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- W1973018894 abstract "Abstract Higher-risk myelodysplastic syndromes (MDS) are defined by patients who fall into higher-risk group categories in the original or revised International Prognostic Scoring System. Survival for these patients is dismal, and treatment should be initiated rapidly. Standard therapies include the hypomethylating agents azacitidine and decitabine, which should be administered for a minimum of 6 cycles, and continued for as long as a patient is responding. Once a drug fails in one of these patients, further treatment options are limited, median survival is <6 months, and consideration should be given to clinical trials. Higher-risk eligible patients should be offered consultation to discuss hematopoietic stem cell transplantation close to the time of diagnosis, depending on patient goals of therapy, with consideration given to proceeding to transplantation soon after an optimal donor is located. In the interim period before transplantation, hypomethylating agent therapy, induction chemotherapy, or enrollment in a clinical trial should be considered to prevent disease progression, although the optimal pretransplantation therapy is unknown." @default.
- W1973018894 created "2016-06-24" @default.
- W1973018894 creator A5029278364 @default.
- W1973018894 creator A5055740968 @default.
- W1973018894 date "2014-02-06" @default.
- W1973018894 modified "2023-10-14" @default.
- W1973018894 title "How we treat higher-risk myelodysplastic syndromes" @default.
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