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- W1973014582 abstract "Previous studies in mice and humans have shown that the first IgA+ and IgG+ B cells appearing during ontogeny also bear IgM on the surface. The acquisition of IgD seems to occur at a later stage in differentiation. In this study we have combined autoradiography with two-color immunofluorescence to directly detect human B cells expressing three surface isotypes. We report that the vast majority of IgA+ cells in the neonate also bear IgM and IgD; the same holds true for IgG+ cells. This phenotype is peculiar of newborns, while in the adult the majority of IgA+ and IgG+ cells are single. We discuss the genetic implications of such a finding for heavy chain switching." @default.
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- W1973014582 date "1981-08-01" @default.
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- W1973014582 title "Expression of Three Immunoglobulin Isotypes by Individual B Cells During Development: Implications for Heavy Chain Switching*" @default.
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- W1973014582 doi "https://doi.org/10.1111/j.1600-0897.1981.tb00028.x" @default.
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