Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972960900> ?p ?o ?g. }
- W1972960900 endingPage "1144" @default.
- W1972960900 startingPage "1136" @default.
- W1972960900 abstract "In HIV infection, CD4 responses to opportunistic pathogens such as Candida albicans are lost early, but CMV-specific CD4 response persists. Little is currently known about HIV infection of CD4 T cells of different pathogen/antigen specificities. CFSE-labeled PBMCs were stimulated with CMV, tetanus toxoid (TT), and C albicans antigens and subsequently exposed to HIV. HIV infection was monitored by intracellular p24 in CFSE(low) population. We found that although TT- and C albicans-specific CD4 T cells were permissive, CMV-specific CD4 T cells were highly resistant to both R5 and X4 HIV. Quantification of HIV DNA in CFSE(low) cells showed a reduction of strong-stop and full-length DNA in CMV-specific cells compared with TT- and C albicans-specific cells. β-Chemokine neutralization enhanced HIV infection in TT- and C albicans-specific cells, whereas HIV infection in CMV-specific cells remained low despite increased entry by β-chemokine neutralization, suggesting postentry HIV restriction by CMV-specific cells. Microarray analysis (Gene Expression Omnibus accession number: GSE42853) revealed distinct transcriptional profiles that involved selective up-regulation of comprehensive innate antiviral genes in CMV-specific cells, whereas TT- and C albicans-specific cells mainly up-regulated Th17 inflammatory response. Our data suggest a mechanism for the persistence of CMV-specific CD4 response and earlier loss of mucosal Th17-associated TT- and C albicans-specific CD4 response in AIDS." @default.
- W1972960900 created "2016-06-24" @default.
- W1972960900 creator A5001108158 @default.
- W1972960900 creator A5001916237 @default.
- W1972960900 creator A5032298579 @default.
- W1972960900 creator A5036265394 @default.
- W1972960900 creator A5051957767 @default.
- W1972960900 creator A5061456713 @default.
- W1972960900 creator A5061838905 @default.
- W1972960900 creator A5066946912 @default.
- W1972960900 creator A5077297348 @default.
- W1972960900 creator A5082702766 @default.
- W1972960900 creator A5084891019 @default.
- W1972960900 creator A5089233990 @default.
- W1972960900 creator A5090012017 @default.
- W1972960900 date "2013-02-14" @default.
- W1972960900 modified "2023-10-12" @default.
- W1972960900 title "Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection" @default.
- W1972960900 cites W1663779312 @default.
- W1972960900 cites W1873207987 @default.
- W1972960900 cites W1917913929 @default.
- W1972960900 cites W1965591672 @default.
- W1972960900 cites W1979724803 @default.
- W1972960900 cites W1984009950 @default.
- W1972960900 cites W1984811742 @default.
- W1972960900 cites W1984999783 @default.
- W1972960900 cites W1992991204 @default.
- W1972960900 cites W1996770717 @default.
- W1972960900 cites W1999002546 @default.
- W1972960900 cites W1999396723 @default.
- W1972960900 cites W2003823192 @default.
- W1972960900 cites W2004937435 @default.
- W1972960900 cites W2010172624 @default.
- W1972960900 cites W2016488838 @default.
- W1972960900 cites W2025481552 @default.
- W1972960900 cites W2028478483 @default.
- W1972960900 cites W2031913105 @default.
- W1972960900 cites W2035663713 @default.
- W1972960900 cites W2048232382 @default.
- W1972960900 cites W2053094468 @default.
- W1972960900 cites W2075081228 @default.
- W1972960900 cites W2075345074 @default.
- W1972960900 cites W2076039408 @default.
- W1972960900 cites W2077620427 @default.
- W1972960900 cites W2080350299 @default.
- W1972960900 cites W2086876304 @default.
- W1972960900 cites W2090197666 @default.
- W1972960900 cites W2092397134 @default.
- W1972960900 cites W2107235439 @default.
- W1972960900 cites W2109972881 @default.
- W1972960900 cites W2115377212 @default.
- W1972960900 cites W2116830437 @default.
- W1972960900 cites W2121449768 @default.
- W1972960900 cites W2124114936 @default.
- W1972960900 cites W2132007861 @default.
- W1972960900 cites W2136626725 @default.
- W1972960900 cites W2143013829 @default.
- W1972960900 cites W2143597049 @default.
- W1972960900 cites W2150645172 @default.
- W1972960900 cites W2152074759 @default.
- W1972960900 cites W2164195233 @default.
- W1972960900 cites W2165241820 @default.
- W1972960900 cites W2166696946 @default.
- W1972960900 cites W2336541137 @default.
- W1972960900 cites W2615227430 @default.
- W1972960900 cites W4294107304 @default.
- W1972960900 doi "https://doi.org/10.1182/blood-2012-07-446278" @default.
- W1972960900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3575757" @default.
- W1972960900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23258923" @default.
- W1972960900 hasPublicationYear "2013" @default.
- W1972960900 type Work @default.
- W1972960900 sameAs 1972960900 @default.
- W1972960900 citedByCount "36" @default.
- W1972960900 countsByYear W19729609002013 @default.
- W1972960900 countsByYear W19729609002014 @default.
- W1972960900 countsByYear W19729609002015 @default.
- W1972960900 countsByYear W19729609002016 @default.
- W1972960900 countsByYear W19729609002017 @default.
- W1972960900 countsByYear W19729609002018 @default.
- W1972960900 countsByYear W19729609002019 @default.
- W1972960900 countsByYear W19729609002020 @default.
- W1972960900 countsByYear W19729609002021 @default.
- W1972960900 countsByYear W19729609002022 @default.
- W1972960900 countsByYear W19729609002023 @default.
- W1972960900 crossrefType "journal-article" @default.
- W1972960900 hasAuthorship W1972960900A5001108158 @default.
- W1972960900 hasAuthorship W1972960900A5001916237 @default.
- W1972960900 hasAuthorship W1972960900A5032298579 @default.
- W1972960900 hasAuthorship W1972960900A5036265394 @default.
- W1972960900 hasAuthorship W1972960900A5051957767 @default.
- W1972960900 hasAuthorship W1972960900A5061456713 @default.
- W1972960900 hasAuthorship W1972960900A5061838905 @default.
- W1972960900 hasAuthorship W1972960900A5066946912 @default.
- W1972960900 hasAuthorship W1972960900A5077297348 @default.
- W1972960900 hasAuthorship W1972960900A5082702766 @default.
- W1972960900 hasAuthorship W1972960900A5084891019 @default.
- W1972960900 hasAuthorship W1972960900A5089233990 @default.
- W1972960900 hasAuthorship W1972960900A5090012017 @default.