FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973009553> ?p ?o ?g. }

• W1973009553 endingPage "306" @default.
• W1973009553 startingPage "299" @default.
• W1973009553 abstract "It is generally assumed that squamous cell carcinoma develops in a stepwise manner from normal bronchial epithelium towards cancer by the accumulation of (epi)genetic alterations. Several mechanisms including mutations and homozygous deletions or hypermethylation of the p16INK4a promoter region can cause loss of p16 expression. Recent studies suggest overexpression of the polycomb-group gene BMI-1 might also down-regulate p16 expression. In this study, we analyzed the p16 expression in relation to the methylation status of the p16 promoter region of the p16INK4a gene and the expression of BMI-1 in bronchial squamous cell carcinomas (SCC) and its premalignant lesions. Nine (69%) SCC showed loss of p16 expression and 10 (77%) showed expression of BMI-1. Of four p16 positive samples two (50%) were BMI-1 positive, whereas among nine p16 negative samples, eight (89%) revealed BMI-1 staining. Four (44%) p16 negative samples were hypermethylated at the p16INK4a promoter region; the other p16 negative tumors that showed no hypermethylation revealed BMI-1 staining. Only two premalignant lesions showed absence of p16 expression, of which one (carcinoma in situ) was hypermethylated at the p16INK4a promoter region and the other (severe dysplasia) showed BMI-1 expression. In total, 11 precursor lesions (48%) revealed BMI-1 expression. In conclusion, the results of this study suggest that loss of p16 expression by promoter hypermethylation is inconsistently and occurs late in the carcinogenic process at the level of severe dysplasia. To what extent overexpression of the polycomb-group protein BMI-1 attributes to down regulating of p16 expression remains unclear." @default.
• W1973009553 created "2016-06-24" @default.
• W1973009553 creator A5004770669 @default.
• W1973009553 creator A5016904876 @default.
• W1973009553 creator A5042585460 @default.
• W1973009553 creator A5050340051 @default.
• W1973009553 creator A5056537893 @default.
• W1973009553 creator A5057336415 @default.
• W1973009553 creator A5069638685 @default.
• W1973009553 creator A5087604171 @default.
• W1973009553 creator A5091782541 @default.
• W1973009553 date "2005-06-01" @default.
• W1973009553 modified "2023-10-12" @default.
• W1973009553 title "Expression of the p16INK4a gene product, methylation of the p16INK4a promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung carcinoma and premalignant endobronchial lesions" @default.
• W1973009553 cites W1481473039 @default.
• W1973009553 cites W1919621203 @default.
• W1973009553 cites W1983348452 @default.
• W1973009553 cites W1984208534 @default.
• W1973009553 cites W1994465394 @default.
• W1973009553 cites W1995643652 @default.
• W1973009553 cites W1998218812 @default.
• W1973009553 cites W2004567377 @default.
• W1973009553 cites W2009669539 @default.
• W1973009553 cites W2016419622 @default.
• W1973009553 cites W2022557585 @default.
• W1973009553 cites W2034269086 @default.
• W1973009553 cites W2034294816 @default.
• W1973009553 cites W2058052840 @default.
• W1973009553 cites W2059972525 @default.
• W1973009553 cites W2062206970 @default.
• W1973009553 cites W2066848701 @default.
• W1973009553 cites W2070207712 @default.
• W1973009553 cites W2081428426 @default.
• W1973009553 cites W2097166664 @default.
• W1973009553 cites W2105298978 @default.
• W1973009553 cites W2110511887 @default.
• W1973009553 cites W2145603992 @default.
• W1973009553 cites W2146236962 @default.
• W1973009553 cites W2149571025 @default.
• W1973009553 cites W2151598146 @default.
• W1973009553 cites W2154891376 @default.
• W1973009553 cites W2159108509 @default.
• W1973009553 cites W2160059440 @default.
• W1973009553 doi "https://doi.org/10.1016/j.lungcan.2004.11.026" @default.
• W1973009553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15892997" @default.
• W1973009553 hasPublicationYear "2005" @default.
• W1973009553 type Work @default.
• W1973009553 sameAs 1973009553 @default.
• W1973009553 citedByCount "58" @default.
• W1973009553 countsByYear W19730095532012 @default.
• W1973009553 countsByYear W19730095532013 @default.
• W1973009553 countsByYear W19730095532014 @default.
• W1973009553 countsByYear W19730095532015 @default.
• W1973009553 countsByYear W19730095532016 @default.
• W1973009553 countsByYear W19730095532017 @default.
• W1973009553 countsByYear W19730095532021 @default.
• W1973009553 crossrefType "journal-article" @default.
• W1973009553 hasAuthorship W1973009553A5004770669 @default.
• W1973009553 hasAuthorship W1973009553A5016904876 @default.
• W1973009553 hasAuthorship W1973009553A5042585460 @default.
• W1973009553 hasAuthorship W1973009553A5050340051 @default.
• W1973009553 hasAuthorship W1973009553A5056537893 @default.
• W1973009553 hasAuthorship W1973009553A5057336415 @default.
• W1973009553 hasAuthorship W1973009553A5069638685 @default.
• W1973009553 hasAuthorship W1973009553A5087604171 @default.
• W1973009553 hasAuthorship W1973009553A5091782541 @default.
• W1973009553 hasConcept C101762097 @default.
• W1973009553 hasConcept C104317684 @default.
• W1973009553 hasConcept C121608353 @default.
• W1973009553 hasConcept C126322002 @default.
• W1973009553 hasConcept C142724271 @default.
• W1973009553 hasConcept C150194340 @default.
• W1973009553 hasConcept C190727270 @default.
• W1973009553 hasConcept C204232928 @default.
• W1973009553 hasConcept C2775894508 @default.
• W1973009553 hasConcept C2776256026 @default.
• W1973009553 hasConcept C2777546739 @default.
• W1973009553 hasConcept C33288867 @default.
• W1973009553 hasConcept C502942594 @default.
• W1973009553 hasConcept C54355233 @default.
• W1973009553 hasConcept C71924100 @default.
• W1973009553 hasConcept C86803240 @default.
• W1973009553 hasConceptScore W1973009553C101762097 @default.
• W1973009553 hasConceptScore W1973009553C104317684 @default.
• W1973009553 hasConceptScore W1973009553C121608353 @default.
• W1973009553 hasConceptScore W1973009553C126322002 @default.
• W1973009553 hasConceptScore W1973009553C142724271 @default.
• W1973009553 hasConceptScore W1973009553C150194340 @default.
• W1973009553 hasConceptScore W1973009553C190727270 @default.
• W1973009553 hasConceptScore W1973009553C204232928 @default.
• W1973009553 hasConceptScore W1973009553C2775894508 @default.
• W1973009553 hasConceptScore W1973009553C2776256026 @default.
• W1973009553 hasConceptScore W1973009553C2777546739 @default.
• W1973009553 hasConceptScore W1973009553C33288867 @default.
• W1973009553 hasConceptScore W1973009553C502942594 @default.
• W1973009553 hasConceptScore W1973009553C54355233 @default.
• W1973009553 hasConceptScore W1973009553C71924100 @default.
• W1973009553 hasConceptScore W1973009553C86803240 @default.

• next