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• W1973130007 abstract "1 SK&F 94836 (racemate) was studied in vivo for its cardiovascular properties in cats and dogs. 2 In anaesthetized cats and dogs SK&F 94836 administered intravenously caused increases in left ventricular contractility and decreases in peripheral vascular resistance at similar doses, thus demonstrating the compound to be a mixed acting positive inotropic/vasodilator agent. 3 In conscious instrumented dogs SK&F 94836 was active via the oral as well as intravenous route. 4 The inodilator activity of SK&F 94836 in conscious and anaesthetized animals occurred in association with minimal changes in either blood pressure or heart rate. 5 Detailed studies carried out on anaesthetized cats indicated that SK&F 94836 caused a balanced dilatation of both resistance and capacitance blood vessels. 6 Haemodynamic studies in anaesthetized cats indicated that as a consequence of the inotropic/vasodilator actions, SK&F 94836 caused significant increases in cardiac output and stroke volume. 7 Detailed studies in anaesthetized dogs indicated that significant inodilator activity occurred in the absence of an increase in myocardial oxygen consumption. 8 The duration of action of SK&F 94836 was sustained following both i.v. and oral administration. 9 We conclude that SK&F 94836, as an orally active inotropic/vasodilator agent with a sustained duration in vivo, has potential utility in the treatment of congestive heart failure." @default.
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• W1973130007 date "1988-04-01" @default.
• W1973130007 modified "2023-09-26" @default.
• W1973130007 title "In vivo pharmacological studies with SK&F 94836, a potent inotrope/vasodilator with a sustained duration of action" @default.
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• W1973130007 doi "https://doi.org/10.1111/j.1476-5381.1988.tb11477.x" @default.
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