FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972936776> ?p ?o ?g. }

• W1972936776 endingPage "100" @default.
• W1972936776 startingPage "93" @default.
• W1972936776 abstract "Based on previous in vivo and in situ studies showing that tetracyclines possess antidegenerative effects on cartilage in conjunction with a reduced proteoglycan (PG) loss from the extracellular matrix, we investigated the effects of doxycycline, minocycline and tetracycline on the degradation and biosynthesis of PGs by bovine articular cartilage expiants, both in vitro and in situ. Doxycycline, minocycline and tetracycline dose dependently, although weakly, inhibited PG degrading matrix metalloproteinases (MMPs) in vitro, when tested at concentrations ranging from 1 to 100 μM. Ro 31–4724 proved to be a potent inhibitor of MMP proteoglycanases (ic50 value 1.5 nM). Only at a concentration of 100 μM did doxycycline and minocycline significantly inhibit the interleukin-1 (IL-1)-induced augmentation of PG loss from cartilage expiants into the nutrient media. The tetracyclines did not modulate the IL-1-mediated reduced aggregability of PGs, whereas 10 μM Ro 31–4724 partially restored the aggregability of PGs ex vivo. Tetracycline even at this high concentration was ineffective. Compared to the effects of the MMP inhibitor Ro 31–4724, treatment with tetracyclines at therapeutic serum levels of 1 or 10 μM was minimal, with little or no effect on cartilage proteoglycanases and PG biosynthesis. In our experiments, tetracyclines and Ro 31–4724 at doses evaluated had no cytotoxic effects on chondrocytes." @default.
• W1972936776 created "2016-06-24" @default.
• W1972936776 creator A5052639849 @default.
• W1972936776 creator A5066113300 @default.
• W1972936776 creator A5077587176 @default.
• W1972936776 date "1998-01-01" @default.
• W1972936776 modified "2023-10-03" @default.
• W1972936776 title "Pharmacological effect of tetracyclines on proteoglycanases from interleukin-1 -treated articular cartilage" @default.
• W1972936776 cites W1423515969 @default.
• W1972936776 cites W1544601459 @default.
• W1972936776 cites W1559462600 @default.
• W1972936776 cites W1684987198 @default.
• W1972936776 cites W1712774648 @default.
• W1972936776 cites W1808369276 @default.
• W1972936776 cites W1938535455 @default.
• W1972936776 cites W1963698879 @default.
• W1972936776 cites W1971417904 @default.
• W1972936776 cites W1977837843 @default.
• W1972936776 cites W1979972616 @default.
• W1972936776 cites W1980480613 @default.
• W1972936776 cites W1981390055 @default.
• W1972936776 cites W1984837363 @default.
• W1972936776 cites W1996413321 @default.
• W1972936776 cites W1996716065 @default.
• W1972936776 cites W1999298587 @default.
• W1972936776 cites W2009898623 @default.
• W1972936776 cites W2017796558 @default.
• W1972936776 cites W2022582010 @default.
• W1972936776 cites W2025391900 @default.
• W1972936776 cites W2032255522 @default.
• W1972936776 cites W2033092310 @default.
• W1972936776 cites W2040192156 @default.
• W1972936776 cites W2045503348 @default.
• W1972936776 cites W2046683941 @default.
• W1972936776 cites W2048259286 @default.
• W1972936776 cites W2049339178 @default.
• W1972936776 cites W2056743394 @default.
• W1972936776 cites W2057558046 @default.
• W1972936776 cites W2058685987 @default.
• W1972936776 cites W2060955746 @default.
• W1972936776 cites W2074016505 @default.
• W1972936776 cites W2096834315 @default.
• W1972936776 cites W2097525941 @default.
• W1972936776 cites W2106284778 @default.
• W1972936776 cites W2109658199 @default.
• W1972936776 cites W2111052817 @default.
• W1972936776 cites W2112753909 @default.
• W1972936776 cites W2116969857 @default.
• W1972936776 cites W2166464018 @default.
• W1972936776 cites W2204294987 @default.
• W1972936776 doi "https://doi.org/10.1016/s0006-2952(97)00383-3" @default.
• W1972936776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9413935" @default.
• W1972936776 hasPublicationYear "1998" @default.
• W1972936776 type Work @default.
• W1972936776 sameAs 1972936776 @default.
• W1972936776 citedByCount "25" @default.
• W1972936776 countsByYear W19729367762012 @default.
• W1972936776 countsByYear W19729367762013 @default.
• W1972936776 countsByYear W19729367762015 @default.
• W1972936776 countsByYear W19729367762016 @default.
• W1972936776 countsByYear W19729367762020 @default.
• W1972936776 crossrefType "journal-article" @default.
• W1972936776 hasAuthorship W1972936776A5052639849 @default.
• W1972936776 hasAuthorship W1972936776A5066113300 @default.
• W1972936776 hasAuthorship W1972936776A5077587176 @default.
• W1972936776 hasConcept C105702510 @default.
• W1972936776 hasConcept C109523444 @default.
• W1972936776 hasConcept C150903083 @default.
• W1972936776 hasConcept C153911025 @default.
• W1972936776 hasConcept C185592680 @default.
• W1972936776 hasConcept C189165786 @default.
• W1972936776 hasConcept C202751555 @default.
• W1972936776 hasConcept C207001950 @default.
• W1972936776 hasConcept C26291073 @default.
• W1972936776 hasConcept C2777179404 @default.
• W1972936776 hasConcept C2778275353 @default.
• W1972936776 hasConcept C2779335624 @default.
• W1972936776 hasConcept C2780550940 @default.
• W1972936776 hasConcept C2780923616 @default.
• W1972936776 hasConcept C501593827 @default.
• W1972936776 hasConcept C55493867 @default.
• W1972936776 hasConcept C86803240 @default.
• W1972936776 hasConcept C98274493 @default.
• W1972936776 hasConceptScore W1972936776C105702510 @default.
• W1972936776 hasConceptScore W1972936776C109523444 @default.
• W1972936776 hasConceptScore W1972936776C150903083 @default.
• W1972936776 hasConceptScore W1972936776C153911025 @default.
• W1972936776 hasConceptScore W1972936776C185592680 @default.
• W1972936776 hasConceptScore W1972936776C189165786 @default.
• W1972936776 hasConceptScore W1972936776C202751555 @default.
• W1972936776 hasConceptScore W1972936776C207001950 @default.
• W1972936776 hasConceptScore W1972936776C26291073 @default.
• W1972936776 hasConceptScore W1972936776C2777179404 @default.
• W1972936776 hasConceptScore W1972936776C2778275353 @default.
• W1972936776 hasConceptScore W1972936776C2779335624 @default.
• W1972936776 hasConceptScore W1972936776C2780550940 @default.
• W1972936776 hasConceptScore W1972936776C2780923616 @default.
• W1972936776 hasConceptScore W1972936776C501593827 @default.

• next