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- W1973014722 abstract "A novel chemo-enzymatic synthesis of (S)-rivastigmine using ketoreductases with NADH/NADPH as the proton donor has been demonstrated. An exclusive enzymatic process has been developed by exploring the possible ketoreductases by screening to identify enzymes useful for the preparation of the (S)-isomer intermediate, and scaling up of the enzymatic process for the production of an adequate, enantiomerically pure precursor of rivastigmine and for the total synthesis of (S)-rivastigmine." @default.
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- W1973014722 date "2013-04-01" @default.
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- W1973014722 title "Asymmetric synthesis of an enantiomerically pure rivastigmine intermediate using ketoreductase" @default.
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- W1973014722 doi "https://doi.org/10.1016/j.tetasy.2013.01.023" @default.
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