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- W1973061199 abstract "Cells with greater membrane microviscosities are reportedly less sensitive to being killed by mild hyperthermia. To further study this phenomenon, membrane microviscosity of ascites P-388 tumor cells was increased by adding cholesteryl hemisuccinate (CHS). Unexpectedly, when modified cells were heated for 60 min at 43 degrees C in vitro and analyzed in vivo in CDF1 mice they showed an increased thermal sensitivity. Similar increases in cell membrane microviscosity were obtained with V-79 cells. However, after heat treatment no differences in survival in vitro were noted between modified and unmodified cells. Treatment with CHS alone results in a substantial increase in P-388 cells, which take up trypan blue, but not in V-79 cells. When these 'dead' cells are accounted for, the difference in killing between control and CHS-modified P-388 cells is no longer seen. When considered in this light, both P-388 and V-79 cells are similar in their response to heat, which is not influenced by CHS per se." @default.
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- W1973061199 date "1983-09-01" @default.
- W1973061199 modified "2023-09-26" @default.
- W1973061199 title "The effects of membrane modification and hyperthermia on the survival of P-388 and V-79 cells" @default.
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- W1973061199 doi "https://doi.org/10.1016/0277-5379(83)90202-x" @default.
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