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• W1973019528 abstract "Angiotensin II (Ang II), a major regulator of cardiovascular function and body fluid homeostasis, mediates its biological actions via two subtypes of G protein-coupled receptors, termed AT1 and AT2. The primary goal of this study was to raise monoclonal anti-peptide antibodies specific to angiotensin AT1- and AT2-receptor subtypes and to Ang II itself and using these monoclonal antibodies to determine the intraadrenal localization of AT1 and AT2 receptors and Ang II in male adult rats. Immunocytochemistry unambiguously demonstrates a regional colocalization of Ang II and angiotensin II receptors in the adrenal gland. The novel antibodies localized Ang II and the AT1 receptors to the zona glomerulosa of the cortex and to the medulla whereas AT2 receptors were limited to the medulla. The specificity of immunostaining was documented by pre-adsorption of the antibody with the immunogenic peptide. Our data underscore that AT1 appears to mediate most of the physiological actions of Ang II in adrenal. Western blot analysis of rat adrenal protein extracts using AT1 antibody showed a predominant 73-kDa band and a weaker 97-kDa immunoreactive band corresponding to glycosylated forms of the AT1 receptor. Immunostaining with anti-AT2 yielded one major immunoreactive band of 73-kDa size and one additional fainter band of 120 kDa. These antibodies may prove of value in unraveling the subcellular localization and intracellular effector pathways of AT1 and AT2." @default.
• W1973019528 created "2016-06-24" @default.
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• W1973019528 date "2001-09-01" @default.
• W1973019528 modified "2023-09-23" @default.
• W1973019528 title "Immunocytochemical localization of angiotensin II receptor subtypes and angiotensin II with monoclonal antibodies in the rat adrenal gland" @default.
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• W1973019528 doi "https://doi.org/10.1016/s0167-0115(01)00278-6" @default.
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