FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973104262> ?p ?o ?g. }

• W1973104262 abstract "Abstract Background Intracranial pediatric germ cell tumors (GCTs) are rare and heterogeneous neoplasms and vary in histological differentiation, prognosis and clinical behavior. Germinoma and mature teratoma are GCTs that have a good prognosis, while other types of GCTs, termed nongerminomatous malignant germ cell tumors (NGMGCTs), are tumors with an intermediate or poor prognosis. The second group of tumors requires more extensive drug and irradiation treatment regimens. The mechanisms underlying the differences in incidence and prognosis of the various GCT subgroups are unclear. Results We identified a distinct mRNA profile correlating with GCT histological differentiation and prognosis, and also present in this study the first miRNA profile of pediatric primary intracranial GCTs. Most of the differentially expressed miRNAs were downregulated in germinomas, but miR-142-5p and miR-146a were upregulated. Genes responsible for self-renewal (such as POU5F1 (OCT4), NANOG and KLF4) and the immune response were abundant in germinomas, while genes associated with neuron differentiation, Wnt/β-catenin pathway, invasiveness and epithelial-mesenchymal transition (including SNAI2 (SLUG) and TWIST2) were abundant in NGMGCTs. Clear transcriptome segregation based on patient survival was observed, with malignant NGMGCTs being closest to embryonic stem cells. Chromosome copy number variations (CNVs) at cytobands 4q13.3-4q28.3 and 9p11.2-9q13 correlated with GCT malignancy and clinical risk. Six genes (BANK1, CXCL9, CXCL11, DDIT4L, ELOVL6 and HERC5) within 4q13.3-4q28.3 were more abundant in germinomas. Conclusions Our results integrate molecular profiles with clinical observations and provide insights into the underlying mechanisms causing GCT malignancy. The genes, pathways and microRNAs identified have the potential to be novel therapeutic targets." @default.
• W1973104262 created "2016-06-24" @default.
• W1973104262 creator A5003842895 @default.
• W1973104262 creator A5011348808 @default.
• W1973104262 creator A5012929513 @default.
• W1973104262 creator A5028615592 @default.
• W1973104262 creator A5047103208 @default.
• W1973104262 creator A5049740282 @default.
• W1973104262 creator A5053848738 @default.
• W1973104262 creator A5066938511 @default.
• W1973104262 date "2010-02-24" @default.
• W1973104262 modified "2023-10-07" @default.
• W1973104262 title "Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations" @default.
• W1973104262 cites W1518394182 @default.
• W1973104262 cites W1527927437 @default.
• W1973104262 cites W1963691340 @default.
• W1973104262 cites W1964895626 @default.
• W1973104262 cites W1966001496 @default.
• W1973104262 cites W1973853249 @default.
• W1973104262 cites W1977376661 @default.
• W1973104262 cites W1977500292 @default.
• W1973104262 cites W1978337436 @default.
• W1973104262 cites W1980548655 @default.
• W1973104262 cites W1984214021 @default.
• W1973104262 cites W1986960957 @default.
• W1973104262 cites W1988163167 @default.
• W1973104262 cites W1993368245 @default.
• W1973104262 cites W1993452649 @default.
• W1973104262 cites W1994915667 @default.
• W1973104262 cites W1999919168 @default.
• W1973104262 cites W2008696865 @default.
• W1973104262 cites W2009230738 @default.
• W1973104262 cites W2009349221 @default.
• W1973104262 cites W2014691022 @default.
• W1973104262 cites W2020314225 @default.
• W1973104262 cites W2021979602 @default.
• W1973104262 cites W2031132185 @default.
• W1973104262 cites W2035967806 @default.
• W1973104262 cites W2038012681 @default.
• W1973104262 cites W2038167014 @default.
• W1973104262 cites W2043536578 @default.
• W1973104262 cites W2047902204 @default.
• W1973104262 cites W2050339753 @default.
• W1973104262 cites W2055898299 @default.
• W1973104262 cites W2062309393 @default.
• W1973104262 cites W2062565707 @default.
• W1973104262 cites W2065566217 @default.
• W1973104262 cites W2073759231 @default.
• W1973104262 cites W2076534093 @default.
• W1973104262 cites W2080001486 @default.
• W1973104262 cites W2080811177 @default.
• W1973104262 cites W2083160633 @default.
• W1973104262 cites W2086691991 @default.
• W1973104262 cites W2097942421 @default.
• W1973104262 cites W2098117487 @default.
• W1973104262 cites W2099689873 @default.
• W1973104262 cites W2102479123 @default.
• W1973104262 cites W2104708641 @default.
• W1973104262 cites W2105061861 @default.
• W1973104262 cites W2112209835 @default.
• W1973104262 cites W2122683221 @default.
• W1973104262 cites W2125987139 @default.
• W1973104262 cites W2142046859 @default.
• W1973104262 cites W2142144785 @default.
• W1973104262 cites W2152396131 @default.
• W1973104262 cites W2154470196 @default.
• W1973104262 cites W2160566798 @default.
• W1973104262 cites W2169085013 @default.
• W1973104262 cites W2170858162 @default.
• W1973104262 cites W2203909836 @default.
• W1973104262 cites W2322168752 @default.
• W1973104262 cites W4376562502 @default.
• W1973104262 cites W59400444 @default.
• W1973104262 doi "https://doi.org/10.1186/1471-2164-11-132" @default.
• W1973104262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2837036" @default.
• W1973104262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20178649" @default.
• W1973104262 hasPublicationYear "2010" @default.
• W1973104262 type Work @default.
• W1973104262 sameAs 1973104262 @default.
• W1973104262 citedByCount "47" @default.
• W1973104262 countsByYear W19731042622012 @default.
• W1973104262 countsByYear W19731042622013 @default.
• W1973104262 countsByYear W19731042622014 @default.
• W1973104262 countsByYear W19731042622015 @default.
• W1973104262 countsByYear W19731042622016 @default.
• W1973104262 countsByYear W19731042622017 @default.
• W1973104262 countsByYear W19731042622019 @default.
• W1973104262 countsByYear W19731042622020 @default.
• W1973104262 countsByYear W19731042622021 @default.
• W1973104262 countsByYear W19731042622022 @default.
• W1973104262 countsByYear W19731042622023 @default.
• W1973104262 crossrefType "journal-article" @default.
• W1973104262 hasAuthorship W1973104262A5003842895 @default.
• W1973104262 hasAuthorship W1973104262A5011348808 @default.
• W1973104262 hasAuthorship W1973104262A5012929513 @default.
• W1973104262 hasAuthorship W1973104262A5028615592 @default.
• W1973104262 hasAuthorship W1973104262A5047103208 @default.
• W1973104262 hasAuthorship W1973104262A5049740282 @default.
• W1973104262 hasAuthorship W1973104262A5053848738 @default.
• W1973104262 hasAuthorship W1973104262A5066938511 @default.

• next