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- W1973083840 abstract "A total of 23 patients who developed heparin-induced thrombocytopenia following exposure to heparin solely due to intravascular catheter or filter flush were the subjects of prospective studies of argatroban therapy. Heparin doses were 10–13,000 U, with a mean exposure of 8±4 days. Following heparin-induced thrombocytopenia diagnosis and heparin cessation, 13 patients received argatroban (mean dose of 1.8±1.1μg/kg/min for 5.5±3.9 days), achieving activated partial thromboplastin times of 63±23 seconds, and 10 historical control patients received no direct thrombin inhibitors. Platelet count recovered to a mean of 207±153×109/L (n=12) after 5.5±3.9 days of argatroban therapy and to a mean of 127±63×109/L (n=8) 5 days after baseline in the control group. A composite end point of death, amputation, or new thrombosis within 37 days occurred in five (38.5%) argatroban-treated patients and four (40%) controls. Death was the most common untoward outcome (approximately 30% of each group). No argatroban-treated patient and two (20%) control patients experienced new thrombosis. Major bleeding was comparable between groups. Heparin-induced thrombocytopenia can occur following minimal heparin exposure, including heparin flushes; in these patients, argatroban provides effective alternative anticoagulation as compared with historical controls." @default.
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- W1973083840 date "2005-09-01" @default.
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- W1973083840 title "Thrombocytopenia Following Heparin Flush" @default.
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- W1973083840 doi "https://doi.org/10.1111/j.0889-7204.2005.04693.x" @default.
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