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• W1972929586 abstract "Tumour necrosis factor (TNF) contributes to the pathogenesis of bone marrow failure in Fanconi anaemia (FA) patients. The sensitivity of haematopoietic cells from FA, complementation group A (FANCA) subjects, who represent the majority of FA patients, to TNF-related apoptosis-inducing ligand (TRAIL) is unknown. The human lymphoblastoid FANCA HSC072 cell line and the genetically corrected counterpart HSC072FANCA-neo were tested for apoptoptic response to TRAIL using flow cytometry and Western blotting. FANCA cells were more sensitive to TRAIL-induced apoptosis than their corrected counterparts, indicating that TRAIL negatively regulates haematopoietic FANCA cell lines. This effect involved poly(ADP-ribose) polymerase-1 cleavage and caspase-8 activation." @default.
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• W1972929586 date "2007-01-01" @default.
• W1972929586 modified "2023-10-14" @default.
• W1972929586 title "Human Fanconi A cells are susceptible to TRAIL-induced apoptosis" @default.
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• W1972929586 doi "https://doi.org/10.1111/j.1365-2141.2006.06432.x" @default.
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