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- W1973097527 startingPage "1089" @default.
- W1973097527 abstract "Loss of skeletal muscle tissue (cachexia) is one of the hallmarks of HIV infection. It has been found (1) that creatine kinase, i.e., an enzyme of pivotal importance in muscular mitochondrial energy metabolism, is inhibited by oxidative glutathiolation, and (2) that reduced glutathione (GSH) is decreased in skeletal muscle of SIV-infected rhesus monkeys. We, therefore, have studied the phosphocreatine (P-Cr) levels. Muscle tissue from SIV-infected macaques showed significantly decreased P-Cr but normal creatine (Cr), ATP, and ADP when compared with uninfected macaques. Individual P-Cr levels were significantly correlated with GSH. Our findings may explain the dysregulation of energy metabolism in cachexia." @default.
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- W1973097527 date "1997-09-01" @default.
- W1973097527 modified "2023-09-24" @default.
- W1973097527 title "Decrease in Phosphocreatine Level in Skeletal Muscle of SIV-Infected Rhesus Macaques Correlates with Decrease in Intracellular Glutathione" @default.
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- W1973097527 doi "https://doi.org/10.1089/aid.1997.13.1089" @default.
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