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• W1973065042 abstract "We analyze human-specific KEGG pathways trying to understand the functional role of intrinsic disorder in proteins. Pathways provide a comprehensive picture of biological processes and allow better understanding of a protein's function within the specific context of its surroundings. Our study pinpoints a few specific pathways significantly enriched in disorder-containing proteins and identifies the role of these proteins within the framework of pathway relationships. Three major categories of relations are shown to be significantly enriched in disordered proteins: gene expression, protein binding and to a lesser degree, protein phosphorylation. Finally we find that relations involving protein activation and to some extent inhibition are characterized by low disorder content." @default.
• W1973065042 created "2016-06-24" @default.
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• W1973065042 date "2012-01-01" @default.
• W1973065042 modified "2023-09-26" @default.
• W1973065042 title "Intrinsic protein disorder in human pathways" @default.
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• W1973065042 doi "https://doi.org/10.1039/c1mb05274h" @default.
• W1973065042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3584708" @default.
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• W1973065042 hasPublicationYear "2012" @default.
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