FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973102191> ?p ?o ?g. }

• W1973102191 endingPage "e25269" @default.
• W1973102191 startingPage "e25269" @default.
• W1973102191 abstract "Nonalcoholic fatty liver disease (NAFLD) is a known outcome of hepatosteatosis. Free fatty acids (FFA) induce the unfolded protein response (UPR) or endoplasmic reticulum (ER) stress that may induce apoptosis. Recent data indicate ER stress to be a major player in the progression of fatty liver to more aggressive lesions. Autophagy on the other hand has been demonstrated to be protective against ER stress-induced cell death. We hypothesized that exendin-4 (GLP-1 analog) treatment of fat loaded hepatocytes can reduce steatosis by autophagy which leads to reduced ER stress-related hepatocyte apoptosis.Primary human hepatocytes were loaded with saturated, cis- and trans-unsaturated fatty acids (palmitic, oleic and elaidic acid respectively). Steatosis, induced with all three fatty acids, was significantly resolved after exendin-4 treatment. Exendin-4 sustained levels of GRP78 expression in fat-loaded cells when compared to untreated fat-loaded cells alone. In contrast, CHOP (C/EBP homologous protein); the penultimate protein that leads to ER stress-related cell death was significantly decreased by exendin-4 in hepatocytes loaded with fatty acids. Finally, exendin-4 in fat loaded hepatocytes clearly promoted gene products associated with macroautophagy as measured by enhanced production of both Beclin-1 and LC3B-II, markers for autophagy; and visualized by transmission electron microscopy (TEM). Similar observations were made in mouse liver lysates after mice were fed with high fat high fructose diet and treated with a long acting GLP-1 receptor agonist, liraglutide.GLP-1 proteins appear to protect hepatocytes from fatty acid-related death by prohibition of a dysfunctional ER stress response; and reduce fatty acid accumulation, by activation of both macro-and chaperone-mediated autophagy. These findings provide a novel role for GLP-1 proteins in halting the progression of more aggressive lesions from underlying steatosis in humans afflicted with NAFLD." @default.
• W1973102191 created "2016-06-24" @default.
• W1973102191 creator A5035375857 @default.
• W1973102191 creator A5059496981 @default.
• W1973102191 creator A5070853337 @default.
• W1973102191 creator A5085828175 @default.
• W1973102191 creator A5088960523 @default.
• W1973102191 date "2011-09-21" @default.
• W1973102191 modified "2023-10-14" @default.
• W1973102191 title "GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy" @default.
• W1973102191 cites W1590553747 @default.
• W1973102191 cites W1594293927 @default.
• W1973102191 cites W1607232966 @default.
• W1973102191 cites W1968002849 @default.
• W1973102191 cites W1971422032 @default.
• W1973102191 cites W1981618301 @default.
• W1973102191 cites W1985139784 @default.
• W1973102191 cites W1999713841 @default.
• W1973102191 cites W2007505836 @default.
• W1973102191 cites W2007938249 @default.
• W1973102191 cites W2020433001 @default.
• W1973102191 cites W2021242983 @default.
• W1973102191 cites W2022106893 @default.
• W1973102191 cites W2025511820 @default.
• W1973102191 cites W2026142403 @default.
• W1973102191 cites W2026348270 @default.
• W1973102191 cites W2034209605 @default.
• W1973102191 cites W2040615010 @default.
• W1973102191 cites W2046306656 @default.
• W1973102191 cites W2047030225 @default.
• W1973102191 cites W2048876290 @default.
• W1973102191 cites W2053295375 @default.
• W1973102191 cites W2061216487 @default.
• W1973102191 cites W2067038570 @default.
• W1973102191 cites W2073956836 @default.
• W1973102191 cites W2074835704 @default.
• W1973102191 cites W2079569342 @default.
• W1973102191 cites W2087580204 @default.
• W1973102191 cites W2093545531 @default.
• W1973102191 cites W2096308078 @default.
• W1973102191 cites W2098202805 @default.
• W1973102191 cites W2098527497 @default.
• W1973102191 cites W2103156933 @default.
• W1973102191 cites W2110676385 @default.
• W1973102191 cites W2115860183 @default.
• W1973102191 cites W2117875646 @default.
• W1973102191 cites W2118338384 @default.
• W1973102191 cites W2128057304 @default.
• W1973102191 cites W2132600402 @default.
• W1973102191 cites W2139425230 @default.
• W1973102191 cites W2143829302 @default.
• W1973102191 cites W2162051951 @default.
• W1973102191 cites W2165991181 @default.
• W1973102191 cites W2167909421 @default.
• W1973102191 cites W2168326939 @default.
• W1973102191 cites W2168415166 @default.
• W1973102191 cites W2168483072 @default.
• W1973102191 cites W2588932223 @default.
• W1973102191 doi "https://doi.org/10.1371/journal.pone.0025269" @default.
• W1973102191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3177901" @default.
• W1973102191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21957486" @default.
• W1973102191 hasPublicationYear "2011" @default.
• W1973102191 type Work @default.
• W1973102191 sameAs 1973102191 @default.
• W1973102191 citedByCount "211" @default.
• W1973102191 countsByYear W19731021912012 @default.
• W1973102191 countsByYear W19731021912013 @default.
• W1973102191 countsByYear W19731021912014 @default.
• W1973102191 countsByYear W19731021912015 @default.
• W1973102191 countsByYear W19731021912016 @default.
• W1973102191 countsByYear W19731021912017 @default.
• W1973102191 countsByYear W19731021912018 @default.
• W1973102191 countsByYear W19731021912019 @default.
• W1973102191 countsByYear W19731021912020 @default.
• W1973102191 countsByYear W19731021912021 @default.
• W1973102191 countsByYear W19731021912022 @default.
• W1973102191 countsByYear W19731021912023 @default.
• W1973102191 crossrefType "journal-article" @default.
• W1973102191 hasAuthorship W1973102191A5035375857 @default.
• W1973102191 hasAuthorship W1973102191A5059496981 @default.
• W1973102191 hasAuthorship W1973102191A5070853337 @default.
• W1973102191 hasAuthorship W1973102191A5085828175 @default.
• W1973102191 hasAuthorship W1973102191A5088960523 @default.
• W1973102191 hasBestOaLocation W19731021911 @default.
• W1973102191 hasConcept C126322002 @default.
• W1973102191 hasConcept C134018914 @default.
• W1973102191 hasConcept C139447449 @default.
• W1973102191 hasConcept C158617107 @default.
• W1973102191 hasConcept C185592680 @default.
• W1973102191 hasConcept C190283241 @default.
• W1973102191 hasConcept C202751555 @default.
• W1973102191 hasConcept C203522944 @default.
• W1973102191 hasConcept C25095133 @default.
• W1973102191 hasConcept C2776175330 @default.
• W1973102191 hasConcept C2776200302 @default.
• W1973102191 hasConcept C2776954865 @default.
• W1973102191 hasConcept C2777391703 @default.
• W1973102191 hasConcept C2778772119 @default.

• next