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- W1972947470 abstract "Some factors that enhance or inhibit the bioeffects of ultrasound (US) were investigated and possible mechanisms explored. The findings: (1) Low intensity, nonthermal US enhanced hyperthermia-induced apoptosis. (2) A nonlethal hypotonia enhanced the US-induced cell killing due to increased susceptibility of the swollen cells and inhibited repair of damaged membranes. (3) Some agents, including known anticancer drugs and a temperature-dependent free radical generator, enhanced the US-induced bioeffects. (Increased uptake of the agent was likely involved.) (4) Bioeffects can be enhanced by echo-contrast agents (ECAs) and can be inhibited by carbon dioxide, suggesting the role of cavitation in the bioeffects. (Mechanical membrane damage is apparently a pivotal event in the bioeffects.); and (5) The cell killing significantly declined at densities 10×106/ml and above. At 2×106 cells/ml, incubation inhibited cell killing time dependently. However, at the inhibited conditions, cell killing was observed when cells were sonicated with ECA. In summary, enhancing factors are potentially useful for therapy, while inhibitory factors are important in modulating the effects of US on the normal cells. All these factors are vital in understanding the level of efficacy of therapeutic US and the level of safety on the use of US in diagnosis." @default.
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- W1972947470 date "2004-10-01" @default.
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- W1972947470 title "Biological effects of low intensity therapeutic ultrasound in vitro: the potentials for therapy and the implications on safety of diagnostic ultrasound" @default.
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- W1972947470 doi "https://doi.org/10.1016/j.ics.2004.07.031" @default.
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