Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972928350> ?p ?o ?g. }
- W1972928350 endingPage "619" @default.
- W1972928350 startingPage "612" @default.
- W1972928350 abstract "Correlations were sought between local cerebral metabolic rates (LCMRs) for glucose in various regions of the cortex, determined in premortem PET scans, with the regional activities of choline acetyltransferase (ChAT), acetylcholinesterase (AChE), β-glucuronidase (Gluc, a probable index of reactive gliosis), and phosphate-activated glutaminase (PAG, a possible indice of the large pyramidal neurons) measured on postmortem tissue. Significant negative correlations between LCMRs and Gluc activities were found in 6 PET-scanned cases of Alzheimer disease (AD), and positive correlations of LCMRs with PAG were found in 5. By contrast, a positive correlation with ChAT and AChE was found in only 1. The results are consistent with the metabolic deficits in AD being primarily a reflection of local neuronal loss and gliosis. Similar data on two cases of Huntington's disease showed no significant correlations, while 1 patient with Parkinson dementia showed a significant (negative) correlation only with Gluc." @default.
- W1972928350 created "2016-06-24" @default.
- W1972928350 creator A5023404722 @default.
- W1972928350 creator A5026148743 @default.
- W1972928350 creator A5057901720 @default.
- W1972928350 creator A5072830866 @default.
- W1972928350 creator A5077104076 @default.
- W1972928350 date "1990-12-01" @default.
- W1972928350 modified "2023-09-23" @default.
- W1972928350 title "Correlations of regional postmortem enzyme activities with premortem local glucose metabolic rates in alzheimer's disease" @default.
- W1972928350 cites W1511379621 @default.
- W1972928350 cites W1559777560 @default.
- W1972928350 cites W1775749144 @default.
- W1972928350 cites W1821885973 @default.
- W1972928350 cites W1857708765 @default.
- W1972928350 cites W1910339266 @default.
- W1972928350 cites W1916190008 @default.
- W1972928350 cites W1976146524 @default.
- W1972928350 cites W1982505761 @default.
- W1972928350 cites W1992598058 @default.
- W1972928350 cites W1997498976 @default.
- W1972928350 cites W1998991851 @default.
- W1972928350 cites W2002401411 @default.
- W1972928350 cites W2008538896 @default.
- W1972928350 cites W2013512726 @default.
- W1972928350 cites W2015497653 @default.
- W1972928350 cites W2016507593 @default.
- W1972928350 cites W2018390003 @default.
- W1972928350 cites W2024154183 @default.
- W1972928350 cites W2024431245 @default.
- W1972928350 cites W2037438491 @default.
- W1972928350 cites W2037636017 @default.
- W1972928350 cites W2053701788 @default.
- W1972928350 cites W2056983787 @default.
- W1972928350 cites W2065788950 @default.
- W1972928350 cites W2068948419 @default.
- W1972928350 cites W2072777757 @default.
- W1972928350 cites W2076672023 @default.
- W1972928350 cites W2077035051 @default.
- W1972928350 cites W2081665652 @default.
- W1972928350 cites W2082472922 @default.
- W1972928350 cites W2083736782 @default.
- W1972928350 cites W2087221633 @default.
- W1972928350 cites W2104902751 @default.
- W1972928350 cites W2109572934 @default.
- W1972928350 cites W2152892581 @default.
- W1972928350 cites W2154584808 @default.
- W1972928350 cites W2338592719 @default.
- W1972928350 cites W2411997763 @default.
- W1972928350 cites W323342838 @default.
- W1972928350 cites W95415154 @default.
- W1972928350 doi "https://doi.org/10.1002/jnr.490270422" @default.
- W1972928350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2079721" @default.
- W1972928350 hasPublicationYear "1990" @default.
- W1972928350 type Work @default.
- W1972928350 sameAs 1972928350 @default.
- W1972928350 citedByCount "43" @default.
- W1972928350 countsByYear W19729283502012 @default.
- W1972928350 countsByYear W19729283502014 @default.
- W1972928350 countsByYear W19729283502015 @default.
- W1972928350 countsByYear W19729283502016 @default.
- W1972928350 countsByYear W19729283502017 @default.
- W1972928350 countsByYear W19729283502018 @default.
- W1972928350 countsByYear W19729283502021 @default.
- W1972928350 crossrefType "journal-article" @default.
- W1972928350 hasAuthorship W1972928350A5023404722 @default.
- W1972928350 hasAuthorship W1972928350A5026148743 @default.
- W1972928350 hasAuthorship W1972928350A5057901720 @default.
- W1972928350 hasAuthorship W1972928350A5072830866 @default.
- W1972928350 hasAuthorship W1972928350A5077104076 @default.
- W1972928350 hasConcept C126322002 @default.
- W1972928350 hasConcept C134018914 @default.
- W1972928350 hasConcept C142724271 @default.
- W1972928350 hasConcept C169760540 @default.
- W1972928350 hasConcept C181199279 @default.
- W1972928350 hasConcept C185592680 @default.
- W1972928350 hasConcept C198399640 @default.
- W1972928350 hasConcept C2777682930 @default.
- W1972928350 hasConcept C2778816929 @default.
- W1972928350 hasConcept C2779134260 @default.
- W1972928350 hasConcept C2779483572 @default.
- W1972928350 hasConcept C502032728 @default.
- W1972928350 hasConcept C529278444 @default.
- W1972928350 hasConcept C55493867 @default.
- W1972928350 hasConcept C71924100 @default.
- W1972928350 hasConcept C86803240 @default.
- W1972928350 hasConceptScore W1972928350C126322002 @default.
- W1972928350 hasConceptScore W1972928350C134018914 @default.
- W1972928350 hasConceptScore W1972928350C142724271 @default.
- W1972928350 hasConceptScore W1972928350C169760540 @default.
- W1972928350 hasConceptScore W1972928350C181199279 @default.
- W1972928350 hasConceptScore W1972928350C185592680 @default.
- W1972928350 hasConceptScore W1972928350C198399640 @default.
- W1972928350 hasConceptScore W1972928350C2777682930 @default.
- W1972928350 hasConceptScore W1972928350C2778816929 @default.
- W1972928350 hasConceptScore W1972928350C2779134260 @default.
- W1972928350 hasConceptScore W1972928350C2779483572 @default.
- W1972928350 hasConceptScore W1972928350C502032728 @default.