Matches in SemOpenAlex for { <https://semopenalex.org/work/W1972968002> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1972968002 endingPage "112" @default.
- W1972968002 startingPage "105" @default.
- W1972968002 abstract "Selective microbial colonisation of germ-free piglets is reported to result in expansion of immunoglobulin V(H)- and D(H)-segment usage from an initially limited repertoire. Here, the response of the palatine tonsil to microbial colonisation was compared in age-matched conventionally reared and germ-free piglets. At 3 and 5 days after birth an expansion in the B-cell follicle area was observed in the conventional, microbially colonised animals, which was not seen in the germ-free piglets. Consistent with this observation, sequencing of re-arranged heavy chain V-D-J units demonstrated accumulation of point mutations indicating somatic hypermutation in the conventional, microbially colonised piglets but not in the germ-free animals. However, V(H)- and D(H)-segment usage and CDR3 length did not differ between the groups. The results suggest that the follicle reaction observed occurs in response to microbial challenge, involves proliferation and somatic hypermutation of B-cells but does not expand repertoire or generate classical, isotype-switched memory B-cells. We suggest that microbial colonisation of neonatal piglets drives immunological competence in two stages: first, an antigen non-specific, follicular reaction which expands immunological compartments; and second, microbe driven changes in V-segment usage which expand immunological repertoire." @default.
- W1972968002 created "2016-06-24" @default.
- W1972968002 creator A5010673840 @default.
- W1972968002 creator A5027902867 @default.
- W1972968002 creator A5067031635 @default.
- W1972968002 creator A5076150347 @default.
- W1972968002 date "2007-07-01" @default.
- W1972968002 modified "2023-10-17" @default.
- W1972968002 title "Early, microbially driven follicular reactions in the neonatal piglet do not contribute to expansion of the immunoglobulin heavy chain V-D-J repertoire" @default.
- W1972968002 cites W1542142855 @default.
- W1972968002 cites W1568186032 @default.
- W1972968002 cites W1571661492 @default.
- W1972968002 cites W1601559584 @default.
- W1972968002 cites W1648713449 @default.
- W1972968002 cites W1661961827 @default.
- W1972968002 cites W1907111337 @default.
- W1972968002 cites W1972223008 @default.
- W1972968002 cites W1977162639 @default.
- W1972968002 cites W2008546779 @default.
- W1972968002 cites W2009473574 @default.
- W1972968002 cites W2017533703 @default.
- W1972968002 cites W2038706764 @default.
- W1972968002 cites W2074124566 @default.
- W1972968002 cites W2095384546 @default.
- W1972968002 cites W2125409137 @default.
- W1972968002 cites W2130929661 @default.
- W1972968002 cites W2578150941 @default.
- W1972968002 doi "https://doi.org/10.1016/j.vetimm.2007.04.018" @default.
- W1972968002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17560662" @default.
- W1972968002 hasPublicationYear "2007" @default.
- W1972968002 type Work @default.
- W1972968002 sameAs 1972968002 @default.
- W1972968002 citedByCount "4" @default.
- W1972968002 countsByYear W19729680022013 @default.
- W1972968002 countsByYear W19729680022014 @default.
- W1972968002 countsByYear W19729680022017 @default.
- W1972968002 crossrefType "journal-article" @default.
- W1972968002 hasAuthorship W1972968002A5010673840 @default.
- W1972968002 hasAuthorship W1972968002A5027902867 @default.
- W1972968002 hasAuthorship W1972968002A5067031635 @default.
- W1972968002 hasAuthorship W1972968002A5076150347 @default.
- W1972968002 hasConcept C104317684 @default.
- W1972968002 hasConcept C105878827 @default.
- W1972968002 hasConcept C121332964 @default.
- W1972968002 hasConcept C128526571 @default.
- W1972968002 hasConcept C134305767 @default.
- W1972968002 hasConcept C137756551 @default.
- W1972968002 hasConcept C159654299 @default.
- W1972968002 hasConcept C203014093 @default.
- W1972968002 hasConcept C24890656 @default.
- W1972968002 hasConcept C2776927270 @default.
- W1972968002 hasConcept C2777991845 @default.
- W1972968002 hasConcept C2778453870 @default.
- W1972968002 hasConcept C2778473898 @default.
- W1972968002 hasConcept C2910693471 @default.
- W1972968002 hasConcept C542903549 @default.
- W1972968002 hasConcept C54355233 @default.
- W1972968002 hasConcept C86803240 @default.
- W1972968002 hasConcept C89423630 @default.
- W1972968002 hasConceptScore W1972968002C104317684 @default.
- W1972968002 hasConceptScore W1972968002C105878827 @default.
- W1972968002 hasConceptScore W1972968002C121332964 @default.
- W1972968002 hasConceptScore W1972968002C128526571 @default.
- W1972968002 hasConceptScore W1972968002C134305767 @default.
- W1972968002 hasConceptScore W1972968002C137756551 @default.
- W1972968002 hasConceptScore W1972968002C159654299 @default.
- W1972968002 hasConceptScore W1972968002C203014093 @default.
- W1972968002 hasConceptScore W1972968002C24890656 @default.
- W1972968002 hasConceptScore W1972968002C2776927270 @default.
- W1972968002 hasConceptScore W1972968002C2777991845 @default.
- W1972968002 hasConceptScore W1972968002C2778453870 @default.
- W1972968002 hasConceptScore W1972968002C2778473898 @default.
- W1972968002 hasConceptScore W1972968002C2910693471 @default.
- W1972968002 hasConceptScore W1972968002C542903549 @default.
- W1972968002 hasConceptScore W1972968002C54355233 @default.
- W1972968002 hasConceptScore W1972968002C86803240 @default.
- W1972968002 hasConceptScore W1972968002C89423630 @default.
- W1972968002 hasIssue "1-2" @default.
- W1972968002 hasLocation W19729680021 @default.
- W1972968002 hasLocation W19729680022 @default.
- W1972968002 hasOpenAccess W1972968002 @default.
- W1972968002 hasPrimaryLocation W19729680021 @default.
- W1972968002 hasRelatedWork W1969447936 @default.
- W1972968002 hasRelatedWork W1972968002 @default.
- W1972968002 hasRelatedWork W2000107365 @default.
- W1972968002 hasRelatedWork W2105432925 @default.
- W1972968002 hasRelatedWork W2125544059 @default.
- W1972968002 hasRelatedWork W2126844156 @default.
- W1972968002 hasRelatedWork W2408172264 @default.
- W1972968002 hasRelatedWork W2610547910 @default.
- W1972968002 hasRelatedWork W2956156752 @default.
- W1972968002 hasRelatedWork W3205490018 @default.
- W1972968002 hasVolume "118" @default.
- W1972968002 isParatext "false" @default.
- W1972968002 isRetracted "false" @default.
- W1972968002 magId "1972968002" @default.
- W1972968002 workType "article" @default.