Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973136051> ?p ?o ?g. }
- W1973136051 endingPage "246" @default.
- W1973136051 startingPage "242" @default.
- W1973136051 abstract "The metabolism of infused 111In-labeled phospholipid liposomes was examined in Watanabe heritable hyperlipidemic (WHHL) rabbits, which lack low density lipoprotein (LDL) receptors, and in normal control rabbits. The half-times (t1/2) for clearance of 111In and excess phospholipid from plasma were 20.8 +/- 0.9 hr and 20.3 +/- 4.6 hr in WHHL and 20.0 +/- 0.8 hr and 19.6 +/- 2.2 hr in the normal rabbits (means +/- SEM; n = 4). By 6 hr postinfusion, the plasma concentration of unesterified cholesterol increased by 2.2 +/- 0.23 mmol/liter in WHHL and 2.1 +/- 0.04 mmol/liter in normal rabbits, presumably reflecting mobilization of tissue stores. Disappearance of excess plasma cholesterol was greater than 90% complete in both groups of rabbits by 70 hr postinfusion. By quantitative gamma camera imaging, hepatic trapping of 111In-labeled liposomes over time was indistinguishable between the two groups. At autopsy, the liver was the major organ of clearance, acquiring 22.0% +/- 1.7% (WHHL) and 16.8% +/- 1.0% (normal of total 111In. Aortic uptake of 111In was less than 0.02%. Thus, mobilization of cholesterol and hepatic uptake of phospholipid liposomes do not require LDL receptors. Because phospholipid infusions produce rapid substantial regression of atherosclerosis in genetically normal animals, our results suggest that phospholipid liposomes or triglyceride phospholipid emulsions (e.g., Intralipid) might reduce atherosclerosis in WHHL rabbits and in humans with familial hypercholesterolemia." @default.
- W1973136051 created "2016-06-24" @default.
- W1973136051 creator A5002555235 @default.
- W1973136051 creator A5002621242 @default.
- W1973136051 creator A5020127308 @default.
- W1973136051 creator A5023474681 @default.
- W1973136051 creator A5041126515 @default.
- W1973136051 creator A5047722061 @default.
- W1973136051 creator A5066427047 @default.
- W1973136051 date "1988-01-01" @default.
- W1973136051 modified "2023-09-26" @default.
- W1973136051 title "Low density lipoprotein receptor-independent hepatic uptake of a synthetic, cholesterol-scavenging lipoprotein: implications for the treatment of receptor-deficient atherosclerosis." @default.
- W1973136051 cites W13209355 @default.
- W1973136051 cites W1506571572 @default.
- W1973136051 cites W1531185348 @default.
- W1973136051 cites W1543923890 @default.
- W1973136051 cites W1550638578 @default.
- W1973136051 cites W1574029385 @default.
- W1973136051 cites W1602877814 @default.
- W1973136051 cites W1758452282 @default.
- W1973136051 cites W1786406665 @default.
- W1973136051 cites W1868696300 @default.
- W1973136051 cites W1920139491 @default.
- W1973136051 cites W1946263363 @default.
- W1973136051 cites W1961714863 @default.
- W1973136051 cites W1969616236 @default.
- W1973136051 cites W1970803093 @default.
- W1973136051 cites W1978800527 @default.
- W1973136051 cites W1981942016 @default.
- W1973136051 cites W1990011488 @default.
- W1973136051 cites W1995077831 @default.
- W1973136051 cites W1999728690 @default.
- W1973136051 cites W2006371550 @default.
- W1973136051 cites W2017885511 @default.
- W1973136051 cites W2024493540 @default.
- W1973136051 cites W20309224 @default.
- W1973136051 cites W2039337881 @default.
- W1973136051 cites W2041151042 @default.
- W1973136051 cites W2051742401 @default.
- W1973136051 cites W2052287240 @default.
- W1973136051 cites W2057444535 @default.
- W1973136051 cites W2058615744 @default.
- W1973136051 cites W2058712569 @default.
- W1973136051 cites W2070872760 @default.
- W1973136051 cites W2080644290 @default.
- W1973136051 cites W2083940098 @default.
- W1973136051 cites W2088843957 @default.
- W1973136051 cites W2098814816 @default.
- W1973136051 cites W2107091056 @default.
- W1973136051 cites W2135503869 @default.
- W1973136051 cites W2148131794 @default.
- W1973136051 cites W2162757044 @default.
- W1973136051 cites W2182628091 @default.
- W1973136051 cites W2265588327 @default.
- W1973136051 cites W2280884056 @default.
- W1973136051 cites W228128504 @default.
- W1973136051 cites W2312998579 @default.
- W1973136051 cites W2330305733 @default.
- W1973136051 cites W2395998266 @default.
- W1973136051 cites W2407833751 @default.
- W1973136051 cites W2409068998 @default.
- W1973136051 cites W2410575631 @default.
- W1973136051 cites W2432074900 @default.
- W1973136051 cites W2474412863 @default.
- W1973136051 doi "https://doi.org/10.1073/pnas.85.1.242" @default.
- W1973136051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/279520" @default.
- W1973136051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3422421" @default.
- W1973136051 hasPublicationYear "1988" @default.
- W1973136051 type Work @default.
- W1973136051 sameAs 1973136051 @default.
- W1973136051 citedByCount "30" @default.
- W1973136051 countsByYear W19731360512012 @default.
- W1973136051 countsByYear W19731360512014 @default.
- W1973136051 countsByYear W19731360512016 @default.
- W1973136051 countsByYear W19731360512018 @default.
- W1973136051 crossrefType "journal-article" @default.
- W1973136051 hasAuthorship W1973136051A5002555235 @default.
- W1973136051 hasAuthorship W1973136051A5002621242 @default.
- W1973136051 hasAuthorship W1973136051A5020127308 @default.
- W1973136051 hasAuthorship W1973136051A5023474681 @default.
- W1973136051 hasAuthorship W1973136051A5041126515 @default.
- W1973136051 hasAuthorship W1973136051A5047722061 @default.
- W1973136051 hasAuthorship W1973136051A5066427047 @default.
- W1973136051 hasBestOaLocation W19731360511 @default.
- W1973136051 hasConcept C126322002 @default.
- W1973136051 hasConcept C134018914 @default.
- W1973136051 hasConcept C170493617 @default.
- W1973136051 hasConcept C185154212 @default.
- W1973136051 hasConcept C185592680 @default.
- W1973136051 hasConcept C2778163477 @default.
- W1973136051 hasConcept C2778913445 @default.
- W1973136051 hasConcept C2778918659 @default.
- W1973136051 hasConcept C2779120738 @default.
- W1973136051 hasConcept C2779133491 @default.
- W1973136051 hasConcept C2780072125 @default.
- W1973136051 hasConcept C41625074 @default.
- W1973136051 hasConcept C43554185 @default.
- W1973136051 hasConcept C55493867 @default.