FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973011197> ?p ?o ?g. }

• W1973011197 endingPage "268" @default.
• W1973011197 startingPage "261" @default.
• W1973011197 abstract "XB51 (derived from X11-like binding protein of clone number 51) was isolated by yeast two-hybrid cDNA screening using the N-terminal domain of X11L (X11-like protein) as a bait. X11L is a neuron-specific adaptor protein that is known to down-regulate APP (beta-amyloid precursor protein) metabolism by associating with the cytoplasmic domain of APP, but the detailed mechanisms are still unknown. Thus the X11L-associated protein XB51 is believed to regulate APP metabolism by modifying X11L function through its interaction with X11L. Here we report that the hXB51 (human XB51 ) gene can yield two transcripts, one with exon 9 spliced out (resulting in the hXB51beta isoform) and the other containing exon 9 (yielding the hXB51alpha isoform). hXB51alpha binds to X11L to form a tripartite complex composed of hXB51alpha, X11L and APP. Complex-formation results in blocking X11L's suppression of Abeta (beta-amyloid) generation from APP. hXB51beta associates with X11L and inhibits its interaction with APP. However, hXB51beta suppresses Abeta generation and secretion in an X11L-independent manner. Thus the hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner. These observations advance our understanding of the molecular mechanisms regulating intracellular Abeta production and the pathogenesis of Alzheimer's disease." @default.
• W1973011197 created "2016-06-24" @default.
• W1973011197 creator A5016501068 @default.
• W1973011197 creator A5033313384 @default.
• W1973011197 creator A5053314310 @default.
• W1973011197 creator A5065167441 @default.
• W1973011197 creator A5083750738 @default.
• W1973011197 date "2003-08-15" @default.
• W1973011197 modified "2023-10-02" @default.
• W1973011197 title "XB51 isoforms mediate Alzheimer's β-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms" @default.
• W1973011197 cites W1502820594 @default.
• W1973011197 cites W1757544724 @default.
• W1973011197 cites W1821771945 @default.
• W1973011197 cites W1943916690 @default.
• W1973011197 cites W1976967535 @default.
• W1973011197 cites W1981440257 @default.
• W1973011197 cites W1983996266 @default.
• W1973011197 cites W1994346902 @default.
• W1973011197 cites W1999466646 @default.
• W1973011197 cites W2002025388 @default.
• W1973011197 cites W2002276178 @default.
• W1973011197 cites W2004782459 @default.
• W1973011197 cites W2017399951 @default.
• W1973011197 cites W2031565865 @default.
• W1973011197 cites W2041076714 @default.
• W1973011197 cites W2053097410 @default.
• W1973011197 cites W2057840062 @default.
• W1973011197 cites W2075202596 @default.
• W1973011197 cites W2075385027 @default.
• W1973011197 cites W2081458574 @default.
• W1973011197 cites W2087496042 @default.
• W1973011197 cites W2088440342 @default.
• W1973011197 cites W2115704372 @default.
• W1973011197 cites W2166260474 @default.
• W1973011197 cites W2168029064 @default.
• W1973011197 cites W2169152986 @default.
• W1973011197 cites W39375236 @default.
• W1973011197 doi "https://doi.org/10.1042/bj20030489" @default.
• W1973011197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1223589" @default.
• W1973011197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12780348" @default.
• W1973011197 hasPublicationYear "2003" @default.
• W1973011197 type Work @default.
• W1973011197 sameAs 1973011197 @default.
• W1973011197 citedByCount "19" @default.
• W1973011197 countsByYear W19730111972013 @default.
• W1973011197 countsByYear W19730111972014 @default.
• W1973011197 countsByYear W19730111972015 @default.
• W1973011197 countsByYear W19730111972016 @default.
• W1973011197 countsByYear W19730111972019 @default.
• W1973011197 countsByYear W19730111972021 @default.
• W1973011197 crossrefType "journal-article" @default.
• W1973011197 hasAuthorship W1973011197A5016501068 @default.
• W1973011197 hasAuthorship W1973011197A5033313384 @default.
• W1973011197 hasAuthorship W1973011197A5053314310 @default.
• W1973011197 hasAuthorship W1973011197A5065167441 @default.
• W1973011197 hasAuthorship W1973011197A5083750738 @default.
• W1973011197 hasBestOaLocation W19730111972 @default.
• W1973011197 hasConcept C104317684 @default.
• W1973011197 hasConcept C126322002 @default.
• W1973011197 hasConcept C135979968 @default.
• W1973011197 hasConcept C177907266 @default.
• W1973011197 hasConcept C180081513 @default.
• W1973011197 hasConcept C183786373 @default.
• W1973011197 hasConcept C194583182 @default.
• W1973011197 hasConcept C2776156579 @default.
• W1973011197 hasConcept C2777633098 @default.
• W1973011197 hasConcept C2779134260 @default.
• W1973011197 hasConcept C2779281246 @default.
• W1973011197 hasConcept C31705614 @default.
• W1973011197 hasConcept C36103677 @default.
• W1973011197 hasConcept C36823959 @default.
• W1973011197 hasConcept C41007966 @default.
• W1973011197 hasConcept C502032728 @default.
• W1973011197 hasConcept C53345823 @default.
• W1973011197 hasConcept C55493867 @default.
• W1973011197 hasConcept C59822182 @default.
• W1973011197 hasConcept C62478195 @default.
• W1973011197 hasConcept C71924100 @default.
• W1973011197 hasConcept C79879829 @default.
• W1973011197 hasConcept C86803240 @default.
• W1973011197 hasConcept C95444343 @default.
• W1973011197 hasConceptScore W1973011197C104317684 @default.
• W1973011197 hasConceptScore W1973011197C126322002 @default.
• W1973011197 hasConceptScore W1973011197C135979968 @default.
• W1973011197 hasConceptScore W1973011197C177907266 @default.
• W1973011197 hasConceptScore W1973011197C180081513 @default.
• W1973011197 hasConceptScore W1973011197C183786373 @default.
• W1973011197 hasConceptScore W1973011197C194583182 @default.
• W1973011197 hasConceptScore W1973011197C2776156579 @default.
• W1973011197 hasConceptScore W1973011197C2777633098 @default.
• W1973011197 hasConceptScore W1973011197C2779134260 @default.
• W1973011197 hasConceptScore W1973011197C2779281246 @default.
• W1973011197 hasConceptScore W1973011197C31705614 @default.
• W1973011197 hasConceptScore W1973011197C36103677 @default.
• W1973011197 hasConceptScore W1973011197C36823959 @default.
• W1973011197 hasConceptScore W1973011197C41007966 @default.
• W1973011197 hasConceptScore W1973011197C502032728 @default.
• W1973011197 hasConceptScore W1973011197C53345823 @default.

• next