Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973089293> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1973089293 endingPage "77" @default.
- W1973089293 startingPage "72" @default.
- W1973089293 abstract "The leaves of Mikania (Asteraceae) species are used in folk medicine as antispasmodic, antiulcerogenic and antirheumatic agents. Phytochemical screening of the crude hydroalcoholic 70% extract (CHE) of Mikania laevigata Shultz Bip. revealed coumarins, terpenes and organic acids. Antiulcerogenic activity of CHE was evaluated, employing different experimental models in rats, to discern the pharmacological mechanism of action. Both the antisecretory and the cytoprotection hypothesis were evaluated. The crude hydroalcoholic extract (1000 mg/kg body wt., vo) decreased the ulcerative lesion index produced by indomethacin, ethanol, stress and reserpine in rats by 85%, 93%, 82% and 50%, respectively. In the pyloric ligation model, a decrease of hydrogenionic concentration (53%) was observed, suggesting that the pharmacological mechanism has a relationship to antisecretory activity. The antisecretory mechanisms of CHE and the coumarin isolated from M. laevigata were confirmed by acid hypersecretion induced by histamine, pentagastrin and bethanechol. Duodenal administration of CHE (1000 mg/kg body wt.) and coumarin (100 mg/kg body wt.) inhibited only the gastric acid secretion produced by bethanecol. These results suggest that both CHE and coumarin may influence the secretion control mediated by the parasympathetic system." @default.
- W1973089293 created "2016-06-24" @default.
- W1973089293 creator A5005500666 @default.
- W1973089293 creator A5014155414 @default.
- W1973089293 creator A5015458137 @default.
- W1973089293 creator A5028096688 @default.
- W1973089293 creator A5047476629 @default.
- W1973089293 creator A5053929320 @default.
- W1973089293 creator A5077936657 @default.
- W1973089293 creator A5079952565 @default.
- W1973089293 date "2005-01-01" @default.
- W1973089293 modified "2023-10-02" @default.
- W1973089293 title "Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip" @default.
- W1973089293 cites W1647673633 @default.
- W1973089293 cites W1973131192 @default.
- W1973089293 cites W1983995358 @default.
- W1973089293 cites W1994545890 @default.
- W1973089293 cites W1999965452 @default.
- W1973089293 cites W2007165465 @default.
- W1973089293 cites W2008487661 @default.
- W1973089293 cites W2018978446 @default.
- W1973089293 cites W2032652903 @default.
- W1973089293 cites W2033224071 @default.
- W1973089293 cites W2040021031 @default.
- W1973089293 cites W2052041328 @default.
- W1973089293 cites W2057256243 @default.
- W1973089293 cites W2057415975 @default.
- W1973089293 cites W2085628805 @default.
- W1973089293 cites W2086309348 @default.
- W1973089293 cites W2087049890 @default.
- W1973089293 cites W2091259735 @default.
- W1973089293 cites W2123022315 @default.
- W1973089293 cites W2160896806 @default.
- W1973089293 cites W4235719707 @default.
- W1973089293 cites W4249424055 @default.
- W1973089293 cites W2016836184 @default.
- W1973089293 doi "https://doi.org/10.1016/j.phymed.2003.09.006" @default.
- W1973089293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15693711" @default.
- W1973089293 hasPublicationYear "2005" @default.
- W1973089293 type Work @default.
- W1973089293 sameAs 1973089293 @default.
- W1973089293 citedByCount "130" @default.
- W1973089293 countsByYear W19730892932012 @default.
- W1973089293 countsByYear W19730892932013 @default.
- W1973089293 countsByYear W19730892932014 @default.
- W1973089293 countsByYear W19730892932015 @default.
- W1973089293 countsByYear W19730892932016 @default.
- W1973089293 countsByYear W19730892932017 @default.
- W1973089293 countsByYear W19730892932018 @default.
- W1973089293 countsByYear W19730892932019 @default.
- W1973089293 countsByYear W19730892932020 @default.
- W1973089293 countsByYear W19730892932022 @default.
- W1973089293 countsByYear W19730892932023 @default.
- W1973089293 crossrefType "journal-article" @default.
- W1973089293 hasAuthorship W1973089293A5005500666 @default.
- W1973089293 hasAuthorship W1973089293A5014155414 @default.
- W1973089293 hasAuthorship W1973089293A5015458137 @default.
- W1973089293 hasAuthorship W1973089293A5028096688 @default.
- W1973089293 hasAuthorship W1973089293A5047476629 @default.
- W1973089293 hasAuthorship W1973089293A5053929320 @default.
- W1973089293 hasAuthorship W1973089293A5077936657 @default.
- W1973089293 hasAuthorship W1973089293A5079952565 @default.
- W1973089293 hasConcept C178790620 @default.
- W1973089293 hasConcept C185592680 @default.
- W1973089293 hasConcept C195475562 @default.
- W1973089293 hasConcept C2776798904 @default.
- W1973089293 hasConcept C2781338262 @default.
- W1973089293 hasConcept C556039675 @default.
- W1973089293 hasConcept C71924100 @default.
- W1973089293 hasConcept C98274493 @default.
- W1973089293 hasConceptScore W1973089293C178790620 @default.
- W1973089293 hasConceptScore W1973089293C185592680 @default.
- W1973089293 hasConceptScore W1973089293C195475562 @default.
- W1973089293 hasConceptScore W1973089293C2776798904 @default.
- W1973089293 hasConceptScore W1973089293C2781338262 @default.
- W1973089293 hasConceptScore W1973089293C556039675 @default.
- W1973089293 hasConceptScore W1973089293C71924100 @default.
- W1973089293 hasConceptScore W1973089293C98274493 @default.
- W1973089293 hasIssue "1-2" @default.
- W1973089293 hasLocation W19730892931 @default.
- W1973089293 hasLocation W19730892932 @default.
- W1973089293 hasOpenAccess W1973089293 @default.
- W1973089293 hasPrimaryLocation W19730892931 @default.
- W1973089293 hasRelatedWork W1968604737 @default.
- W1973089293 hasRelatedWork W2072273640 @default.
- W1973089293 hasRelatedWork W2084267068 @default.
- W1973089293 hasRelatedWork W2228492236 @default.
- W1973089293 hasRelatedWork W2401212985 @default.
- W1973089293 hasRelatedWork W2549128777 @default.
- W1973089293 hasRelatedWork W2949948670 @default.
- W1973089293 hasRelatedWork W2950284420 @default.
- W1973089293 hasRelatedWork W4213279518 @default.
- W1973089293 hasRelatedWork W2509200003 @default.
- W1973089293 hasVolume "12" @default.
- W1973089293 isParatext "false" @default.
- W1973089293 isRetracted "false" @default.
- W1973089293 magId "1973089293" @default.
- W1973089293 workType "article" @default.