMP-PKA pathway." @default.
• W1972898308 created "2016-06-24" @default.
• W1972898308 creator A5005780035 @default.
• W1972898308 creator A5008035709 @default.
• W1972898308 creator A5010653984 @default.
• W1972898308 creator A5011582040 @default.
• W1972898308 creator A5019978299 @default.
• W1972898308 creator A5032533121 @default.
• W1972898308 creator A5049888042 @default.
• W1972898308 creator A5053221803 @default.
• W1972898308 creator A5053994526 @default.
• W1972898308 creator A5056353096 @default.
• W1972898308 creator A5072528995 @default.
• W1972898308 date "2014-10-01" @default.
• W1972898308 modified "2023-10-02" @default.
• W1972898308 title "Angiotensin II type 2 receptor regulates ROMK-like K+ channel activity in the renal cortical collecting duct during high dietary K+ adaptation" @default.
• W1972898308 cites W1486907197 @default.
• W1972898308 cites W1761458604 @default.
• W1972898308 cites W1852486766 @default.
• W1972898308 cites W1965599418 @default.
• W1972898308 cites W1973519389 @default.
• W1972898308 cites W1978998472 @default.
• W1972898308 cites W1979634582 @default.
• W1972898308 cites W1980182090 @default.
• W1972898308 cites W1981839032 @default.
• W1972898308 cites W1995892517 @default.
• W1972898308 cites W2021662148 @default.
• W1972898308 cites W2024919412 @default.
• W1972898308 cites W2025098274 @default.
• W1972898308 cites W2031647568 @default.
• W1972898308 cites W2034705839 @default.
• W1972898308 cites W2035690299 @default.
• W1972898308 cites W2037104507 @default.
• W1972898308 cites W2052326078 @default.
• W1972898308 cites W2053980585 @default.
• W1972898308 cites W2061565807 @default.
• W1972898308 cites W2063716341 @default.
• W1972898308 cites W2068847639 @default.
• W1972898308 cites W2070847837 @default.
• W1972898308 cites W2077755388 @default.
• W1972898308 cites W2079773628 @default.
• W1972898308 cites W2080712763 @default.
• W1972898308 cites W2098541441 @default.
• W1972898308 cites W2105300577 @default.
• W1972898308 cites W2105959687 @default.
• W1972898308 cites W2106850420 @default.
• W1972898308 cites W2107277218 @default.
• W1972898308 cites W2118249193 @default.
• W1972898308 cites W2118657621 @default.
• W1972898308 cites W2119903978 @default.
• W1972898308 cites W2120285739 @default.
• W1972898308 cites W2121619203 @default.
• W1972898308 cites W2125429703 @default.
• W1972898308 cites W2127428401 @default.
• W1972898308 cites W2133421404 @default.
• W1972898308 cites W2134168892 @default.
• W1972898308 cites W2134319114 @default.
• W1972898308 cites W2135982229 @default.
• W1972898308 cites W2137895593 @default.
• W1972898308 cites W2138932948 @default.
• W1972898308 cites W2142197398 @default.
• W1972898308 cites W2142889758 @default.
• W1972898308 cites W2146413835 @default.
• W1972898308 cites W2151820589 @default.
• W1972898308 cites W2162591155 @default.
• W1972898308 cites W2167740142 @default.
• W1972898308 cites W2168237435 @default.
• W1972898308 cites W2171305591 @default.
• W1972898308 cites W2181302308 @default.
• W1972898308 cites W2181592167 @default.
• W1972898308 cites W2182749815 @default.
• W1972898308 cites W2211384723 @default.
• W1972898308 cites W2226605642 @default.
• W1972898308 cites W2238548051 @default.
• W1972898308 cites W2265391412 @default.
• W1972898308 cites W2322898676 @default.
• W1972898308 cites W2341354300 @default.
• W1972898308 cites W2401231806 @default.
• W1972898308 cites W2408029684 @default.
• W1972898308 cites W2418687657 @default.
• W1972898308 cites W2472948405 @default.
• W1972898308 doi "https://doi.org/10.1152/ajprenal.00141.2014" @default.
• W1972898308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4187043" @default.
• W1972898308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25100281" @default.
• W1972898308 hasPublicationYear "2014" @default.
• W1972898308 type Work @default.
• W1972898308 sameAs 1972898308 @default.
• W1972898308 citedByCount "17" @default.
• W1972898308 countsByYear W19728983082014 @default.
• W1972898308 countsByYear W19728983082015 @default.
• W1972898308 countsByYear W19728983082016 @default.
• W1972898308 countsByYear W19728983082017 @default.
• W1972898308 countsByYear W19728983082018 @default.
• W1972898308 countsByYear W19728983082019 @default.
• W1972898308 countsByYear W19728983082020 @default.
• W1972898308 countsByYear W19728983082021 @default.
• W1972898308 countsByYear W19728983082022 @default.
• W1972898308 crossrefType "journal-article" @default.

• next