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- W1972932214 abstract "Pentoxifylline and propentofylline are potent drugs used in impaired blood-flow pathologies. As an approach to understand their mode of action we studied their influence on protoporphyrin-photosensitized damage of the human red cell membrane. Both compounds are shown to exert a strong protection against the increase in osmotic fragility of the red cell which follows their irradiation at 390 nm in the presence of protoporphyrin. They do not, however, prevent cross-linking of the membrane skeleton proteins, which occurs slowly following irradiation. The results emphasize the ability of pentoxifylline and propentofylline to scavenge toxic photoactivated radicals, a property which could explain their mode of action in vivo. We also show that the two methyl xanthine derivatives considered in this study significantly protect red cells from hemolysis and spontaneous microvesiculization of their plasma membrane, which normally occurs when whole blood is stored for several weeks." @default.
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- W1972932214 date "1990-01-01" @default.
- W1972932214 modified "2023-09-26" @default.
- W1972932214 title "Protective role of pentoxifylline and propentofylline against the increase in osmotic fragility of the human red cell induced by protoporphyrin photosensitization" @default.
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- W1972932214 doi "https://doi.org/10.1002/ddr.430210106" @default.
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