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• W1973039447 endingPage "e5036" @default.
• W1973039447 startingPage "e5036" @default.
• W1973039447 abstract "Synonymous codon usage and variations in the level of isoaccepting tRNAs exert a powerful selective force on translation fidelity. We have developed an algorithm to evaluate the relative rate of translation which allows large-scale comparisons of the non-uniform translation rate on the protein biogenesis. Using the complete genomes of Escherichia coli and Bacillus subtilis we show that stretches of codons pairing to minor tRNAs form putative sites to locally attenuate translation; thereby the tendency is to cluster in near proximity whereas long contiguous stretches of slow-translating triplets are avoided. The presence of slow-translating segments positively correlates with the protein length irrespective of the protein abundance. The slow-translating clusters are predominantly located down-stream of the domain boundaries presumably to fine-tune translational accuracy with the folding fidelity of multidomain proteins. Translation attenuation patterns at highly structurally and functionally conserved domains are preserved across the species suggesting a concerted selective pressure on the codon selection and species-specific tRNA abundance in these regions." @default.
• W1973039447 created "2016-06-24" @default.
• W1973039447 creator A5031275669 @default.
• W1973039447 creator A5051991397 @default.
• W1973039447 date "2009-04-03" @default.
• W1973039447 modified "2023-10-03" @default.
• W1973039447 title "Generic Algorithm to Predict the Speed of Translational Elongation: Implications for Protein Biogenesis" @default.
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• W1973039447 doi "https://doi.org/10.1371/journal.pone.0005036" @default.
• W1973039447 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2661179" @default.
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• W1973039447 hasPublicationYear "2009" @default.
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