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- W1973110813 abstract "Many parasitic organisms use antigenic variability to evade specific immune responses of the host. Antigenic diversity and genotypic differences between parasite clones, antigenic variation and phenotypic variation within a single clone are the most prominent mechanisms that have evolved during evolution. Brayton and colleagues have now discovered a potentially highly efficient mechanism of antigenic variation in the rickettsia Anaplasma marginale [Brayton, K.A. et al. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 4130–4135]. Several membrane proteins have been detected on the surface of A. marginale that differ between clones. Pseudogenes of two of these antigenically variable gene families (msp2 and msp3) appear together, and can be recombined into functional expression sites, giving rise to new antigenic variants. This mechanism is operational in two gene families and the number of antigenically different clones increases theoretically with one order of magnitude, provided the recombination of these genes is optimally controlled. TS" @default.
- W1973110813 created "2016-06-24" @default.
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- W1973110813 date "2001-10-01" @default.
- W1973110813 modified "2023-09-25" @default.
- W1973110813 title "Antigenic variation in Anaplasma marginale" @default.
- W1973110813 doi "https://doi.org/10.1016/s1471-4922(01)02133-x" @default.
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