FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973061822> ?p ?o ?g. }

• W1973061822 endingPage "113" @default.
• W1973061822 startingPage "105" @default.
• W1973061822 abstract "Babies of obese women are often large at birth, which is associated with perinatal complications and metabolic syndrome later in life. The mechanisms linking maternal obesity to fetal overgrowth are largely unknown. We tested the hypothesis that placental insulin/IGF-I and mammalian target of rapamycin (mTOR) signaling is activated and amino acid transporter activity is increased in large babies of obese women. Pregnant women were recruited prospectively for collection of placental tissue at a university hospital and academic biomedical center. Twenty-three Swedish pregnant women with first trimester body mass index ranging from 18.5 to 44.9 kg/m2 and with uncomplicated pregnancies participated in the study. There were no interventions. We determined the phosphorylation of key signaling molecules (including Akt, IRS-1, S6K1, 4EBP-1, RPS6, and AMPK) in the placental insulin/IGF-I, AMPK, and mTOR signaling pathways. The activity and protein expression of the amino acid transporter systems A and L were measured in syncytiotrophoblast microvillous plasma membranes. Birth weights (range, 3025–4235 g) were positively correlated to maternal body mass index (P < 0.05). The activity of placental insulin/IGF-I and mTOR signaling was positively correlated (P < 0.001), whereas AMPK phosphorylation was inversely (P < 0.05) correlated to birth weight. Microvillous plasma membrane system A, but not system L, activity and protein expression of the system A isoform SNAT2 were positively correlated to birth weight (P < 0.001). Up-regulation of specific placental amino acid transporter isoforms may contribute to fetal overgrowth in maternal obesity. This effect may be mediated by activation of insulin/IGF-I and mTOR signaling pathways, which are positive regulators of placental amino acid transporters." @default.
• W1973061822 created "2016-06-24" @default.
• W1973061822 creator A5002996262 @default.
• W1973061822 creator A5012095763 @default.
• W1973061822 creator A5019216770 @default.
• W1973061822 creator A5024848351 @default.
• W1973061822 creator A5040383117 @default.
• W1973061822 creator A5043780732 @default.
• W1973061822 creator A5068691304 @default.
• W1973061822 creator A5084143859 @default.
• W1973061822 date "2013-01-01" @default.
• W1973061822 modified "2023-10-14" @default.
• W1973061822 title "Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies" @default.
• W1973061822 cites W1966172370 @default.
• W1973061822 cites W1979943253 @default.
• W1973061822 cites W1982342883 @default.
• W1973061822 cites W1986520434 @default.
• W1973061822 cites W1990834741 @default.
• W1973061822 cites W2006601239 @default.
• W1973061822 cites W2007042696 @default.
• W1973061822 cites W2013435469 @default.
• W1973061822 cites W2018765008 @default.
• W1973061822 cites W2031987784 @default.
• W1973061822 cites W2032226016 @default.
• W1973061822 cites W2037594642 @default.
• W1973061822 cites W2037606593 @default.
• W1973061822 cites W2040336914 @default.
• W1973061822 cites W2041519751 @default.
• W1973061822 cites W2055318064 @default.
• W1973061822 cites W2066227159 @default.
• W1973061822 cites W2077283526 @default.
• W1973061822 cites W2083766584 @default.
• W1973061822 cites W2099544753 @default.
• W1973061822 cites W2103467021 @default.
• W1973061822 cites W2105807298 @default.
• W1973061822 cites W2107463683 @default.
• W1973061822 cites W2110873096 @default.
• W1973061822 cites W2111882545 @default.
• W1973061822 cites W2112259927 @default.
• W1973061822 cites W2113432131 @default.
• W1973061822 cites W2121291228 @default.
• W1973061822 cites W2122274477 @default.
• W1973061822 cites W2127019896 @default.
• W1973061822 cites W2131629100 @default.
• W1973061822 cites W2135209333 @default.
• W1973061822 cites W2140865853 @default.
• W1973061822 cites W2143142730 @default.
• W1973061822 cites W2155091020 @default.
• W1973061822 cites W2157695581 @default.
• W1973061822 cites W2160209138 @default.
• W1973061822 cites W2160827694 @default.
• W1973061822 cites W2169869070 @default.
• W1973061822 cites W2217605000 @default.
• W1973061822 cites W2409262434 @default.
• W1973061822 cites W2623967298 @default.
• W1973061822 doi "https://doi.org/10.1210/jc.2012-2667" @default.
• W1973061822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3537112" @default.
• W1973061822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23150676" @default.
• W1973061822 hasPublicationYear "2013" @default.
• W1973061822 type Work @default.
• W1973061822 sameAs 1973061822 @default.
• W1973061822 citedByCount "230" @default.
• W1973061822 countsByYear W19730618222013 @default.
• W1973061822 countsByYear W19730618222014 @default.
• W1973061822 countsByYear W19730618222015 @default.
• W1973061822 countsByYear W19730618222016 @default.
• W1973061822 countsByYear W19730618222017 @default.
• W1973061822 countsByYear W19730618222018 @default.
• W1973061822 countsByYear W19730618222019 @default.
• W1973061822 countsByYear W19730618222020 @default.
• W1973061822 countsByYear W19730618222021 @default.
• W1973061822 countsByYear W19730618222022 @default.
• W1973061822 countsByYear W19730618222023 @default.
• W1973061822 crossrefType "journal-article" @default.
• W1973061822 hasAuthorship W1973061822A5002996262 @default.
• W1973061822 hasAuthorship W1973061822A5012095763 @default.
• W1973061822 hasAuthorship W1973061822A5019216770 @default.
• W1973061822 hasAuthorship W1973061822A5024848351 @default.
• W1973061822 hasAuthorship W1973061822A5040383117 @default.
• W1973061822 hasAuthorship W1973061822A5043780732 @default.
• W1973061822 hasAuthorship W1973061822A5068691304 @default.
• W1973061822 hasAuthorship W1973061822A5084143859 @default.
• W1973061822 hasBestOaLocation W19730618221 @default.
• W1973061822 hasConcept C11960822 @default.
• W1973061822 hasConcept C126322002 @default.
• W1973061822 hasConcept C134018914 @default.
• W1973061822 hasConcept C161573976 @default.
• W1973061822 hasConcept C172680121 @default.
• W1973061822 hasConcept C2776953305 @default.
• W1973061822 hasConcept C2779234561 @default.
• W1973061822 hasConcept C2779306644 @default.
• W1973061822 hasConcept C2779315647 @default.
• W1973061822 hasConcept C2780124434 @default.
• W1973061822 hasConcept C54355233 @default.
• W1973061822 hasConcept C55493867 @default.
• W1973061822 hasConcept C62478195 @default.
• W1973061822 hasConcept C71924100 @default.
• W1973061822 hasConcept C75217442 @default.

• next