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• W1973053134 abstract "Prostaglandin E2 (PGE2) was administered orally in a dose of 1 mg to healthy males (n = 20) and females (n = 10). Blood levels of 15-keto-13, 14-dihydroprostaglandin F2α (PGF2α-M) and 15-keto-13, 14- dihydroprostaglandin E2 (PGE2-M), determined as the rearrangement product 11-deoxy-15-keto-13,14-dihydro-11β,16-cycloprostaglandin E2 (PGE2-cyclo-M), were measured. The levels of the two PG metabolites increased already 10 minutes after ingestion of the tablet and the mean peak value for PGE2-cyclo-M in the men was 4.64 nmol/l which was reached 50 minutes after PGE2 administration. The mean peak value in women was 4.99 nmol/l which was obtained after 30 minutes. The increase in PGE2-cyclo-M concentration was significantly faster (p < 0.05) in women than in the men. The mean plasma concentration of PGF2α in males was 0.20 nmol/l prior to treatment and rose after PGE2 ingestion to a mean peak level of 0.84 nmol/l after 70 minutes. The corresponding values for the females were 0.18 nmol/l and 0.88 nmol/l 50 minutes into treatment. When the data from both sexes were amalgamated PGE2-cyclo-M peak levels were reached significantly (p = 0.004) sooner than the PGF2α-M peak. The two PG metabolites returned to baseline levels in 70% of the individuals after 240 minutes. The increase in PGF2α-M concentration following oral administration of PGE2 indicates that part of the PGE2 was reduced to PGF2α. The fact that no difference was observed in the kinetics of the PGE2-cyclo-M and PGF2α-M in blood following PGE2 administration before and after one week of naproxen treatment supports this assumption. An increase in PGE2-cyclo-M blood levels following intravenous injection of PGF2α in two women indicated that PGF2α could be oxidized to PGE2. However, it cannot be excluded that PGE2 or PGF2α administration also might affect endogenous prostaglandin biosynthesis." @default.
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• W1973053134 date "1989-09-01" @default.
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• W1973053134 title "15-Keto-13, 14-dihydroprostaglandin E2-and F2α-metabolite levels in blood from men and women given prostaglandin E2 orally" @default.
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• W1973053134 doi "https://doi.org/10.1016/0952-3278(89)90081-1" @default.
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