FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973076433> ?p ?o ?g. }

• W1973076433 endingPage "296" @default.
• W1973076433 startingPage "285" @default.
• W1973076433 abstract "In patients with systemic lupus erythematosus (SLE), frequency of the T cells positive for HLA-DP, one of the major histocompatibility complex (MHC) class II molecules, was markedly increased in peripheral blood lymphocytes (PBL), in association with an increase in the amount of specific cytoplasmic transcript of the HLA-DP gene segment. Cell cycle analysis showed that HLA-DP is an early activation marker of T cells and that the high ratios of HLA-DP+ T cells from SLE patients are associated with high frequency of T cells at early activation phases, mainly of G1A. Initial high ratios of HLA-DP+ T cells decreased to a great extent during 4 days of in vitro culture, in the absence of mitogens. This event was associated with decreases in the amount of HLA-DP transcript and the disappearance of activated T cells. Studies on the interleukin 2 (IL-2) production of T cells from patients with SLE demonstrated that while the PBL rich in HLA-DP+ T cells show a markedly low production of IL-2, preculture of these PBL restores the ability to produce IL-2. Thus, it appears that the T cells in patients with SLE are essentially intact with regard to the capacity to produce IL-2 and that T cell activation events continuously occurring in SLE patients are related to a deficiency in IL-2 production. The possible underlying mechanisms are discussed." @default.
• W1973076433 created "2016-06-24" @default.
• W1973076433 creator A5003122942 @default.
• W1973076433 creator A5018977107 @default.
• W1973076433 creator A5050835989 @default.
• W1973076433 creator A5054986463 @default.
• W1973076433 creator A5061947125 @default.
• W1973076433 creator A5070334003 @default.
• W1973076433 creator A5075235588 @default.
• W1973076433 creator A5075427398 @default.
• W1973076433 creator A5076647363 @default.
• W1973076433 creator A5088986458 @default.
• W1973076433 date "1990-05-01" @default.
• W1973076433 modified "2023-09-23" @default.
• W1973076433 title "HLA-DP+ T cells and deficient interleukin-2 production in patients with systemic lupus erythematosus" @default.
• W1973076433 cites W1510707687 @default.
• W1973076433 cites W1977067701 @default.
• W1973076433 cites W1979539936 @default.
• W1973076433 cites W1994636482 @default.
• W1973076433 cites W2008649002 @default.
• W1973076433 cites W2010277232 @default.
• W1973076433 cites W2010912681 @default.
• W1973076433 cites W2014180091 @default.
• W1973076433 cites W2039347776 @default.
• W1973076433 cites W2041506169 @default.
• W1973076433 cites W2051197009 @default.
• W1973076433 cites W2070317421 @default.
• W1973076433 cites W2083276447 @default.
• W1973076433 cites W2095905668 @default.
• W1973076433 cites W2103838106 @default.
• W1973076433 cites W2112677765 @default.
• W1973076433 cites W2120979416 @default.
• W1973076433 cites W2121821949 @default.
• W1973076433 cites W2146203649 @default.
• W1973076433 cites W2148231718 @default.
• W1973076433 cites W2150684008 @default.
• W1973076433 cites W2164942430 @default.
• W1973076433 cites W2165271672 @default.
• W1973076433 cites W2289910292 @default.
• W1973076433 cites W93322927 @default.
• W1973076433 doi "https://doi.org/10.1016/0090-1229(90)90104-x" @default.
• W1973076433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2323107" @default.
• W1973076433 hasPublicationYear "1990" @default.
• W1973076433 type Work @default.
• W1973076433 sameAs 1973076433 @default.
• W1973076433 citedByCount "44" @default.
• W1973076433 countsByYear W19730764332013 @default.
• W1973076433 crossrefType "journal-article" @default.
• W1973076433 hasAuthorship W1973076433A5003122942 @default.
• W1973076433 hasAuthorship W1973076433A5018977107 @default.
• W1973076433 hasAuthorship W1973076433A5050835989 @default.
• W1973076433 hasAuthorship W1973076433A5054986463 @default.
• W1973076433 hasAuthorship W1973076433A5061947125 @default.
• W1973076433 hasAuthorship W1973076433A5070334003 @default.
• W1973076433 hasAuthorship W1973076433A5075235588 @default.
• W1973076433 hasAuthorship W1973076433A5075427398 @default.
• W1973076433 hasAuthorship W1973076433A5076647363 @default.
• W1973076433 hasAuthorship W1973076433A5088986458 @default.
• W1973076433 hasConcept C126322002 @default.
• W1973076433 hasConcept C147483822 @default.
• W1973076433 hasConcept C153911025 @default.
• W1973076433 hasConcept C188280979 @default.
• W1973076433 hasConcept C203014093 @default.
• W1973076433 hasConcept C207936829 @default.
• W1973076433 hasConcept C2776090121 @default.
• W1973076433 hasConcept C2776912625 @default.
• W1973076433 hasConcept C2777371288 @default.
• W1973076433 hasConcept C2778690821 @default.
• W1973076433 hasConcept C2778814158 @default.
• W1973076433 hasConcept C2779134260 @default.
• W1973076433 hasConcept C71924100 @default.
• W1973076433 hasConcept C74172505 @default.
• W1973076433 hasConcept C86803240 @default.
• W1973076433 hasConcept C8891405 @default.
• W1973076433 hasConceptScore W1973076433C126322002 @default.
• W1973076433 hasConceptScore W1973076433C147483822 @default.
• W1973076433 hasConceptScore W1973076433C153911025 @default.
• W1973076433 hasConceptScore W1973076433C188280979 @default.
• W1973076433 hasConceptScore W1973076433C203014093 @default.
• W1973076433 hasConceptScore W1973076433C207936829 @default.
• W1973076433 hasConceptScore W1973076433C2776090121 @default.
• W1973076433 hasConceptScore W1973076433C2776912625 @default.
• W1973076433 hasConceptScore W1973076433C2777371288 @default.
• W1973076433 hasConceptScore W1973076433C2778690821 @default.
• W1973076433 hasConceptScore W1973076433C2778814158 @default.
• W1973076433 hasConceptScore W1973076433C2779134260 @default.
• W1973076433 hasConceptScore W1973076433C71924100 @default.
• W1973076433 hasConceptScore W1973076433C74172505 @default.
• W1973076433 hasConceptScore W1973076433C86803240 @default.
• W1973076433 hasConceptScore W1973076433C8891405 @default.
• W1973076433 hasIssue "2" @default.
• W1973076433 hasLocation W19730764331 @default.
• W1973076433 hasLocation W19730764332 @default.
• W1973076433 hasOpenAccess W1973076433 @default.
• W1973076433 hasPrimaryLocation W19730764331 @default.
• W1973076433 hasRelatedWork W2005380527 @default.
• W1973076433 hasRelatedWork W2035319065 @default.
• W1973076433 hasRelatedWork W2060941543 @default.

• next