FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973095792> ?p ?o ?g. }

• W1973095792 endingPage "413" @default.
• W1973095792 startingPage "403" @default.
• W1973095792 abstract "Cell response to genotoxic agents is complex and involves the participation of different classes of genes (DNA repair, cell cycle control, signal transduction, apoptosis and oncogenesis). In this report, we present three approaches to document gene expression profiles, dealing with the evaluation of cellular responses to genotoxic agents (gamma-rays from 60Cobalt and cyclophosphamide). We used the method of cDNA arrays to analyze the differential gene expression profiles that were displayed by lymphocytes from radiation-exposed individuals, a human fibroblast cell line, and T lymphocytes from systemic lupus erythematosus (SLE) patients who were treated with cyclophosphamide. A preliminary analysis performed in lymphocytes from three radiation-workers showed that several induced genes can be associated with cell response to ionizing radiation: TRRAP (cell cycle regulation), Ligase IV (DNA repair), MAPK8IP1 and MAPK10 (signal transduction), RASSF2 (apoptosis induction/tumorigenesis), p53 (damage response/maintenance of genetic stability). The in vitro irradiated normal VH16 cell line (primary) showed a complex response to the genotoxic stress at the molecular level. Many apoptotic pathways were concomitantly induced. In addition, several genes involved in signaling and cell cycle arrest/control were significantly modulated after irradiation. Many genes involved in oxidative damage were also induced, indicating that this mechanism seems to be an important component of cell response. After treatment of the SLE patients with cyclophosphamide, 154 genes were differentially and significantly induced. Among them, we identified those associated with drug detoxification, cell cycle control, apoptosis, and tumor-suppressor. These findings indicate that at least two apoptotic pathways were induced after cyclophosphamide treatment. The induction of APAF1 and two genes coding for two subunits of cytochrome c supports a previous report showing increased apoptosis in lymphocytes from SLE patients. The present study provides new information on the molecular mechanism underlying the cell response to genotoxic stress, with relevance to basic and clinical research." @default.
• W1973095792 created "2016-06-24" @default.
• W1973095792 creator A5002854120 @default.
• W1973095792 creator A5005316342 @default.
• W1973095792 creator A5014230876 @default.
• W1973095792 creator A5024985291 @default.
• W1973095792 creator A5028687670 @default.
• W1973095792 creator A5050708797 @default.
• W1973095792 creator A5061587246 @default.
• W1973095792 creator A5074529193 @default.
• W1973095792 creator A5086610350 @default.
• W1973095792 date "2003-11-01" @default.
• W1973095792 modified "2023-10-15" @default.
• W1973095792 title "Gene expression profiles in human cells submitted to genotoxic stress" @default.
• W1973095792 cites W1503892898 @default.
• W1973095792 cites W1942214720 @default.
• W1973095792 cites W1945628007 @default.
• W1973095792 cites W1978967080 @default.
• W1973095792 cites W1981356416 @default.
• W1973095792 cites W1992536118 @default.
• W1973095792 cites W1996979039 @default.
• W1973095792 cites W2000757956 @default.
• W1973095792 cites W2008257691 @default.
• W1973095792 cites W2020605362 @default.
• W1973095792 cites W2021318316 @default.
• W1973095792 cites W2029826514 @default.
• W1973095792 cites W2034562270 @default.
• W1973095792 cites W2034872795 @default.
• W1973095792 cites W2049116118 @default.
• W1973095792 cites W2054881197 @default.
• W1973095792 cites W2063308564 @default.
• W1973095792 cites W2068719237 @default.
• W1973095792 cites W2072069835 @default.
• W1973095792 cites W2076835822 @default.
• W1973095792 cites W2081927132 @default.
• W1973095792 cites W2085485064 @default.
• W1973095792 cites W2085862287 @default.
• W1973095792 cites W2086565810 @default.
• W1973095792 cites W2087450028 @default.
• W1973095792 cites W2092279954 @default.
• W1973095792 cites W2095564407 @default.
• W1973095792 cites W2105827711 @default.
• W1973095792 cites W2110620600 @default.
• W1973095792 cites W2113349101 @default.
• W1973095792 cites W2118364944 @default.
• W1973095792 cites W2146203649 @default.
• W1973095792 cites W2150926065 @default.
• W1973095792 cites W2163459725 @default.
• W1973095792 cites W2163946737 @default.
• W1973095792 cites W2165068352 @default.
• W1973095792 cites W2170637645 @default.
• W1973095792 cites W2175131107 @default.
• W1973095792 cites W2313234843 @default.
• W1973095792 cites W2313965592 @default.
• W1973095792 cites W2328184377 @default.
• W1973095792 cites W2403478040 @default.
• W1973095792 cites W4294107304 @default.
• W1973095792 doi "https://doi.org/10.1016/j.mrrev.2003.07.004" @default.
• W1973095792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14644343" @default.
• W1973095792 hasPublicationYear "2003" @default.
• W1973095792 type Work @default.
• W1973095792 sameAs 1973095792 @default.
• W1973095792 citedByCount "54" @default.
• W1973095792 countsByYear W19730957922012 @default.
• W1973095792 countsByYear W19730957922013 @default.
• W1973095792 countsByYear W19730957922014 @default.
• W1973095792 countsByYear W19730957922015 @default.
• W1973095792 countsByYear W19730957922016 @default.
• W1973095792 countsByYear W19730957922018 @default.
• W1973095792 countsByYear W19730957922019 @default.
• W1973095792 countsByYear W19730957922020 @default.
• W1973095792 countsByYear W19730957922022 @default.
• W1973095792 countsByYear W19730957922023 @default.
• W1973095792 crossrefType "journal-article" @default.
• W1973095792 hasAuthorship W1973095792A5002854120 @default.
• W1973095792 hasAuthorship W1973095792A5005316342 @default.
• W1973095792 hasAuthorship W1973095792A5014230876 @default.
• W1973095792 hasAuthorship W1973095792A5024985291 @default.
• W1973095792 hasAuthorship W1973095792A5028687670 @default.
• W1973095792 hasAuthorship W1973095792A5050708797 @default.
• W1973095792 hasAuthorship W1973095792A5061587246 @default.
• W1973095792 hasAuthorship W1973095792A5074529193 @default.
• W1973095792 hasAuthorship W1973095792A5086610350 @default.
• W1973095792 hasConcept C104317684 @default.
• W1973095792 hasConcept C105696609 @default.
• W1973095792 hasConcept C134935766 @default.
• W1973095792 hasConcept C143425029 @default.
• W1973095792 hasConcept C153911025 @default.
• W1973095792 hasConcept C190283241 @default.
• W1973095792 hasConcept C29537977 @default.
• W1973095792 hasConcept C502942594 @default.
• W1973095792 hasConcept C54355233 @default.
• W1973095792 hasConcept C552990157 @default.
• W1973095792 hasConcept C555283112 @default.
• W1973095792 hasConcept C62478195 @default.
• W1973095792 hasConcept C86803240 @default.
• W1973095792 hasConcept C95444343 @default.
• W1973095792 hasConceptScore W1973095792C104317684 @default.

• next