FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973033666> ?p ?o ?g. }

• W1973033666 endingPage "1592" @default.
• W1973033666 startingPage "1576" @default.
• W1973033666 abstract "The disulfide-reduced form of bovine ribonuclease A, with the Cys thiols irreversibly blocked, was characterized by small-angle x-ray scattering. To help resolve the conflicting results and interpretations from previous studies of this model unfolded protein, we measured scattering profiles using a range of solution conditions and compared them with the profiles predicted by a computational model for a random-coil polypeptide. Analysis of the simulated and experimental profiles reveals that scattering intensities at intermediate angles, corresponding to interatomic distances in the range of 5-20 A, are particularly sensitive to changes in solvation and can be used to assess the internal scaling behavior of the polypeptide chain, expressed as a mass fractal dimension, D(m). This region of the scattering curve is also much less sensitive to experimental artifacts than is the very small angle regime (the Guinier region) that has been more typically used to characterize unfolded proteins. The experimental small-angle x-ray scattering profiles closely matched those predicted by the computational model assuming relatively small solvation energies. The scaling behavior of the polypeptide approaches that of a well-solvated polymer under conditions where it has a large net charge and at high urea concentrations. At lower urea concentrations and neutral pH, the behavior of the chain approaches that expected for theta-conditions, where the effects of slightly unfavorable interactions with solvent balance those of excluded volume, leading to scaling behavior comparable to that of an idealized random walk chain. Though detectable, the shift toward more compact conformations at lower urea concentrations does not correspond to a transition to a globule state and is associated with little or no reduction in conformational entropy. This type of collapse, therefore, is unlikely to greatly reduce the conformational search for the native state." @default.
• W1973033666 created "2016-06-24" @default.
• W1973033666 creator A5025867911 @default.
• W1973033666 creator A5032111372 @default.
• W1973033666 creator A5065418938 @default.
• W1973033666 date "2008-04-01" @default.
• W1973033666 modified "2023-10-14" @default.
• W1973033666 title "Small-Angle X-ray Scattering of Reduced Ribonuclease A: Effects of Solution Conditions and Comparisons with a Computational Model of Unfolded Proteins" @default.
• W1973033666 cites W1515255916 @default.
• W1973033666 cites W1517145530 @default.
• W1973033666 cites W1576271719 @default.
• W1973033666 cites W1580614613 @default.
• W1973033666 cites W1965834031 @default.
• W1973033666 cites W1970434234 @default.
• W1973033666 cites W1974877835 @default.
• W1973033666 cites W1976301147 @default.
• W1973033666 cites W1979537410 @default.
• W1973033666 cites W1982006129 @default.
• W1973033666 cites W1982383324 @default.
• W1973033666 cites W1984048831 @default.
• W1973033666 cites W1985204165 @default.
• W1973033666 cites W1985324105 @default.
• W1973033666 cites W1990279360 @default.
• W1973033666 cites W1991498388 @default.
• W1973033666 cites W1993358245 @default.
• W1973033666 cites W2004360551 @default.
• W1973033666 cites W2006192061 @default.
• W1973033666 cites W2015737242 @default.
• W1973033666 cites W2020343270 @default.
• W1973033666 cites W2025264553 @default.
• W1973033666 cites W2026861087 @default.
• W1973033666 cites W2027384625 @default.
• W1973033666 cites W2031091369 @default.
• W1973033666 cites W2033210496 @default.
• W1973033666 cites W2035584307 @default.
• W1973033666 cites W2036712659 @default.
• W1973033666 cites W2043297959 @default.
• W1973033666 cites W2043750499 @default.
• W1973033666 cites W2045777307 @default.
• W1973033666 cites W2046033652 @default.
• W1973033666 cites W2047138766 @default.
• W1973033666 cites W2048354558 @default.
• W1973033666 cites W2050504425 @default.
• W1973033666 cites W2051039246 @default.
• W1973033666 cites W2052933818 @default.
• W1973033666 cites W2053591536 @default.
• W1973033666 cites W2055070122 @default.
• W1973033666 cites W2058238447 @default.
• W1973033666 cites W2060002111 @default.
• W1973033666 cites W2064342255 @default.
• W1973033666 cites W2066041565 @default.
• W1973033666 cites W2066088601 @default.
• W1973033666 cites W2066122019 @default.
• W1973033666 cites W2067798279 @default.
• W1973033666 cites W2070569568 @default.
• W1973033666 cites W2072654958 @default.
• W1973033666 cites W2073745520 @default.
• W1973033666 cites W2080132141 @default.
• W1973033666 cites W2080382112 @default.
• W1973033666 cites W2083255041 @default.
• W1973033666 cites W2088397672 @default.
• W1973033666 cites W2089618587 @default.
• W1973033666 cites W2092756551 @default.
• W1973033666 cites W2095494916 @default.
• W1973033666 cites W2096409300 @default.
• W1973033666 cites W2103208396 @default.
• W1973033666 cites W2105418804 @default.
• W1973033666 cites W2110113231 @default.
• W1973033666 cites W2114304598 @default.
• W1973033666 cites W2117747873 @default.
• W1973033666 cites W2119693327 @default.
• W1973033666 cites W2121167852 @default.
• W1973033666 cites W2121479624 @default.
• W1973033666 cites W2131350374 @default.
• W1973033666 cites W2140551148 @default.
• W1973033666 cites W2141660716 @default.
• W1973033666 cites W2162651138 @default.
• W1973033666 cites W2180204534 @default.
• W1973033666 cites W2312213132 @default.
• W1973033666 cites W2334086406 @default.
• W1973033666 cites W2607732975 @default.
• W1973033666 cites W3103544692 @default.
• W1973033666 cites W4211239749 @default.
• W1973033666 cites W4248782386 @default.
• W1973033666 doi "https://doi.org/10.1016/j.jmb.2008.02.009" @default.
• W1973033666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2651769" @default.
• W1973033666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18329044" @default.
• W1973033666 hasPublicationYear "2008" @default.
• W1973033666 type Work @default.
• W1973033666 sameAs 1973033666 @default.
• W1973033666 citedByCount "37" @default.
• W1973033666 countsByYear W19730336662012 @default.
• W1973033666 countsByYear W19730336662013 @default.
• W1973033666 countsByYear W19730336662014 @default.
• W1973033666 countsByYear W19730336662015 @default.
• W1973033666 countsByYear W19730336662016 @default.
• W1973033666 countsByYear W19730336662017 @default.
• W1973033666 countsByYear W19730336662018 @default.

• next