FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973102424> ?p ?o ?g. }

• W1973102424 endingPage "e22369" @default.
• W1973102424 startingPage "e22369" @default.
• W1973102424 abstract "Laminin α2 (LAMA2)-deficient congenital muscular dystrophy is a severe, early-onset disease caused by abnormal levels of laminin 211 in the basal lamina leading to muscle weakness, transient inflammation, muscle degeneration and impaired mobility. In a Lama2-deficient mouse model for this disease, animal survival is improved by muscle-specific expression of the apoptosis inhibitor Bcl-2, conferred by a MyoD-hBcl-2 transgene. Here we investigated early disease stages in this model to determine initial pathological events and effects of Bcl-2 on their progression. Using quantitative immunohistological and mRNA analyses we show that inflammation occurs very early in Lama2-deficient muscle, some aspects of which are reduced or delayed by the MyoD-hBcl-2 transgene. mRNAs for innate immune response regulators, including multiple Toll-like receptors (TLRs) and the inflammasome component NLRP3, are elevated in diseased muscle compared with age-matched controls expressing Lama2. MyoD-hBcl-2 inhibits induction of TLR4, TLR6, TLR7, TLR8 and TLR9 in Lama2-deficient muscle compared with non-transgenic controls, and leads to reduced infiltration of eosinophils, which are key death effector cells. This congenital disease model provides a new paradigm for investigating cell death mechanisms during early stages of pathogenesis, demonstrating that interactions exist between Bcl-2, a multifunctional regulator of cell survival, and the innate immune response." @default.
• W1973102424 created "2016-06-24" @default.
• W1973102424 creator A5021512427 @default.
• W1973102424 creator A5056116495 @default.
• W1973102424 creator A5087109319 @default.
• W1973102424 creator A5088709751 @default.
• W1973102424 date "2011-08-05" @default.
• W1973102424 modified "2023-10-15" @default.
• W1973102424 title "Bcl-2 Inhibits the Innate Immune Response during Early Pathogenesis of Murine Congenital Muscular Dystrophy" @default.
• W1973102424 cites W1563834930 @default.
• W1973102424 cites W1963827945 @default.
• W1973102424 cites W1967601848 @default.
• W1973102424 cites W1968854849 @default.
• W1973102424 cites W1989148485 @default.
• W1973102424 cites W1995072780 @default.
• W1973102424 cites W1995347969 @default.
• W1973102424 cites W2009435405 @default.
• W1973102424 cites W2009590338 @default.
• W1973102424 cites W2027745468 @default.
• W1973102424 cites W2033437338 @default.
• W1973102424 cites W2036411709 @default.
• W1973102424 cites W2051131650 @default.
• W1973102424 cites W2066012947 @default.
• W1973102424 cites W2072115152 @default.
• W1973102424 cites W2073845146 @default.
• W1973102424 cites W2087116079 @default.
• W1973102424 cites W2095117681 @default.
• W1973102424 cites W2097268907 @default.
• W1973102424 cites W2101732003 @default.
• W1973102424 cites W2104553354 @default.
• W1973102424 cites W2109491705 @default.
• W1973102424 cites W2110793063 @default.
• W1973102424 cites W2112039060 @default.
• W1973102424 cites W2113515804 @default.
• W1973102424 cites W2118252826 @default.
• W1973102424 cites W2139521871 @default.
• W1973102424 cites W2140571619 @default.
• W1973102424 cites W2141801137 @default.
• W1973102424 cites W2146065336 @default.
• W1973102424 cites W2152997804 @default.
• W1973102424 cites W2158484702 @default.
• W1973102424 cites W2159796957 @default.
• W1973102424 cites W3190496831 @default.
• W1973102424 cites W2088383181 @default.
• W1973102424 doi "https://doi.org/10.1371/journal.pone.0022369" @default.
• W1973102424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3151242" @default.
• W1973102424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21850221" @default.
• W1973102424 hasPublicationYear "2011" @default.
• W1973102424 type Work @default.
• W1973102424 sameAs 1973102424 @default.
• W1973102424 citedByCount "14" @default.
• W1973102424 countsByYear W19731024242012 @default.
• W1973102424 countsByYear W19731024242013 @default.
• W1973102424 countsByYear W19731024242014 @default.
• W1973102424 countsByYear W19731024242015 @default.
• W1973102424 countsByYear W19731024242017 @default.
• W1973102424 countsByYear W19731024242018 @default.
• W1973102424 countsByYear W19731024242022 @default.
• W1973102424 crossrefType "journal-article" @default.
• W1973102424 hasAuthorship W1973102424A5021512427 @default.
• W1973102424 hasAuthorship W1973102424A5056116495 @default.
• W1973102424 hasAuthorship W1973102424A5087109319 @default.
• W1973102424 hasAuthorship W1973102424A5088709751 @default.
• W1973102424 hasBestOaLocation W19731024241 @default.
• W1973102424 hasConcept C102230213 @default.
• W1973102424 hasConcept C104317684 @default.
• W1973102424 hasConcept C136449434 @default.
• W1973102424 hasConcept C203014093 @default.
• W1973102424 hasConcept C207200792 @default.
• W1973102424 hasConcept C2776914184 @default.
• W1973102424 hasConcept C2777209026 @default.
• W1973102424 hasConcept C2778106681 @default.
• W1973102424 hasConcept C2779030066 @default.
• W1973102424 hasConcept C2779768179 @default.
• W1973102424 hasConcept C2780942790 @default.
• W1973102424 hasConcept C3763915 @default.
• W1973102424 hasConcept C54355233 @default.
• W1973102424 hasConcept C86803240 @default.
• W1973102424 hasConcept C8891405 @default.
• W1973102424 hasConcept C95444343 @default.
• W1973102424 hasConceptScore W1973102424C102230213 @default.
• W1973102424 hasConceptScore W1973102424C104317684 @default.
• W1973102424 hasConceptScore W1973102424C136449434 @default.
• W1973102424 hasConceptScore W1973102424C203014093 @default.
• W1973102424 hasConceptScore W1973102424C207200792 @default.
• W1973102424 hasConceptScore W1973102424C2776914184 @default.
• W1973102424 hasConceptScore W1973102424C2777209026 @default.
• W1973102424 hasConceptScore W1973102424C2778106681 @default.
• W1973102424 hasConceptScore W1973102424C2779030066 @default.
• W1973102424 hasConceptScore W1973102424C2779768179 @default.
• W1973102424 hasConceptScore W1973102424C2780942790 @default.
• W1973102424 hasConceptScore W1973102424C3763915 @default.
• W1973102424 hasConceptScore W1973102424C54355233 @default.
• W1973102424 hasConceptScore W1973102424C86803240 @default.
• W1973102424 hasConceptScore W1973102424C8891405 @default.
• W1973102424 hasConceptScore W1973102424C95444343 @default.
• W1973102424 hasIssue "8" @default.
• W1973102424 hasLocation W19731024241 @default.

• next