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• W1973072622 startingPage "7549" @default.
• W1973072622 abstract "We report on selectivity profiling of 1 in a panel of 20 protein kinases and molecular modeling indicating 1 to be highly active and selective for VEGF-R2/3. Sequence alignment analysis and detailed insights into the ATP binding pockets of targeted protein kinases from the panel result in a unique structural architecture of VEGF-R2 mainly caused by the hydrophobic pocket I, determining the molecular basis for activity and selectivity of 1." @default.
• W1973072622 created "2016-06-24" @default.
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• W1973072622 date "2006-11-14" @default.
• W1973072622 modified "2023-09-27" @default.
• W1973072622 title "Profile and Molecular Modeling of 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1<i>H</i>-pyrrole-2,5dione (<b>1</b>) as a Highly Selective VEGF-R2/3 Inhibitor" @default.
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• W1973072622 doi "https://doi.org/10.1021/jm0609871" @default.
• W1973072622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17149885" @default.
• W1973072622 hasPublicationYear "2006" @default.
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