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- W1972994868 abstract "Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia-reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury." @default.
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- W1972994868 date "2010-01-01" @default.
- W1972994868 modified "2023-10-04" @default.
- W1972994868 title "The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice" @default.
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- W1972994868 doi "https://doi.org/10.1254/jphs.09259sc" @default.
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