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• W1972979806 abstract "Motor neuron disease (MND) is a neurodegenerative condition long thought to be associated only with motor weakness. Recent work now shows that cognitive difficulties are present in up to half of the patients with this disorder. About 5–10% of patients with MND have a frank dementia that resembles frontotemporal lobar degeneration (FTLD). Imaging studies show quantitative abnormalities that resemble FTLD. Moreover, biochemical studies of ubiquinated histopathologic abnormalities in MND and FTLD reveal identical inclusions of TDP-43. These findings underline a fundamental link between MND and FTLD. This paper reviews this body of work." @default.
• W1972979806 created "2016-06-24" @default.
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• W1972979806 date "2007-12-05" @default.
• W1972979806 modified "2023-10-02" @default.
• W1972979806 title "Motor Neuron Disease and Frontotemporal Lobar Degeneration: A Tale of Two Disorders Linked To TDP-43" @default.
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• W1972979806 doi "https://doi.org/10.1159/000109762" @default.
• W1972979806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18097163" @default.
• W1972979806 hasPublicationYear "2007" @default.
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