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- W1973105583 endingPage "751" @default.
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- W1973105583 abstract "The outcomes of Leishmania infection are determined by host immune and nutrition status, parasite species, and co-infection with other pathogens. While subclinical infection and self-healing cutaneous leishmaniasis (CL) are common, uncontrolled parasite replication can lead to non-healing local lesions or visceral leishmaniasis (VL). It is known that infection control requires Th1-differentiation cytokines (IL-12, IL-18, and IL-27) and Th1 cell and macrophage activation. However, there is no generalized consensus for the mechanisms of host susceptibility. The recent studies on regulatory T cells and IL-17-producing cells help explain the effector T cell responses that occur independently of the known Th1/Th2 cell signaling pathways. This review focuses on the immunopathogenesis of non-healing American CL and progressive VL. We summarize recent evidence from human and animal studies that reveals the mechanisms of dysregulated, hyper-responses to Leishmania braziliensis, as well as the presence of disease-promoting or the absence of protective responses to Leishmania amazonensis and Leishmania donovani. We highlight immune-mediated parasite growth and immunopathogenesis, with an emphasis on the putative roles of IL-17 and its related cytokines as well as arginase. A better understanding of the quality and regulation of innate immunity and T cell responses triggered by Leishmania will aid in the rational control of pathology and the infection." @default.
- W1973105583 created "2016-06-24" @default.
- W1973105583 creator A5020114169 @default.
- W1973105583 creator A5041281489 @default.
- W1973105583 creator A5052829973 @default.
- W1973105583 date "2012-10-11" @default.
- W1973105583 modified "2023-10-15" @default.
- W1973105583 title "Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis" @default.
- W1973105583 cites W107280473 @default.
- W1973105583 cites W1490035833 @default.
- W1973105583 cites W1507822347 @default.
- W1973105583 cites W1510330021 @default.
- W1973105583 cites W1514702282 @default.
- W1973105583 cites W1516957658 @default.
- W1973105583 cites W1529713172 @default.
- W1973105583 cites W1532982685 @default.
- W1973105583 cites W1566448473 @default.
- W1973105583 cites W1591750117 @default.
- W1973105583 cites W1650469359 @default.
- W1973105583 cites W1674844815 @default.
- W1973105583 cites W1676233161 @default.
- W1973105583 cites W1732889657 @default.
- W1973105583 cites W1903133754 @default.
- W1973105583 cites W1904014435 @default.
- W1973105583 cites W1914449220 @default.
- W1973105583 cites W1934796349 @default.
- W1973105583 cites W1935835083 @default.
- W1973105583 cites W1949307585 @default.
- W1973105583 cites W1963577621 @default.
- W1973105583 cites W1964727961 @default.
- W1973105583 cites W1965148949 @default.
- W1973105583 cites W1965381885 @default.
- W1973105583 cites W1967813751 @default.
- W1973105583 cites W1969015290 @default.
- W1973105583 cites W1970823370 @default.
- W1973105583 cites W1970975509 @default.
- W1973105583 cites W1971413150 @default.
- W1973105583 cites W1973007471 @default.
- W1973105583 cites W1975159342 @default.
- W1973105583 cites W1975614186 @default.
- W1973105583 cites W1980721552 @default.
- W1973105583 cites W1981160000 @default.
- W1973105583 cites W1983306484 @default.
- W1973105583 cites W1984838539 @default.
- W1973105583 cites W1985622878 @default.
- W1973105583 cites W1986686460 @default.
- W1973105583 cites W1988558327 @default.
- W1973105583 cites W1990994388 @default.
- W1973105583 cites W1991858276 @default.
- W1973105583 cites W1992489519 @default.
- W1973105583 cites W1995028301 @default.
- W1973105583 cites W2001549448 @default.
- W1973105583 cites W2002204067 @default.
- W1973105583 cites W2002615323 @default.
- W1973105583 cites W2003948064 @default.
- W1973105583 cites W2004259237 @default.
- W1973105583 cites W2005726912 @default.
- W1973105583 cites W2005736123 @default.
- W1973105583 cites W2008486285 @default.
- W1973105583 cites W2012299697 @default.
- W1973105583 cites W2015347941 @default.
- W1973105583 cites W2016442369 @default.
- W1973105583 cites W2017295836 @default.
- W1973105583 cites W2017451770 @default.
- W1973105583 cites W2017893786 @default.
- W1973105583 cites W2020711392 @default.
- W1973105583 cites W2020730875 @default.
- W1973105583 cites W2021455453 @default.
- W1973105583 cites W2024764902 @default.
- W1973105583 cites W2026286437 @default.
- W1973105583 cites W2028090721 @default.
- W1973105583 cites W2028695616 @default.
- W1973105583 cites W2030076021 @default.
- W1973105583 cites W2031187765 @default.
- W1973105583 cites W2040231972 @default.
- W1973105583 cites W2043486633 @default.
- W1973105583 cites W2043513030 @default.
- W1973105583 cites W2052833785 @default.
- W1973105583 cites W2053654309 @default.
- W1973105583 cites W2054901225 @default.
- W1973105583 cites W2057028848 @default.
- W1973105583 cites W2057811708 @default.
- W1973105583 cites W2058411735 @default.
- W1973105583 cites W2059118242 @default.
- W1973105583 cites W2061791602 @default.
- W1973105583 cites W2065556986 @default.
- W1973105583 cites W2067091770 @default.
- W1973105583 cites W2067648924 @default.
- W1973105583 cites W2067683419 @default.
- W1973105583 cites W2068852897 @default.
- W1973105583 cites W2069183998 @default.
- W1973105583 cites W2069247542 @default.
- W1973105583 cites W2070588564 @default.
- W1973105583 cites W2073518075 @default.
- W1973105583 cites W2074759202 @default.
- W1973105583 cites W2075534053 @default.
- W1973105583 cites W2075974327 @default.
- W1973105583 cites W2078014742 @default.