Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973113376> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1973113376 endingPage "83" @default.
- W1973113376 startingPage "71" @default.
- W1973113376 abstract "To further investigate the immunotoxic effects of tri-n-propyltin chloride (TPTC), tri-n-butyltin chloride (TBTC) and triphenyltin chloride (TPhTC) several cytotoxicity tests with a series of trialkyltin chlorides and TPhTC were carried out, using isolated rat thymocytes as target cells. Thymocytes, cultured in a serum-supplemented medium, were exposed to organotin concentrations ranging from 0.01 to 10 microM for periods up to 30 h. Parameters such as cell count, trypan blue exclusion, chromium release, thymidine incorporation and cyclic AMP production were used to evaluate the cytotoxicity of these compounds. The more lipophilic compounds TPTC, TBTC, tri-n-hexyltin chloride (THTC) and TPhTC appeared most cytotoxic, reducing thymidine incorporation at concentrations as low as 0.05-1 microM. Membrane damage as determined by trypan blue exclusion and chromium release occurred at higher levels (1-10 microM). The water soluble homologue trimethyltin chloride (TMTC) was least effective in all test models. When phosphate-buffered saline supplemented with glucose was used as incubation medium, TBTC appeared more cytotoxic to thymocytes. Using this medium in 5-h incubations the cytotoxicity of TBTC to thymus, bone marrow and red blood cells was compared. Bone marrow cells were slightly less sensitive than thymocytes, while red cells were relatively resistant. In conclusion, of the triorganotin compounds especially the lipophilic homologues are cytotoxic in vitro." @default.
- W1973113376 created "2016-06-24" @default.
- W1973113376 creator A5010945654 @default.
- W1973113376 creator A5030014922 @default.
- W1973113376 creator A5051101725 @default.
- W1973113376 creator A5084677467 @default.
- W1973113376 date "1986-04-01" @default.
- W1973113376 modified "2023-10-12" @default.
- W1973113376 title "Triorganotin-induced cytotoxicity to rat thymus, bone marrow and red blood cells as determined by several in vitro assays" @default.
- W1973113376 cites W1483133258 @default.
- W1973113376 cites W1967096717 @default.
- W1973113376 cites W1970166627 @default.
- W1973113376 cites W1992479960 @default.
- W1973113376 cites W2003601456 @default.
- W1973113376 cites W2005824022 @default.
- W1973113376 cites W2008412397 @default.
- W1973113376 cites W2029257194 @default.
- W1973113376 cites W2029700286 @default.
- W1973113376 cites W2040309216 @default.
- W1973113376 cites W2050802724 @default.
- W1973113376 cites W2056423471 @default.
- W1973113376 cites W2060854026 @default.
- W1973113376 cites W2080016061 @default.
- W1973113376 cites W2084046311 @default.
- W1973113376 cites W2084589199 @default.
- W1973113376 cites W2089498644 @default.
- W1973113376 cites W2124412111 @default.
- W1973113376 cites W2403546930 @default.
- W1973113376 cites W2481105393 @default.
- W1973113376 doi "https://doi.org/10.1016/0300-483x(86)90160-5" @default.
- W1973113376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3008380" @default.
- W1973113376 hasPublicationYear "1986" @default.
- W1973113376 type Work @default.
- W1973113376 sameAs 1973113376 @default.
- W1973113376 citedByCount "77" @default.
- W1973113376 countsByYear W19731133762012 @default.
- W1973113376 countsByYear W19731133762013 @default.
- W1973113376 countsByYear W19731133762014 @default.
- W1973113376 countsByYear W19731133762021 @default.
- W1973113376 crossrefType "journal-article" @default.
- W1973113376 hasAuthorship W1973113376A5010945654 @default.
- W1973113376 hasAuthorship W1973113376A5030014922 @default.
- W1973113376 hasAuthorship W1973113376A5051101725 @default.
- W1973113376 hasAuthorship W1973113376A5084677467 @default.
- W1973113376 hasConcept C109316439 @default.
- W1973113376 hasConcept C153911025 @default.
- W1973113376 hasConcept C154317977 @default.
- W1973113376 hasConcept C178790620 @default.
- W1973113376 hasConcept C185592680 @default.
- W1973113376 hasConcept C202751555 @default.
- W1973113376 hasConcept C203014093 @default.
- W1973113376 hasConcept C25642318 @default.
- W1973113376 hasConcept C2777108182 @default.
- W1973113376 hasConcept C2778695967 @default.
- W1973113376 hasConcept C2780007613 @default.
- W1973113376 hasConcept C2780070996 @default.
- W1973113376 hasConcept C2780484033 @default.
- W1973113376 hasConcept C55493867 @default.
- W1973113376 hasConcept C86803240 @default.
- W1973113376 hasConceptScore W1973113376C109316439 @default.
- W1973113376 hasConceptScore W1973113376C153911025 @default.
- W1973113376 hasConceptScore W1973113376C154317977 @default.
- W1973113376 hasConceptScore W1973113376C178790620 @default.
- W1973113376 hasConceptScore W1973113376C185592680 @default.
- W1973113376 hasConceptScore W1973113376C202751555 @default.
- W1973113376 hasConceptScore W1973113376C203014093 @default.
- W1973113376 hasConceptScore W1973113376C25642318 @default.
- W1973113376 hasConceptScore W1973113376C2777108182 @default.
- W1973113376 hasConceptScore W1973113376C2778695967 @default.
- W1973113376 hasConceptScore W1973113376C2780007613 @default.
- W1973113376 hasConceptScore W1973113376C2780070996 @default.
- W1973113376 hasConceptScore W1973113376C2780484033 @default.
- W1973113376 hasConceptScore W1973113376C55493867 @default.
- W1973113376 hasConceptScore W1973113376C86803240 @default.
- W1973113376 hasIssue "1" @default.
- W1973113376 hasLocation W19731133761 @default.
- W1973113376 hasLocation W19731133762 @default.
- W1973113376 hasOpenAccess W1973113376 @default.
- W1973113376 hasPrimaryLocation W19731133761 @default.
- W1973113376 hasRelatedWork W152847948 @default.
- W1973113376 hasRelatedWork W1979947795 @default.
- W1973113376 hasRelatedWork W2004187546 @default.
- W1973113376 hasRelatedWork W2086432674 @default.
- W1973113376 hasRelatedWork W2169266471 @default.
- W1973113376 hasRelatedWork W2335977771 @default.
- W1973113376 hasRelatedWork W2399843749 @default.
- W1973113376 hasRelatedWork W2406793323 @default.
- W1973113376 hasRelatedWork W2613180760 @default.
- W1973113376 hasRelatedWork W39074122 @default.
- W1973113376 hasVolume "39" @default.
- W1973113376 isParatext "false" @default.
- W1973113376 isRetracted "false" @default.
- W1973113376 magId "1973113376" @default.
- W1973113376 workType "article" @default.