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• W1973120803 abstract "There is a need for biomarkers to monitor the development and progression of type 1 DM. We analyzed mRNA expression levels for granzyme B, perforin, fas ligand, TNF-α, IFN-γ, Foxp3, IL-10, TGF-β, IL-4, IL-6, IL-17, Activation-induced cytidine deaminase (AID) and Immunoglobulin G gamma chain (IgG<gamma>) genes in peripheral blood of at-risk, new-onset and long-term type 1 DM , and healthy controls. The majority of the genes were suppressed in long-term type 1 DM compared to controls and new-onset patients. IFN-γ, IL-4 and IL-10 mRNA levels were significantly higher in new-onset compared to at-risk and long-term groups. There was decreased mRNA expression for AID and IgG<gamma> and up-regulation of IFN-γ with age in controls. Data suggest an overall depressed immunity in long-term type 1 DM. Increased gene expression levels for IFN-γ, IL-4 and IL-10 in new-onset patients from at-risk patients might be used as potential markers for progression of the disease." @default.
• W1973120803 created "2016-06-24" @default.
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• W1973120803 date "2011-06-01" @default.
• W1973120803 modified "2023-10-18" @default.
• W1973120803 title "Immune profiling by multiple gene expression analysis in patients at-risk and with type 1 diabetes" @default.
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• W1973120803 doi "https://doi.org/10.1016/j.clim.2011.02.016" @default.
• W1973120803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3096683" @default.
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